Results 71 to 80 of about 8,288 (202)

Silver nanoparticles inhibit beige fat function and promote adiposity

Molecular Metabolism, 2019
Objective: Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society.
Lishu Yue, Wenjun Zhao, Dongmei Wang, Meiyao Meng, Ying Zheng, Yu Li, Jin Qiu, Jian Yu, Yang Yan, Peng Lu, Youmin Sun, Jie Fu, Jiqiu Wang, Qiang Zhang, Lingyan Xu, Xinran Ma   +15 more
doaj   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, EarlyView.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Stepping Up Human Beige Fat Cell Production

Cell Reports, 2018
Beige fat cells hold significant promise for reducing obesity and metabolic disease. Su et al. (2018) present a robust method to produce human beige adipocytes from pluripotent stem cells via the generation of an expandable intermediary population of ...
Wenli Yang, Patrick Seale
doaj   +1 more source

Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells

The Journal of Physiology, EarlyView.
Abstract figure legend Knockdown of Septin7 alters the expression of markers responsible for mitochondrial dynamics. Members of the electron transport chain are also affected by diminished Septin7 level resulting in functional changes of mitochondrial respiration. Abstract Mitochondria are dynamic organelles that undergo fusion and fission.
Andrea Telek, Ivett Gabriella Szabó, Anikó Keller‐Pintér, Mónika Gönczi, Eliza Guti, László Szabó, Brigitta Tillmann, Zoltán Márton Kohler, László Juhász, Péter Bai, Szilárd Póliska, Zsuzsanna Gaál, László Csernoch, János Fodor   +13 more
wiley   +1 more source

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway

Cell Reports, 2018
Summary: Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity.
Xing Zhang, Yan Luo, Chunqing Wang, Xiaofeng Ding, Xin Yang, Dandan Wu, Floyd Silva, Zijiang Yang, Qin Zhou, Lu Wang, Xiaoqing Wang, Jianlin Zhou, Nathan Boyd, Michael Spafford, Mark Burge, Xuexian O. Yang, Meilian Liu   +16 more
doaj   +1 more source

Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis

Frontiers in Physiology, 2021
Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes ...
Chul-Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang   +5 more
doaj   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells [PDF]

Diabetes, 2017
Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human beige adipocytes from human induced ...
Guénantin, Anne-Claire, Briand, Nolwenn, Capel, Emilie, Dumont, Florent, Morichon, Romain, Provost, Claire, Stillitano, Francesca, Jeziorowska, Dorota, Siffroi, Jean-Pierre, Hajjar, Roger, Fève, Bruno, Hulot, Jean-Sébastien, Collas, Philippe, Capeau, Jacqueline, Vigouroux, Corinne   +14 more
openaire   +5 more sources

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Journal of Experimental & Clinical Cancer Research, 2019
Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer.
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang   +10 more
doaj   +1 more source