Results 41 to 50 of about 2,089 (211)

Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone‐based benzenesulfonamides

, 2021
New imidazolinone-based benzenesulfonamides 3a-e and 4a-e were synthesized in three steps and their chemical structures were confirmed by H-1 NMR (nuclear magnetic resonance), C-13 NMR, and high-resolution mass spectrometry.
Halise Inci Gul, Yeliz Demir, Demir, Yeliz, Mehtap Tugrak, TUĞRAK, Mehtap, LEVENT, SERKAN, GÜL, Halise İnci, GÜLÇİN, İlhami, Serkan Levent, Ilhami Gulcin   +9 more
core   +1 more source

Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides [PDF]

, 2014
A series of 4-(substituted)-N-(guanidinyl)benzenesulfonamides bearing biologically active pyrazole, pyrimidine and pyridine moieties were prepared and evaluated for their anticancer activity against human tumor breast cell line (MCF7). These sulfonamides
Marwa El-Gazzar, Mostafa Ghorab, Mansour Alsaid   +2 more
core   +2 more sources

2,5-Dichloro-N-(3-methylphenyl)benzenesulfonamide

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C13H11Cl2NO2S, the dihedral angle between the aromatic rings is 76.62 (10)° and the C—S—N—C linkage between the rings adopts agaucheconformation [torsion angle = −51.4 (2)°]. A weak intramolecular C—H...O interaction closes anS(6) ring.
Shumaila Younas Mughal, Islam Ullah Khan, William T. A. Harrison, Muneeb Hayat Khan, Muhammad Nadeem Arshad   +4 more
openaire   +3 more sources

CSAKD: Determining Absolute Ligand Affinities From 19F NMR Chemical Shift Anisotropy

Angewandte Chemie International Edition, EarlyView.
Affinity determination is crucial in drug discovery, yet remains difficult for weakly binding fragments. We introduce chemical shift anisotropy KD$K_{\text{D}}$ (CSAKD) by 19F$^{19}{\rm F}$ NMR relaxation experiments, a titration‐free method that requires no isotopic labeling.
Simon H. Rüdisser, Gabriela Stadler, Alvar D. Gossert   +2 more
wiley   +1 more source

N-(4-Hydroxyphenyl)benzenesulfonamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The title compound, C(12)H(11)NO(3)S, synthesized by the reaction of benzene sulfonyl chloride with para-amino-phenol, is of inter-est as a precursor to biologically active sulfur-containing heterocyclic compounds. The structure is stabilized by N-H⋯O and O-H⋯O hydrogen bonds.
Islam Ullah Khan, Irfana Mariam, Muhammad Zia‐ur‐Rehman, M. Arif Sajjad, Shahzad Sharif   +4 more
openaire   +2 more sources

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source

Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2016
A series of sulfonamide derivatives (2a-l) incorporating substituted pyridazinone moieties were investigated for the inhibition of two human cytosolic carbonic anhydrase isoforms, hCA I and hCA II. All these compounds, together with the clinically used sulfonamide acetazolamide were investigated as inhibitors of the physiologically relevant isozymes I ...
Yaseen, Raed, Ekinci, Deniz, Senturk, Murat, Hameed, Alhamzah D.h., Ovais, Syed, Rathore, Pooja, Samim, Mohammed, Javed, Kalim, SUPURAN, CLAUDIU TRANDAFIR   +8 more
openaire   +6 more sources

4-Bromo-N-(4-bromophenyl)benzenesulfonamide [PDF]

IUCrData, 2016
The molecule of the title compound, C12H9Br2NO2S, is U shaped with the central C—S—N—C segment having a torsion angle of 63.2 (4)°. Further, the dihedral angle between the benzene rings is 38.5 (2)°. The crystal structure features strong N—H...O hydrogen bonds that form infinite [100]C(4) chains.
Vinola Z. Rodrigues, S. Naveen, N. K. Lokanath, P. A. Suchetan   +3 more
openaire   +2 more sources

Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.

, 2007
A novel series of benzenesulfonamides that contain ferrocenyl or ruthenocenyl moieties were synthesized and investigated for their ability to inhibit the enzymatic activity of physiologically relevant carbonic anhydrase (CA) isozymes: hCA I, II and ...
Innocenti, Alessio, Vullo, Daniela, T. Supuran, Claudiu, Salmon, Adam, Williams, Michael, Vullo, Damela, Williams, Michael L, Supuran, Claudiu T, Poulsen, Sally-Ann, Salmon, Adam J   +9 more
core   +1 more source

The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II

Biomolecules, 2020
The fluorination of lead-like compounds is a common tool in medicinal chemistry to alter molecular properties in various ways and with different goals. We herein present a detailed study of the binding of fluorinated benzenesulfonamides to human Carbonic
Steffen Glöckner, Khang Ngo, Björn Wagner, Andreas Heine, Gerhard Klebe   +4 more
doaj   +1 more source