Results 41 to 50 of about 38,627 (272)

Crystal structure of 4-methyl-N-{[1-(4-methylbenzoyl)piperidin-4-yl]methyl}benzamide

Acta Crystallographica Section E, 2014
In the title compound, C22H27N2O2, the piperidine ring adopts a half-chair conformation with the benzene rings inclined in a trans orientation with respect to the piperidine ring [dihedral angle between the benzene rings = 89.1 (1)°].
K. Prathebha, D. Reuben Jonathan, S. Sathya, R. Vasanthi, G. Usha   +4 more
doaj   +1 more source

Discovery of Indole-Containing Benzamide Derivatives as HDAC1 Inhibitors with In Vitro and In Vivo Antitumor Activities

Pharmaceutical Fronts, 2022
Targeting histone deacetylases (HDACs) has become an important focus in cancer inhibition. The pharmacophore of HDAC inhibitors (HDACis) reported so far is composed of three parts: a zinc-binding group (ZBG), a hydrophobic cavity-binding linker, and a ...
Xiu Gu, Xin-Yan Peng, Hao Zhang, Bo Han, Min-Ru Jiao, Qiu-Shi Chen, Qing-Wei Zhang   +6 more
doaj   +1 more source

Catch and release’ cascades: a resin-mediated three-component cascade approach to small molecules [PDF]

, 2006
The application of a ‘catch and release’ approach to palladium-catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent ...
Andrew Cook, Bannwarth, Baxter, Brain, Brown, De Luca, Dondas, Gai, Graybill, Grigg, Hoekstra, Kumpathy, Laganis, Larsen, Lee, Ley, Mason, Porcheddu, Ronald Grigg, Sui, Sumiyoshi, Thompson, Thompson, Wu   +23 more
core   +1 more source

N-Benzo[c][1,2,5]thiazol-4-yl-3-trifluoromethylbenzamide

Molbank, 2019
The title compound, N-benzo[c][1,2,5]thiazol-4-yl-3-trifluoromethylbenzamide (1) was synthesized by reacting 3-trifluoromethylbenzoyl chloride (4) and 4-aminobenzo[c][1,2,5]thiadiazole (5). The compound was characterized by various spectroscopic methods (
Hamad H. Al Mamari, Nasser Al Awaimri, Yousuf Al Lawati   +2 more
doaj   +1 more source

One molecule, three crystal structures: conformational trimorphism of N-[(1S)-1-phenylethyl]benzamide

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C15H15NO, is an enantiopure small molecule, which has been synthesized many times, although its crystal structure was never determined. By recrystallization from a variety of solvent mixtures (pure acetonitrile, ethanol–water, toluene–
Fermin Flores Manuel, Martha Sosa Rivadeneyra, Sylvain Bernès   +2 more
doaj   +1 more source

The assessment of acute toxicity of 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide [PDF]

Вестник Витебского государственного медицинского университета, 2022
Objectives. To evaluate the acute toxicity of a benzamide derivative – 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide after a single intragastric administration to laboratory mice and rats.
O.G. Sechko, V.M. Tsarenkov
doaj   +1 more source

Pre-Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations. [PDF]

Angew Chem Int Ed Engl
The kinetics of mechanochemical reactions can be markedly altered through the selective pre‐activation of starting reagents, as revealed through reaction monitoring using time‐resolved in situ powder X‐ray diffraction and ab initio density functional theory simulation.
Heinekamp C, Palmer TM, Al-Sabbagh D, May A, Prinz C, Michalik S, Michalchuk AAL, Emmerling F.   +7 more
europepmc   +2 more sources

A structural systematic study of four isomers of difluoro-N-(3-pyridyl)benzamide [PDF]

, 2009
The four isomers 2,4-, (I), 2,5-, (II), 3,4-, (III), and 3,5-difluoro-N-(3-pyridyl)benzamide, (IV), all with formula C12H8F2N2O, display molecular similarity, with interplanar angles between the C6/C5N rings ranging from 2.94 (11)° in (IV) to 4.48 (18 ...
Anderson, Frankie P., Gallagher, John F., Lough, Alan J., McMahon, Joyce   +3 more
core   +1 more source

N-(2,3-Dimethylphenyl)benzamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
The conformation of the N-H bond in the structure of the title compound, C(15)H(15)NO, is anti to the ortho and meta-methyl substituents in the aniline benzene ring, in contrast to the syn conformation observed with respect to the ortho and meta-chloro substituents in N-(2,3-dichloro-phen-yl)benzamide.
Hartmut Fuess, B. P. Sowmya, Jozef Kožíšek, Miroslav Tokarčík, B. Thimme Gowda   +4 more
openaire   +3 more sources

Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation

Angewandte Chemie, EarlyView.
From redox numbers to red light: Donor oxidation and core reduction potentials predict E0‐0 in cyanoarene dyes, guiding selection of an efficient red‐light catalyst, 4MeODPATPN (PC13). Under 620 nm light, PC13 facilitates Ni‐catalyzed C─heteroatom cross‐couplings (C─N, C─O, C─S) with high functional‐group tolerance and reduced hydrodehalogenation ...
Amir Gizatullin, Tingting Yuan, Sascha Grotjahn, Luigi Cavallo, Burkhard König, Chen Zhu, Magnus Rueping   +6 more
wiley   +2 more sources