Results 21 to 30 of about 69 (69)
MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Objective: Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood.
Milessa Silva Afonso +13 more
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The Gq signalling pathway inhibits brown and beige adipose tissue [PDF]
Nature Communications, 2016 AbstractBrown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the Gq family, and inhibition of
Thorsten Gnad +22 more
openaire +5 more sources
Role of glucocorticoid receptor (GR) in white adipose tissue beiging
Life Sciences, 2023 Glucocorticoids (GCs) play a crucial role in energy homeostasis including white adipose tissue function; however, chronic GC excess is detrimental to mammals' health. White hypertrophic adiposity is a main factor for neuroendocrine-metabolic dysfunctions in monosodium L-glutamate (MSG)-damaged hypercorticosteronemic rat.
Martín, Florencia M. +6 more
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FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue [PDF]
SSRN Electronic Journal, 2021 Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import.
Jinghua Hu +16 more
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Evaluation of markers of beige adipocytes in white adipose tissue of the mouse [PDF]
Nutrition & Metabolism, 2016 There is a growing interest in exploiting the induction of beige or "brite" (brown in white) adipocytes (beigeing) to combat obesity and its comorbidities. However, there is some uncertainty regarding the best markers to evaluate the occurrence or magnitude of beigeing in white adipose tissue in the mouse model.We evaluated the transcript expression of
Kate J. Claycombe +2 more
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Inflammation of brown/beige adipose tissues in obesity and metabolic disease [PDF]
Journal of Internal Medicine, 2018 AbstractMany of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases, are related to the low‐grade chronic inflammation of white adipose tissue. Under white adipocyte stress, local infiltration of immune cells and enhanced production of pro‐inflammatory cytokines together reduce metabolic flexibility and lead to insulin ...
F. Villarroya +4 more
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The role of brown and beige adipose tissue in glycaemic control
Molecular Aspects of Medicine, 2019 For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to ...
Klepac, K. +3 more
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Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton [PDF]
Endocrinology, 2013 Abstract It is known that insulin resistance and type 2 diabetes mellitus are associated with increased fractures and that brown adipose tissue (BAT) counteracts many if not all of the symptoms associated with type 2 diabetes. By the use of FoxC2AD+/Tg mice, a well-established model for induction of BAT, or beige fat, we present data ...
Sima Rahman +5 more
openaire +3 more sources
Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold [PDF]
Scientific Reports, 2019 AbstractIn a recent study, repeated cold application induced beiging in subcutaneous white adipose tissue (SC WAT) of humans independent of body mass index. To identify factors that promote or inhibit beiging, we performed multiplex analysis of gene expression with the Nanostring nCounter system (the probe set contained genes for specific immune cell ...
Brian S. Finlin +9 more
openaire +3 more sources
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations [PDF]
Diabetes, 2015 Regular physical activity and exercise training have long been known to cause adaptations to white adipose tissue (WAT), including decreases in cell size and lipid content and increases in mitochondrial proteins. In this article, we discuss recent studies that have investigated the effects of exercise training on mitochondrial function, the “beiging ...
Kristin I. Stanford +3 more
openaire +3 more sources