Results 101 to 110 of about 2,089 (211)

Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Chagas disease and leishmaniasis are neglected tropical disorders caused by the protozoans Trypanosoma cruzi and Leishmania spp. Carbonic anhydrases (CAs, EC 4.2.1.1) from these protozoans (α-TcCA and β-LdcCA) have been validated as promising targets for
Alessio Nocentini, Sameh M. Osman, Igor A. Rodrigues, Veronica S. Cardoso, Fatmah Ali S. Alasmary, Zeid AlOthman, Alane B. Vermelho, Paola Gratteri, Claudiu T. Supuran   +8 more
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Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

Chemistry Central Journal, 2017
Background A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a–t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate aromatic amine.
Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz, Mahmoud M. Elaasser   +5 more
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The anticholinesterase perspective of dimethoxyindole based benzenesulfonamides: Synthesis, biological investigation and molecular docking applications

Due to the well-known biological potential of benzenesulfonamides for the inhibition of specific enzymes, here in, we propose to investigate anticholinesterase efficiencies of five newly synthesized benzenesulfonamides incorporating dimethoxyindole tails.
Akocak, Süleyman, Ercan, Selami, Bingül, Alev Arslantürk, Arslan, Zehra, Şengül, İbrahim Fazıl, Bingül, Murat, Şahin, Hasan, Boǧa, Mehmet, Tuneğ, Muhammed   +8 more
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Primary sulfonamide as a coupling partner: Copper(I)-catalyzed regioselective cross-coupling of 2-nitro benzenesulfonamides with thiol through the cleavage of Ar–SO₂NH₂ bonds

, 2018
In this article, we have presented a novel and efficient method for the direct synthesis of unsymmetrical sulfides through the copper(I)-catalyzed cross-coupling of 2-nitro benzenesulfonamides with thiols in the presence of catalytic amount of CuI in DMF
Yongli Zhao (2850701), Junmin Chen (625300), Shouzhi Pu (1826455), Kuo Zhang (337825)   +3 more
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Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides

Molecules, 2015
A series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids.
Beata Żołnowska, Jarosław Sławiński, Mariusz Belka, Tomasz Bączek, Anna Kawiak, Jarosław Chojnacki, Aneta Pogorzelska, Krzysztof Szafrański   +7 more
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Natural-abundance nitrogen-15 nuclear magnetic resonance spectroscopy. Electronic effects in benzenesulfonamides

, 1978
The ^(15)N chemical shifts of a number of benzenesulfonamides with different substituents at nitrogen have been measured in dimethyl sulfoxide solution and compared to those of similarly substituted benzenamines and ethanamides.
Roberts, John D., Doss, Senot H., Schuster, Ingeborg I.   +2 more
core  

1,3,5-Triazine-benzenesulfonamide hybrids: are they cytotoxic?

European Journal of Pharmaceutical Sciences
In contemporary pharmaceutical research, cytotoxicity assays constitute an indispensable tool in the systematic evaluation of drug candidates. The identification of cytotoxic effects at early stages of development is critical, as it allows for the elimination of compounds with unfavourable toxicological properties prior to their advancement into ...
Mária Bodnár Mikulová, Jana Hricovíniová, Michal Hanko, Gabriela Greifová   +3 more
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New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides

, 2013
International audienceTertiary substituted (fluorinated) benzenesulfonamides were synthesized in superacid HF/SbF5 and tested as inhibitors of human carbonic anhydrases (hCAs, EC 4.2.1.1).
Mingotti, A., Supuran, C., T., Vullo, D., Metayer, B., Thibaudeau, S.   +4 more
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Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents

[EN]Agents that cause apoptotic cell death by interfering with tubulin dynamics, such as vinblastine and paclitaxel, are an important class of chemotherapeutics.
Peláez Lamamie de C. Arroyo, Rafael, Hanes, Robert, Fuentes-Martín, Raúl, Fuentes Martín, Raúl, Gallego-Yerga, Laura, Ayuda-Durán, Pilar, Wolterinck, Lisanne, Álvarez Lozano, Raquel, Álvarez, Raquel, Ayuda Durán, Pilar, Enserink, Jorrit M., Peláez, Rafael   +11 more
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Synthesis and Biological Evaluation of N- Pyrazolyl Derivatives and Pyrazolopyrimidine Bearing a Biologically Active Sulfonamide Moiety as Potential Antimicrobial Agent

Molecules, 2016
A series of novel pyrazole-5-carboxylate containing N-triazole derivatives 3,4; different heterocyclic amines 7a–b and 10a–b; pyrazolo[4,3-d]pyrimidine containing sulfa drugs 14a,b; and oxypyrazolo[4,3-d]pyrimidine derivatives 17, 19, 21 has been ...
Hend N. Hafez, Abdel-Rhman B.A. El-Gazzar   +1 more
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