Results 31 to 40 of about 69 (69)

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Cell Reports, 2013
The phenomenon of white fat "browning," in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention.
Irina G. Shabalina, Natasa Petrovic, Jasper M.A. de Jong, Anastasia V. Kalinovich, Barbara Cannon, Jan Nedergaard   +5 more
openaire   +4 more sources

Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis? [PDF]

Frontiers in Endocrinology, 2020
Bariatric surgeries induce marked and durable weight loss in individuals with morbid obesity through powerful effects on both food intake and energy expenditure. While alterations in gut-brain communication are increasingly implicated in the improved eating behavior following bariatric surgeries, less is known about the mechanistic basis for energy ...
Mohammed K. Hankir, Florian Seyfried
openaire   +3 more sources

Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue [PDF]

Scientific Reports, 2017
AbstractSustained β3 adrenergic receptor (ADRB3) activation simultaneously upregulates fatty acid synthesis and oxidation in mouse brown, beige, and white adipose tissues; however, the cellular basis of this dual regulation is not known. Treatment of mice with the ADRB3 agonist CL316,243 (CL) increased expression of fatty acid synthase (FASN) and ...
Hyun Jung Kwon, Yun Hee Lee, James G. Granneman, Sang Nam Kim   +3 more
openaire   +3 more sources

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

Molecular Metabolism, 2016
The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals. The helix-loop-helix transcription factor Early B-Cell Factor-2 (EBF2) regulates brown adipose tissue development.
Stine, Rachel R., Shapira, Suzanne N., Lim, Hee-Woong, Ishibashi, Jeff, Harms, Matthew, Won, Kyoung-Jae, Seale, Patrick   +6 more
openaire   +4 more sources

Preadipocyte Uncoupling Protein 1 Expression Invoked by Fibroblast Growth Factors Imprints on Post‐Differentiation White and Brown Adipocyte Phenotype

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Primary preadipocytes from inguinal white or interscapular brown fat were treated with paracrine fibroblast growth factors (FGF) 2, 4, 8, or 9. Treatment induced acute Ucp1 expression in preadipocytes, independent of other browning markers. Upon subsequent differentiation, Ucp1 and browning markers were expressed at levels comparable to untreated cells.
Katharina Kuellmer, Carolin Mönch, Wilma Roch, Christine Wurmser, Patricia S. S. Petersen, Hildigunnur Hermannsdóttir, Mersiha Hasic, Brice Emanuelli, Tobias Fromme   +8 more
wiley   +1 more source

Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging

Cells
Adipose tissue beiging refers to the process by which beige adipocytes emerge in classical white adipose tissue depots. Beige adipocytes dissipate chemical energy and secrete adipokines, such as classical brown adipocytes, to improve systemic metabolism, which is beneficial for people with obesity and metabolic diseases. Cold exposure and β3-adrenergic
Xi Chen, Yifan Wang, Huiqiao Li, Yanru Deng, Charlise Giang, Anying Song, Yu’e Liu, Qiong A. Wang, Yi Zhu   +8 more
openaire   +4 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, Volume 15, Issue 10, Page 1643-1657, October 2025.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Synergistic Effects of Bioactive Compounds on Human Adiposity Mechanisms of Fat Loss and Fat Accumulation

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Chronic diseases are associated with imbalances in adipose tissue, which plays a crucial role in regulating metabolic health. Food‐based bioactive substances (such as polyphenols, terpenoids, peptides, and fibers) impact fat metabolism by influencing the processes of lipolysis, adipogenesis, thermogenesis, and appetite control.
Mohamed Ibrahim Younis, Rawaa H. Tlay, Ammar B. Altemimi, Zheng Ruan, Tarek Gamal Abedelmaksoud   +4 more
wiley   +1 more source

Optical imaging for brown or beige adipose tissue

VIEW
AbstractCurrently, one in three adults worldwide may be obese or overweight. Obesity is characterized by an excess of energy‐storing white fat. An ingenious and sought‐after strategy against obesity is to activate energy‐consuming beige fat, which is converted from white fat or brown fat.
Jiamin Liu, Linjie Ni, Minmin Peng, Yiying Liang, Chan Lu, Hanying Zheng, Zicheng Huang, Jinde Zhang, Ronghe Chen   +8 more
openaire   +2 more sources

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source