Results 71 to 80 of about 2,089 (211)

Synthesis, characterization, preliminary molecular docking, pharmacological activity, and ADME studies of some new pyrazoline derivatives as anti-breast cancer agents [PDF]

Pharmacia
This work studied the anti-breast cancer activities of pyrazoline-containing benzenesulfonamides (6–10) in vitro and silico. The GOLD suite performed molecular docking on the target human estrogen receptor and the PARPA1 antagonist crystal structure ...
Hayder R. Fadhil, Ayad M. R. Raauf, Monther F. Mahdi   +2 more
doaj   +3 more sources

Synthesis, Cytotoxicity, and ADME Studies of New Compounds Containing Coumarin–Indazole–Triazole Nucleus

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
In this work, the preparation of new coumarin–indazole–triazole–sulfonamide hybrids via a multistep route has been fine‐tuned. The synthesis involves nitration, reduction, formation of a sulfonamide, alkylation, and CuAAC coupling. The synthesized compounds were screened for antiproliferative activity against MDA‐MB‐231 triple‐negative breast cancer ...
Achraf Hibot, Mümin Alper Erdoğan, Abderrafia Hafid, Mostafa Khouili, Güliz Armagan, Maria Dolors Pujol   +5 more
wiley   +1 more source

4-Bromo-N-(4-fluorophenyl)benzenesulfonamide [PDF]

IUCrData, 2016
The title molecule, C12H9BrFNO2S, is U-shaped with the central C—S—N—C fragment having a torsion angle of 68.4 (3)° and a dihedral angle between the planes of the two benzene rings of 41.17 (19)°. The crystal structure features strong N—H...O hydrogen bonds between the molecules, forming infinite one-dimensionalC(4) chains along [001]. These chains are
Vinola Z. Rodrigues, P. A. Suchetan, L. Saritha, N. K. Lokanath, S. Naveen   +4 more
openaire   +2 more sources

Synthesis and anti-retroviral activity of novel 1,2-benzisothiazol-3(2H)-one benzenesulfonamides targeting the HIV nucleocapsid protein 7 [PDF]

, 2012
The biological activity of new 1,2-benzisothiazol-3(2H)-one benzenesulfonamides is described. In cell-based assays the lead compound 6 inhibits multiplication, but not entry into target cells, of HIV-1, HIV-2 and HIV-1 variants carrying clinically ...
Ouhtit, Aicha
core  

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
We report the synthesis and characterisation of a novel series of triazole benzenesulfonamide derivatives, which incorporate the general pharmacophore associated with carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.
Marwa G. El-Gazzar, Nessma H. Nafie, Alessio Nocentini, Mostafa M. Ghorab, Helmi I. Heiba, Claudiu T. Supuran   +5 more
doaj   +1 more source

Tetrazine Functionalized Graphene Enables Capture of Ultra‐Low Concentrations of Biomacromolecules

Small, Volume 22, Issue 28, 18 May 2026.
A novel method for covalent modification of monolayer graphene utilizing tetrazine containing diazonium salt is demonstrated. The modified graphene bearing tetrazine moieties undergoes inverse electron demand Diels‐Alder reactions with trans‐cyclooctene‐linked molecules, enabling bioorthogonal attachment of nanobodies that selectively capture EGFP ...
Ravindra K. Gupta, Hanbin Jeong, April Goehring, Eric Gouaux, Maggie He   +4 more
wiley   +1 more source

N-(2-Methoxyphenyl)benzenesulfonamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The asymmetric unit of the title compound, C(13)H(13)NO(3)S, contains two crystallographically independent mol-ecules in which the dihedral angles between the phenyl and benzene rings are 88.16 (12) and 44.50 (12)°. One of the mol-ecules features an intra-moléculaireN-HO hydrogen bond. In the crystal, the mol-ecules are linked into dimers by pairs of N-
Azizur Rehman, M. Arif Sajjad, Mehmet Akkurt, Shahzad Sharif, Muhammad Athar Abbasi, Islam Ullah Khan   +5 more
openaire   +3 more sources

Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel

, 2019
K V 3.1 blockers can serve as modulators of the rate of action potential firing in neurons with high rates of firing such as those of the auditory system. We studied the effects of several bioisosteres of N-alkylbenzenesulfonamides, and molecules derived
Passianoto, Luana Vitorino Gushiken [UNESP], González, Eduardo René Pérez, Bassetto Junior, Carlos Alberto Zanutto [UNESP], Passianoto, Luana Vitorino Gushiken, González, Eduardo René Pérez [UNESP], Bassetto Junior, Carlos Alberto Zanutto, Varanda, Wamberto Antonio   +6 more
core   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

Novel N-(Substituted) Thioacetamide Quinazolinone Benzenesulfonamides as Antimicrobial Agents

International Journal of Nanomedicine, 2020
Mostafa M Ghorab,1 Ali S Alqahtani,2,3 Aiten M Soliman,1 Ahmed A Askar4 1Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo 11765, Egypt; 2Medicinal ...
Ghorab MM, Alqahtani AS, Soliman AM, Askar AA   +3 more
doaj