Results 41 to 50 of about 95,261 (258)

Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family [PDF]

, 2010
Rottlerin is a polyphenolic compound derived from Mallotus philipinensis. In the present study, we show that rottlerin decreased tumor size and stimulated apoptosis in an orthotopic model of pancreatic cancer with no effect on normal tissues in vivo ...
Anna S. Gukovskaya, Clark AS, Eguchi Y, Eibl G, Guha S, Guido Eibl, Irina Odinokova, Izumi Ohno, Kresty LA, Mouad Edderkaoui, Moussa Yazbec, Osamu Yokosuka, Ravinder Abrol, Robert D. Damoiseaux, Soltoff SP, Stephen J. Pandol, Tillman DM, Warburg O, Warburg OP, William A. Goddard   +19 more
core   +2 more sources

Deamidation of Bcl-XL [PDF]

Molecular Cell, 2002
Bcl-2 proteins are critical regulators of apoptosis following DNA damage. Recent studies have shown that genotoxic stress induces the deamidation of Bcl-X(L), inhibiting its antiapoptotic activities. Remarkably, Rb and p53 are important regulators of this novel modification of Bcl-X(L).
openaire   +1 more source

Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage [PDF]

Cell Death Discovery, 2016
AbstractCisplatin is a widely used chemotherapeutic agent, yet its efficacy is limited by nephrotoxicity. The severity of nephrotoxicity is associated with the extent of kidney cell death. Previously, we found that cisplatin-induced kidney cell death was dependent on Cdk2 activation, and inhibition of Cdk2 protected cells from cisplatin-induced ...
Seng, NS, Megyesi, J, Tarcsafalvi, A, Price, PM   +3 more
openaire   +2 more sources

Molecular docking study of naturally derived flavonoids with antiapoptotic BCL-2 and BCL-XL proteins toward ovarian cancer treatment

Journal of Pharmacy and Bioallied Sciences, 2020
The naturally derived flavonoids are well known to have anticarcinogenic effects. Flavonoids could be an alternative strategy for ovarian cancer treatment, due to existing platinum-based drugs are reported to develop resistance with low survival rates ...
Mohd Faiz Abd Ghani, Rozana Othman, Noraziah Nordin   +2 more
doaj   +1 more source

Bcl-XL: A multifunctional anti-apoptotic protein

Pharmacological Research, 2020
B-cell lymphoma-extra large (Bcl-XL) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. Bcl-XL is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-XL is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects.
Mingxue, Li, Dun, Wang, Jianhua, He, Lixia, Chen, Hua, Li   +4 more
openaire   +2 more sources

Bad expression influences time to androgen escape in prostate cancer [PDF]

, 2007
<b>OBJECTIVE</b>: To assess the role of selected downstream Bcl-2 family members (Bad, Bax, Bcl-2 and Bcl-xL) in the development of androgen-independent prostate cancer (AIPC), as androgen-deprivation therapy is the treatment of choice in ...
Bracarda S, Chi KN, Edwards J, Eisenmann KM, Gleave M, Huggins C, Ichinose M, Kelekar A, Lebedeva I, McDonnell TJ   +9 more
core   +1 more source

Control of cellular Bcl-xL levels by deamidation-regulated degradation. [PDF]

PLoS Biology, 2013
The cellular concentration of Bcl-xL is among the most important determinants of treatment response and overall prognosis in a broad range of tumors as well as an important determinant of the cellular response to several forms of tissue injury.
So Hee Dho, Benjamin E Deverman, Carlo Lapid, Scott R Manson, Lu Gan, Jacob J Riehm, Rajeev Aurora, Ki-Sun Kwon, Steven J Weintraub   +8 more
doaj   +1 more source

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

PLoS ONE, 2010
Increased expression of Bcl-xL in cancer has been shown to confer resistance to a broad range of apoptotic stimuli and to modulate a number of other aspects of cellular physiology, including energy metabolism, cell cycle, autophagy, mitochondrial fission/
Maria Teresa Vento, Valeria Zazzu, Alessia Loffreda, Justin R Cross, Julian Downward, Maria Patrizia Stoppelli, Ingram Iaccarino   +6 more
doaj   +1 more source

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Trans-1,3-diphenyl-2,3-epoxypropan-1-one, a chalcone derivative, induces apoptosis via ROS-mediated down-regulation of Bcl-xL in human leukemia HL-60 cells [PDF]

, 2015
The anticancer effects of trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP), a chalcone derivative, were investigated in human leukemia HL-60 cells. Treatment of HL-60 cells with various concentration of DPEP resulted in a sequence of events characteristic
Ahn, Ginnae, Cho, Kichul, Jeon, You-Jin, Kim, Daekyung, Kim, Kil-Nam, Ko, Eun-Yi, Ko, Ji-Yeon, Lee, Seung-Hong, Moon, Jeong Yong, Roh, Seong Woon, Yoon, Weon-Jong   +10 more
core   +1 more source