Results 11 to 20 of about 69 (69)
Beige Adipose Tissue Identification and Marker Specificity—Overview [PDF]
Frontiers in Endocrinology, 2021 Adipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the factors that uniquely differentiate beige AT (BeAT) remain to be fully elaborated.
Anna-Claire Pilkington +4 more
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Mirabegron: The most promising adipose tissue beiging agent [PDF]
Physiological Reports, 2021 Accumulation of white adipose tissue (WAT) underlies the obesity epidemic, leading to current therapeutic techniques that are being investigated for their ability to activate/"beige" this tissue. Adipose tissue (AT) beiging has been reported through intermittent cold exposure (CE), exercise, and β3-Adrenergic Receptor (β3AR) agonists.
Neelam Khaper +6 more
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Engineering Human Beige Adipose Tissue
Frontiers in Bioengineering and Biotechnology, 2022 In this study, we described a method for generating functional, beige (thermogenic) adipose microtissues from human microvascular fragments (MVFs). The MVFs were isolated from adipose tissue acquired from adults over 50 years of age. The tissues express thermogenic gene markers and reproduce functions essential for the potential therapeutic impact of ...
Maria A. Gonzalez Porras +7 more
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Peptidoglycan inhibits beigeing of adipose tissue
Acta Pharmaceutica Sinica B, 2022 Abstract Obesity, an epidemic metabolic disease characterized by excessive fat accumulation, causes a significant economic burden on families and the society. The discovery of beige adipocytes has provided us with a brand new approach for the intervention of obesity 1 .
Hong Chen +6 more
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Brown and Beige Adipose Tissue and Aging [PDF]
Frontiers in Endocrinology, 2019 Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes dysfunctional with an increase in production of inflammatory peptides, a decline of those with anti-inflammatory activity and infiltration of macrophages. Adipose organ dysfunction may lead to age-related metabolic alterations.
Zoico, Elena +7 more
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Bioengineering Beige Adipose Tissue Therapeutics [PDF]
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue. Transplantation of brown fat in small animal model systems has confirmed the expectation that brown fat expansion could possibly provide a novel therapeutic to combat obesity and
Kevin M. Tharp, Andreas Stahl
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Hydrogel-based engineering of beige adipose tissue [PDF]
Journal of Materials Chemistry B, 2015 Brown and beige adipose tissues have a significant capacity for energy expenditure that may be exploited as a treatment for obesity and metabolic disease.
Eric M. Brey +8 more
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Brown and Beige Adipose Tissue [PDF]
Endocrinology and Metabolism Clinics of North America, 2016 Overweight and obesity are global health problems placing an ever-increasing demand on health care systems. Brown adipose tissue (BAT) is present in significant amounts in adults. BAT has potential as a fuel for oxidation and dissipation as heat production, which makes it an attractive target for obesity therapy.
John P. Kirwan +3 more
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Matrix-Assisted Transplantation of Functional Beige Adipose Tissue [PDF]
Diabetes, 2015 Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis.
Tharp, Kevin M +8 more
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Maintaining mitochondria in beige adipose tissue [PDF]
Adipocyte, 2019 Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function.
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