Results 41 to 50 of about 59,389 (246)

Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage [PDF]

Cell Death Discovery, 2016
AbstractCisplatin is a widely used chemotherapeutic agent, yet its efficacy is limited by nephrotoxicity. The severity of nephrotoxicity is associated with the extent of kidney cell death. Previously, we found that cisplatin-induced kidney cell death was dependent on Cdk2 activation, and inhibition of Cdk2 protected cells from cisplatin-induced ...
Seng, NS, Megyesi, J, Tarcsafalvi, A, Price, PM   +3 more
openaire   +2 more sources

Molecular docking study of naturally derived flavonoids with antiapoptotic BCL-2 and BCL-XL proteins toward ovarian cancer treatment

Journal of Pharmacy and Bioallied Sciences, 2020
The naturally derived flavonoids are well known to have anticarcinogenic effects. Flavonoids could be an alternative strategy for ovarian cancer treatment, due to existing platinum-based drugs are reported to develop resistance with low survival rates ...
Mohd Faiz Abd Ghani, Rozana Othman, Noraziah Nordin   +2 more
doaj   +1 more source

Bcl-XL: A multifunctional anti-apoptotic protein

Pharmacological Research, 2020
B-cell lymphoma-extra large (Bcl-XL) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. Bcl-XL is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-XL is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects.
Mingxue, Li, Dun, Wang, Jianhua, He, Lixia, Chen, Hua, Li   +4 more
openaire   +2 more sources

Control of cellular Bcl-xL levels by deamidation-regulated degradation. [PDF]

PLoS Biology, 2013
The cellular concentration of Bcl-xL is among the most important determinants of treatment response and overall prognosis in a broad range of tumors as well as an important determinant of the cellular response to several forms of tissue injury.
So Hee Dho, Benjamin E Deverman, Carlo Lapid, Scott R Manson, Lu Gan, Jacob J Riehm, Rajeev Aurora, Ki-Sun Kwon, Steven J Weintraub   +8 more
doaj   +1 more source

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

PLoS ONE, 2010
Increased expression of Bcl-xL in cancer has been shown to confer resistance to a broad range of apoptotic stimuli and to modulate a number of other aspects of cellular physiology, including energy metabolism, cell cycle, autophagy, mitochondrial fission/
Maria Teresa Vento, Valeria Zazzu, Alessia Loffreda, Justin R Cross, Julian Downward, Maria Patrizia Stoppelli, Ingram Iaccarino   +6 more
doaj   +1 more source

Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells

Haematologica, 2023
BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-XL and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCLX L/BCL-2 ...
Yannan Jia, Lina Han, Cassandra L. Ramage, Zhe Wang, Connie C. Weng, Lei Yang, Simona Colla, Helen Ma, Weiguo Zhang, Michael Andreeff, Naval Daver, Nitin Jain, Naveen Pemmaraju, Kapil Bhalla, Satu Mustjoki, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Qi Zhang, Marina Konopleva   +19 more
doaj   +1 more source

The Effects of Thymoquinone on Viability, and Anti-apoptotic Factors (BCL-XL, BCL-2, MCL-1) in Prostate Cancer (PC3) Cells: An In Vitro and Computer-Simulated Environment Study [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Since active plant ingredients can induce apoptosis in many tumors, in this study we evaluate the apoptotic effects of thymoquinone (TQ) on PC3 cells.
Javad Saffari_Chaleshtori, Ehsan Heidari-Sureshjani, Fahimeh Moradi, Esfandiar Heidarian   +3 more
doaj   +1 more source

Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. [PDF]

PLoS ONE, 2013
Migration and invasion of malignant cells are prerequisites for cancer progression and metastasis. The Bcl-2 family of proteins consists of about 25 members and has been extensively studied in the context of apoptosis.
Bruno Christian Koehler, Anna-Lena Scherr, Stephan Lorenz, Toni Urbanik, Nicole Kautz, Christin Elssner, Stefan Welte, Justo Lorenzo Bermejo, Dirk Jäger, Henning Schulze-Bergkamen   +9 more
doaj   +1 more source

BCL-xL-Dependent Light Scattering by Apoptotic Cells [PDF]

Biophysical Journal, 2004
We measured the intensity ratio of wide-to-narrow angle scatter, optical scatter image ratio (OSIR), in single cells during apoptosis and after overexpression of the mitochondria-bound antiapoptotic protein BCL-xL. OSIR is sensitive to particle size/shape for objects with wavelength-scale dimensions, and was used as a morphometric measure of cellular ...
Boustany, Nada N., Tsai, Yien-Che, Pfister, Bryan, Joiner, Wilsaan M., Oyler, George A., Thakor, Nitish V.   +5 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source