Results 41 to 50 of about 45,247 (265)

Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System

Biomolecules, 2023
The antiapoptotic protein Bcl-xL is a major regulator of cell death and survival, but many aspects of its functions remain elusive. It is mostly localized in the mitochondrial outer membrane (MOM) owing to its C-terminal hydrophobic α-helix.
Akandé Rouchidane Eyitayo, Axel Boudier-Lemosquet, Stéphane Chaignepain, Muriel Priault, Stéphen Manon   +4 more
doaj   +1 more source

Role of the C-terminal domain of Bax and Bcl-xL in their localization and function in yeast cells [PDF]

, 1999
It has been suggested that the C-terminal domain of Bcl-2 family members may contain a signal anchor sequence that targets these proteins to the mitochondrial outer membrane.
Camougrand, Nadine, Chaudhuri, Bhabatosh, Manon, Stéphen, Priault, Muriel   +3 more
core   +1 more source

Molecular docking study of naturally derived flavonoids with antiapoptotic BCL-2 and BCL-XL proteins toward ovarian cancer treatment

Journal of Pharmacy and Bioallied Sciences, 2020
The naturally derived flavonoids are well known to have anticarcinogenic effects. Flavonoids could be an alternative strategy for ovarian cancer treatment, due to existing platinum-based drugs are reported to develop resistance with low survival rates ...
Mohd Faiz Abd Ghani, Rozana Othman, Noraziah Nordin   +2 more
doaj   +1 more source

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis [PDF]

, 2022
Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca dynamics by controlling IP receptor (IPR) function. Current models propose distinct roles for Bcl-2 vs.
Ando, Hideaki, Andrews, David W., Bultynck, Geert, Economou, Anastassios, Hamada, Kozo, Ivanova, Hristina, Kale, Justin, Karamanou, Spyridoula, Lemmens, Irma, Louros, Nikolaos, Mikoshiba, Katsuhiko, Parys, Jan B., Rosa, Nicolas, Rousseau, Frederic, Rovere, Rita la, Schymkowitz, Joost, Shabardina, Victoria, Tavernier, Jan, Vandermarliere, Elien, Wagner, Larry E., Welkenhuyzen, Kirsten, Yule, David I.   +21 more
core   +3 more sources

Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family [PDF]

, 2010
Rottlerin is a polyphenolic compound derived from Mallotus philipinensis. In the present study, we show that rottlerin decreased tumor size and stimulated apoptosis in an orthotopic model of pancreatic cancer with no effect on normal tissues in vivo ...
Anna S. Gukovskaya, Clark AS, Eguchi Y, Eibl G, Guha S, Guido Eibl, Irina Odinokova, Izumi Ohno, Kresty LA, Mouad Edderkaoui, Moussa Yazbec, Osamu Yokosuka, Ravinder Abrol, Robert D. Damoiseaux, Soltoff SP, Stephen J. Pandol, Tillman DM, Warburg O, Warburg OP, William A. Goddard   +19 more
core   +2 more sources

Bcl-xL Deamidation Is a Critical Switch in the Regulation of the Response to DNA Damage [PDF]

, 2002
The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues.
Cook, Brian L., Deverman, Benjamin E., Fu, Xiaoyun, Heinecke, Jay W., Kulans, Laura A., Langer, Ellen M., Manson, Scott R., Niederhoff, Robert A., Rosová, Ivana, Roth, Kevin A., Weinberg, Justin S., Weintraub, Steven J.   +11 more
core   +1 more source

Control of cellular Bcl-xL levels by deamidation-regulated degradation. [PDF]

PLoS Biology, 2013
The cellular concentration of Bcl-xL is among the most important determinants of treatment response and overall prognosis in a broad range of tumors as well as an important determinant of the cellular response to several forms of tissue injury.
So Hee Dho, Benjamin E Deverman, Carlo Lapid, Scott R Manson, Lu Gan, Jacob J Riehm, Rajeev Aurora, Ki-Sun Kwon, Steven J Weintraub   +8 more
doaj   +1 more source

NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer [PDF]

, 2020
A sophisticated network of BCL-2 family proteins regulates the mitochondria-associated (intrinsic) apoptosis pathway. Antiapoptotic members such as BCL-XL or MCL-1 safeguard the outer mitochondrial membrane and prevent accidental cell death in a ...
Ehrenschwender, Martin, Knoll, Gertrud, Kranenburg, Onno, Raats, Danielle, Riffelsberger, Petra   +4 more
core   +2 more sources

Conformation of BCL-XL upon Membrane Integration [PDF]

Journal of Molecular Biology, 2015
BCL-XL is an anti-apoptotic BCL-2 family protein found both in the cytosol and bound to intracellular membranes. Structural studies of BCL-XL have advanced by deleting its hydrophobic C-terminus and adding detergents to enhance solubility. However, since the C-terminus is essential for function and detergents strongly affect structure and activity, the
Yong Yao, Lynn M. Fujimoto, Nathan Hirshman, Andrey A. Bobkov, Antonella Antignani, Richard J. Youle, Francesca M. Marassi   +6 more
openaire   +3 more sources

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

PLoS ONE, 2010
Increased expression of Bcl-xL in cancer has been shown to confer resistance to a broad range of apoptotic stimuli and to modulate a number of other aspects of cellular physiology, including energy metabolism, cell cycle, autophagy, mitochondrial fission/
Maria Teresa Vento, Valeria Zazzu, Alessia Loffreda, Justin R Cross, Julian Downward, Maria Patrizia Stoppelli, Ingram Iaccarino   +6 more
doaj   +1 more source