Results 71 to 80 of about 45,247 (265)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
BMC Pharmacology and Toxicology, 2022 Background RNA-cleaving deoxyribozymes (DNAzymes) are catalytic deoxyribonucleic acid molecules that have become a promising new class of gene suppressors by binding and cleaving target mRNA.
Zhen Yu +6 more
doaj +1 more source
Expression of antiapoptotic protein Bcl-xL in optogeneticaly stimulated hippocampal glutamatergic neurons [PDF]
, 2017 The anti-apoptotic protein Bcl-xl takes part in processes of neuroplasticity such as synaptogenesis and release of neurotransmitters. In this study dependence of Bcl-xL expression on neuron activity was analyzed by in vivo optogenetic activating of the ...
Дрозд, У. С.
core
The Role of Bcl-xL Protein Research in Veterinary Oncology [PDF]
International Journal of Molecular Sciences, 2020 Due to their significant impact on human and animal health, cancer diseases are an area of considerable concern for both human and veterinary medicine. Research on the cancer pathogenesis in companion animals, such as dogs, allows not only for improving canine cancer treatment, but also for translating the results into human oncology.
Aleksandra Pawlak, Marta Henklewska
openaire +3 more sources
Advanced Therapeutics, EarlyView.Hispidulin disrupts the KITENIN/ErbB4 oncogenic complex and inhibits KITENIN‐mediated AP‐1 activity, cell invasion, and aerobic glycolysis. It also suppresses the production of cancer‐associated metabolites and downregulates transcriptional regulators downstream of the KITENIN complex.
Mücahit Varlı +7 more
wiley +1 more source
BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. [PDF]
PLoS ONE, 2014 Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL represents a promising strategy for cancer treatment.
Longchuan Bai +6 more
doaj +1 more source
An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation [PDF]
, 2004 A transgenic mouse model of T cell lymphoma was used to investigate the transforming events mediated by an oncogenic tyrosine kinase in pretumorigenic CD4−CD8− (DN) thymocytes.
Alexander, Denis R. +2 more
core +1 more source
Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair
Advanced Science, EarlyView.This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng +8 more
wiley +1 more source
PLoS Pathogens, 2023 Kaposi's Sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma (KS), a highly vascularized tumor common in AIDS patients and many countries in Africa.
Lyndsey N Moore +4 more
doaj +1 more source