Results 31 to 40 of about 2,089 (211)

Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ).
Rosaria Gitto, Laura De Luca, Francesca Mancuso, Sonia Del Prete, Daniela Vullo, Claudiu T. Supuran, Clemente Capasso   +6 more
doaj   +1 more source

Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX

Scientific Reports, 2022
Limited presence of hCA IX in normal physiological tissues and their overexpression only in solid hypoxic tumors made this isoform excellent possible target for developing new anticancer agents.
Abdelrahman I. Zain-Alabdeen, Tarek F. El-Moselhy, Nabaweya Sharafeldin, Andrea Angeli, Claudiu T. Supuran, Mervat H. El-Hamamsy   +5 more
doaj   +1 more source

A Remarkable Accelerating Effect of Ag-Salt on Intramolecular Cyclization of o-(1-Alkynyl)benzenesulfonamides^†

, 2016
Herein, we report transition metal-catalyzed intramolecular cyclization of o-(1-alkynyl)benzenesulfonamides to afford 3-substituted benzothiazines regioselectively via a C−N bond forming reaction and Cu-catalyzed sequential C−N and C−C bond formation ...
N. Kumara Swamy (2471125), Deepak Kumar Barange (2078509), T. C. Nishad (2471122), Venkanna Bandameedi (2471119), K. Vyas (537067), Bukkapattanam R. Sreekanth (2471116), Dinesh Kumar (81794), Manojit Pal (539116)   +7 more
core   +3 more sources

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Human carbonic anhydrase inhibitors (hCAIs) are a key therapeutic class with a multitude of novel applications such as anticonvulsants, topically acting antiglaucoma, and anticancer drugs.
Hossam Nada, Ahmed Elkamhawy, Magda H. Abdellattif, Andrea Angeli, Chang Hoon Lee, Claudiu T. Supuran, Kyeong Lee   +6 more
doaj   +1 more source

Benzenesulfonamide Analogs: Synthesis, Anti-GBM Activity and Pharmacoprofiling. [PDF]

Int J Mol Sci, 2023
The tropomyosin receptor kinase A (TrkA) family of receptor tyrosine kinases (RTKs) emerge as a potential target for glioblastoma (GBM) treatment. Benzenesulfonamide analogs were identified as kinase inhibitors possessing promising anticancer properties.
Murugesan A, Konda Mani S, Thiyagarajan R, Palanivel S, Gurbanov AV, Zubkov FI, Kandhavelu M.   +6 more
europepmc   +5 more sources

2-(Hydrazinocarbonyl)benzenesulfonamide

Acta Crystallographica Section E Structure Reports Online, 2007
In the title compound, C7H9N3O3S, the chiral conformation of the mol­ecule is determined by an intra­molecular N—H⋯O hydrogen bond between the sulfonamide and hydrazino­carbonyl groups, with the former group acting as a donor in hydrogen bonding. The crystal structure is stabilized by inter­molecular N—H⋯O and N—H⋯N hydrogen bonds and π–π stacking ...
Shu-Yan Wang, Wan-Cheng Guo, Ning Ma
openaire   +1 more source

Synthesis and antidiabetic evaluation of benzenesulfonamide derivatives.

Iranian journal of pharmaceutical research : IJPR, 2013
The complex metabolic syndrome, diabetes mellitus, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus.
Hosseinzadeh, Nouraddin, Seraj, Soodeh, Bakhshi-Dezffoli, Mohamad Ebrahim, Hasani, Mohammad, Khoshneviszadeh, Mehdi, Fallah-Bonekohal, Saeed, Abdollahi, Mohammad, Foroumadi, Alireza, Shafiee, Abbas   +8 more
openaire   +2 more sources

Di-<i>meta</i>-Substituted Fluorinated Benzenesulfonamides as Potent and Selective Anticancer Inhibitors of Carbonic Anhydrase IX and XII. [PDF]

J Med Chem
The development of selective drug candidate molecules for cancer-related carbonic anhydrase isozymes IX and XII is challenging due to high homology binding sites among 12 catalytically active isozymes.
Vaškevičius A, Žvirblis M, Kurtenoka M, Leitans J, Manakova E, Paketurytė-Latvė V, Kvietkauskaitė A, Kazaks A, Eimonta V, Čerepenkaitė K, Kazokaitė-Adomaitienė J, Mickevičiu̅tė A, Juozapaitienė V, Tars K, Gražulis S, Matulienė J, Dudutienė V, Shubin K, Matulis D, Zubrienė A.   +19 more
europepmc   +2 more sources

Crystal structure of N-(3-chloro-1-methyl-1H-indazol-5-yl)-4-methoxybenzenesulfonamide

Acta Crystallographica Section E, 2014
In the title compound, C15H14ClN3O3S, the dihedral angle between the planes of the indazole ring system (r.m.s. deviation = 0.007 Å) and the benzene ring is 89.05 (7)°. The methoxy C atom deviates from its attached ring by 0.196 (3) Å.
Hakima Chicha, El Mostapha Rakib, Ahmed Gamouh, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Discovery of Pyrazoline Benzenesulfonamide Derivatives as Anticancer Agents: A Review. [PDF]

Drug Des Devel Ther
Pyrazoline benzenesulfonamide derivatives represent a distinctive class of heterocyclic compounds that synergistically combine the pharmacological versatility of the pyrazoline scaffold with the enzyme-inhibitory prowess of benzenesulfonamide moieties. These hybrids have emerged as promising candidates in anticancer drug discovery.
Hasyim DM, Musfiroh I, Hendra R, Kamarulzaman EE, Ritmaleni R, Muchtaridi M.   +5 more
europepmc   +4 more sources