Results 111 to 120 of about 2,089 (211)

Investigation of benzenesulfonamides, bearing modified glycine fragment, as human carbonic anhydrase inhibitors.

, 2022
Carbonic anhydrase enzymes catalyze reversible carbon dioxide hydration to bicarbonate and protons. There are 15 different CA isoforms in human body, 12 of them are catalytically active.
Bagdonas, Martynas,
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Development of New Benzenesulfonamides As Potent and Selective Na_v1.7 Inhibitors for the Treatment of Pain

, 2017
By taking advantage of certain features in piperidine 4, we developed a novel series of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Nav1.7 inhibitors.
Yong-Jin Wu (1442710), Richard Olson (1601506), Michele Matchett (1445923), Jianliang Shi (1442734), Debra J. Post-Munson (3012747), John Graef (3827284), James Herrington (2553397), Kevin J. Robbins (1276632), Kathleen Mosure (3827272), Kimberly Newberry (3827275), Lorin A. Thompson (1442737), Amy Newton (3827278), Matthew G. Soars (3827281), Ronald J. Knox (3017028), Nicholas A. Meanwell (362044), Rick L. Pieschl (3225318), Clotilde Bourin (621353), Jason Guernon (1442731), Ramkumar Rajamani (1442725), Linda J. Bristow (2586349), Jonathan Ditta (3064554), Carolyn Dzierba (2159917), Shuya Wang (2158342), Amy Easton (621347)   +23 more
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Synthesis, Anticancer Evaluation and Structure-Activity Analysis of Novel (E)- 5-(2-Arylvinyl)-1,3,4-oxadiazol-2-yl)benzenesulfonamides

, 2020
To learn more about the structure–activity relationships of (E)-3-(5-styryl-1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives, which in our previous research displayed promising in vitro anticancer activity, we have synthesized a group of novel ...
Krzysztof Szafrański, Anna Kawiak, Jarosław Sławiński, Łukasz Tomorowicz   +3 more
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Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects

, 2016
In this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by H-1 NMR, (CNMR)-C-13, and HRMS.
Taslımı, Parham, Gul, Halise Inci, Taslimi, Parham, Ozturk, Iknur, Bilginer, Sinan, Supuran, Claudiu T., Gülçin, İlhami, Yamali, Cem, Kucukoglu, Kaan, Yamalı, Cem, Yuca, Hafize   +10 more
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Synthesis and Evaluation of Cytotoxic Activity of Substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides

, 2013
Several novel N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides derivatives were prepared as potential antiproliferative agents. The in vitro antiproliferative activity of the synthesized compounds was investigated against a panel of tumor cell lines ...
Asd, Shaaban, Safavi, Maliheh, Ardestani, Sussan Kabudanian, Shafiee, Abbas, Foroumadi, Alireza, Parang, Keykavous, Oh, Donghoon, Shirazi, Amir Nasrolahi, Pordeli, Mahboobeh, Akbarzadeh, Tahmineh, Maleki, Saeedeh, Motavallizadeh, Somayeh, Asal Fallah-Taftia, Asal, Tiwari, Rakesh, Fallah-Tafti, Asal   +14 more
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Benzenesulfonamide

Acta Crystallographica Section E Structure Reports Online, 2007
B. Thimme Gowda, Roopa Nayak, Jozef Kožíšek, Miroslav Tokarčík, Hartmut Fuess   +4 more
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Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases

, 2015
Substituted tri- and tetrafluorobenzenesulfonamides were designed, synthesized, and evaluated as high-affinity and isoform-selective carbonic anhydrase (CA) inhibitors.
Smirnov, Alexey, Elena Manakova, David D. Timm, Daumantas Matulis, Audrius Zakšauskas, Joana Smirnovienė, Timm, David D., Justina Kazokaitė, Zubrienė, Asta, Matulis, Daumantas, Smirnovienė, Joana, Kazokaitė, Justina, Gražulis, Saulius, Vilma Michailovienė, Saulius Gražulis, Zakšauskas, Audrius, Manakova, Elena, Asta Zubrienė, Dudutienė, Virginija, Virginija Dudutienė, Michailovienė, Vilma, Alexey Smirnov   +21 more
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The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships

, 1989
Molecular mechanics methods have been applied to study the interaction between a series of 20 deprotonated benzenesulfonamides and the enzyme carbonic anhydrase.
F. Gago, W. G. Richards, MENZIANI, Maria Cristina, DE BENEDETTI, Pier Giuseppe   +3 more
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Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases.

, 2012
A series of [(2-pyrimidinylthio)acetyl]benzenesulfonamides were designed and synthesized. Their binding affinities as inhibitors of several recombinant human carbonic anhydrase (CA) isozymes were determined by isothermal titration calorimetry (ITC) and ...
Kairys, V., Tumkevicius, S., Zubriene, A., Baranauskiene, L., Tamulaitiene, G., Manakova, E., Grazulis, S., Capkauskaite, E., Matulis, D.   +8 more
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Bis-Ureido-Substituted Benzenesulfonamides: Evaluation of Their Antibacterial, Anticholinesterase, and Cytotoxicity Properties

In this study, we present the re-synthesis of a series of twelve bis-ureido-substituted benzenesulfonamides, focusing on their potential as antibacterial, anticholinesterase, and cytotoxic agents.
Tekeli, Yener, Lolak, Nebih, Tekeli, Tuba, AKIN ANAKÖK, DENİZ, GÜLÇİN, İlhami, Bozgeyik, Esra, Akocak, Suleyman, ÇETE, SERVET   +7 more
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