Results 91 to 100 of about 2,089 (211)

Design, synthesis and QSAR-based antitumor signaling pathway analysis of pyrazoline- benzenesulfonamides mediated by cytostatic G1 arrest

Pyrazole and pyrazoline derivatives are heterocyclic compounds with notable anticancer activity, and some are already in clinical use. Although many such compounds have been reported to induce apoptosis through G2/M arrest, studies on pyrazole/pyrazoline-
KAZAZ, Cavit, Sakagami, Hiroshi, Ozgun, Dilan Ozmen, Satoh, Keitaro, GÜL, Halise İnci, Uesawa, Yoshihiro, Kurosaki, Kota, YAMALI, CEM, METE, Ebru, Amano, Shigeru   +9 more
core   +1 more source

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

, 2011
[[abstract]]A series of 7-arylindoline-1-benzenesulfonamides were prepared and evaluated for anticancer activity 7-(4'-Cyanophenyl)indoline-1-benzenesulfonamide 15 exhibited substantial antiproliferative activity with IC50 values ranging from 17-32 nM ...
Chang, JY;Lai, MJ;Chang, YT;Lee, HY;Cheng, YC;Kuo, CC;Su, MC;Chang, CY;Liou, JP
core   +1 more source

Discovery of N-(Naphtho[1,2-b]Furan-5-Yl) Benzenesulfonamides as Novel Selective Inhibitors of Triple-Negative Breast Cancer (TNBC)

Molecules, 2018
Any type of breast cancer not expressing genes of the estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2) is referred to as triple-negative breast cancer (TNBC).
Ya Chen, Yong Tang, Beibei Mao, Wenchao Li, Hongwei Jin, Liangren Zhang, Zhenming Liu   +6 more
doaj   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The synthesis of a novel series of 3-functionalised benzenesulfonamides incorporating phenyl-1,2,3-triazole with an amide linker was achieved by using the “click-tail” approach.
Baijayantimala Swain, Andrea Angeli, Srinivas Angapelly, Pavitra S. Thacker, Priti Singh, Claudiu T. Supuran, Mohammed Arifuddin   +6 more
doaj   +1 more source

Antitumor Activity of Selected Derivatives of Pyrazole- Benzenesulfonamides from Dilithiated C(α), N-Phenylhydrazones and Lithiated Methyl 2-(Aminosulfonyl)benzoate

, 2017
Several pyrazole-benzenesulfonamides were subjected to biological evaluation involving tumor formation on potato discs caused by Agrobacterium tumefaciens.
Lyles, Darby E., Pennington, William T., Camper [deceased], N. Dwight, Metz, Clyde R., Gum, James M., Beam, Charles F.   +5 more
core  

Superacid synthesized tertiary benzenesulfonamides and benzofuzed sultams act as selective hCA IX inhibitors: toward understanding a new mode of inhibition by tertiary sulfonamides

, 2013
International audienceA series of tertiary (fluorinated) benzenesulfonamides was synthesized in superacid HF-SbF5. To circumvent the problem of the in situ iminium ion formation, proved by low temperature NMR experiments, a tandem superacid catalysed ...
Daniella Vullo, Martin-Mingot, A., Agnes Martin‐Mingot, Supuran, C.T., Claudiu T. Supuran, Vullo, D., Sebastien Thibaudeau, Metayer, B., Thibaudeau, S., Benoit Metayer   +9 more
core   +1 more source

Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects.
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Ibrahim A. Al-Suwaidan   +8 more
doaj   +1 more source

Synthesis and Characterization of Celecoxib Derivatives as Possible Anti-Inflammatory, Analgesic, Antioxidant, Anticancer and Anti-HCV Agents

Molecules, 2013
A series of novel N-(3-substituted aryl/alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamides 2a–e were synthesized by the addition of ethyl a-bromoacetate and anhydrous sodium acetate in dry
Amartya Basu, Tanaji T. Talele, Neerja Kaushik-Basu, Azize Şener, Özlem Bingöl Özakpınar, Derya Özsavcı, Özge Çevik, Göknur Aktay, Şule Gürsoy, Sevil Aydın, İnci Coşkun, Ş. Güniz Küçükgüzel   +11 more
doaj   +1 more source