Results 21 to 30 of about 2,089 (211)

Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In continuation of our previous studies to optimise potent carbonic anhydrase inhibitors, two new series of isatin N-phenylacetamide based sulphonamides were synthesised and screened for their human (h) carbonic anhydrase (EC 4.2.1.1) inhibitory ...
Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran, Nada M. Mohamed   +4 more
doaj   +1 more source

Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation

International Journal of Biological Macromolecules, 2023
Amyloid fibrils are protein aggregates formed by protein assembly through cross β structures. Inhibition of amyloid fibril formation may contribute to therapy against amyloid-related disorders like Parkinson's, Alzheimer's, and type 2 diabetes. Here we report that several fluorinated sulfonamide compounds, previously shown to inhibit human carbonic ...
Hadi Ali Janvand, Saeid, Ladefoged, Lucy Kate, Zubrienė, Asta, Sakalauskas, Andrius, Christiansen, Gunna, Dudutienė, Virginija, Schiøtt, Birgit, Matulis, Daumantas, Smirnovas, Vytautas, Otzen, Daniel E.   +9 more
openaire   +2 more sources

Bar Adsorptive Microextraction Coated with Carbon-Based Phase Mixtures for Performance-Enhancement to Monitor Selected Benzotriazoles, Benzothiazoles, and Benzenesulfonamides in Environmental Water Matrices

Molecules, 2020
In the present work we propose, for the first time, bar adsorptive microextraction coated with carbon-based phase mixtures, followed by microliquid desorption and high performance liquid chromatography-diode array detection (BAμE-μLD/HPLC-DAD) analysis ...
Samir M. Ahmad, Bruno B.C. Calado, Mariana N. Oliveira, Nuno R. Neng, J.M.F. Nogueira   +4 more
doaj   +1 more source

Synthesis and Antimicrobial Evaluation of Novel Hydrazones and 1,3,4-Oxadiazoles Incorporating Bumetanide Derivatives [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2018
The aim of this study is to synthesize new benzenesulfonamide derivatives that possess antibacterial activity using Bumetanide as a precursor of benzenesulfonamide.
Mahmoud Bendary, Ahmed Abdulrahmanf, Ibrahim Salem, Tarek Ibrahim, Osama El-Sabbag, Samia Mostafa   +5 more
doaj   +1 more source

New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors

Molecules, 2023
This paper reports an investigation into the impact of pyridyl functional groups in conjunction with hydroxide-substituted benzenesulfonamides on the inhibition of human carbonic anhydrase (CA; EC 4.2.1.1) enzymes. These compounds were tested in vitro of
Jacob Combs, Murat Bozdag, Lochlin D. Cravey, Anusha Kota, Robert McKenna, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran   +7 more
doaj   +1 more source

N-Leucinyl benzenesulfonamides as structurally simplified leucyl-tRNA synthetase inhibitors [PDF]

, 2018
N-Leucinyl benzenesulfonamides have been discovered as a novel class of potent inhibitors of E. coli leucyl-tRNA synthetase. The binding of inhibitors to the enzyme was measured by using isothermal titration calorimetry.
Kristaps Jaudzems, Jaudzems, Kristaps, Goessens, W, Gupta, A, Madre, M, Finn, PW, Michael H. Charlton, Kime, Louise, Wil Goessens, Jirgensons, A, Daina Gustina, Paul W. Finn, Madre, Marina, Lola, D, Einars Loza, Kaula, I, Aleksis, R, Randall, CP, Daina Lola, Loza, E, O'Neill, Alex J., Gustina, D, Edmund, Grace, Aigars Jirgensons, Jaudzems, K, Saint-Leger, Adelaide, Lluís Ribas de Pouplana, de Pouplana, LR, Ribas, Lluis, Gustina, Daina, Adélaïde Saint-Leger, Aleksis, Rihards, Louise Kime, Kaula, Ilze, Edmund, G, Goessens, Wil, Kime, L, Arya Gupta, Lola, Daina, Christopher P. Randall, Ilze Kaula, Ribas de Pouplana, L, Grace Edmund, O'Neill, AJ, Charlton, Michael H., Rihards Aleksis, Alex J. O’Neill, Saint-Leger, A, Gupta, Arya, Jirgensons, Aigars, Randall, Christopher P., Charlton, MH, Marina Madre, Loza, Einars, Finn, Paul W.   +54 more
core   +1 more source

Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

Molecules, 2021
A series of benzenesulfonamides incorporating pyrazole- and pyridazinecarboxamides decorated with several bulky moieties has been obtained by original procedures.
Andrea Angeli, Victor Kartsev, Anthi Petrou, Mariana Pinteala, Volodymyr Brovarets, Roman Vydzhak, Svitlana Panchishin, Athina Geronikaki, Claudiu T. Supuran   +8 more
doaj   +1 more source

Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of 16 novel benzenesulfonamides incorporating 1,3,5-triazine moieties substituted with aromatic amines, dimethylamine, morpholine and piperidine were investigated.
Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T. Supuran   +5 more
doaj   +1 more source

Crystal structure of N-(1-allyl-3-chloro-1H-indazol-5-yl)-4-methylbenzenesulfonamide

Acta Crystallographica Section E, 2014
The 3-chloro-1H-indazole system in the title molecule, C17H16ClN3O2S, is almost planar, with the largest deviation from the mean plane being 0.029 (2) Å for one of the N atoms. This system is nearly perpendicular to the allyl chain, as indicated by the C—
Hakima Chicha, El Mostapha Rakib, Mohamed Chigr, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfonamide ...
Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T. Supuran   +7 more
doaj   +1 more source