Results 81 to 90 of about 2,089 (211)

Probing the chemical interaction space governed by 4-amino-substituted benzenesulfonamides and carbonic anhydrase isoforms

Research in Pharmaceutical Sciences, 2018
Isoform diversity, critical physiological roles and involvement in major diseases/disorders such as glaucoma, epilepsy, Alzheimer's disease, obesity, and cancers have made carbonic anhydrase (CA), one of the most interesting case studies in the field of ...
Behnam Rasti, Yeganeh Entezari Heravi
doaj   +1 more source

CBr4‐Mediated Metal‐Free Sulfonamide Synthesis: A Comparative Study Under Batch, Continuous‐Flow and Ultrasonic Conditions

Asian Journal of Organic Chemistry, Volume 15, Issue 4, April 2026.
A practical and efficient CBr4‐mediated metal‐free route for sulfonamide synthesis is presented under batch, ultrasonic, and continuous‐flow conditions. The protocol demonstrates excellent substrate scope, reduced reaction times, and mild operating conditions, highlighting a scalable alternative to traditional iodine‐mediated methods in modern ...
Alageswaran Jayaram, Vijay Thavasianandam Seenivasan, Yu‐Ming Liu, Yu‐Chen Lin, Tsz‐Fai Leung, Ching‐Ching Yu, Wei‐Yu Lin   +6 more
wiley   +1 more source

3,5-Dichloro-N-(2,4-dichlorophenyl)benzenesulfonamide [PDF]

IUCrData, 2017
The molecule of the title compound, C12H7Cl4NO2S, is U-shaped, with the central C—S—N—C segment having a torsion angle of −58.7 (3)°. The dihedral angle between the benzene rings is 40.23 (2)°. Further, the ortho Cl atom on the aniline ring is syn to the N—H bond in the central –C—S(O2)—NH—C– segment.
K. Shakuntala, N. K. Lokanath, S. Naveen, P. A. Suchetan   +3 more
openaire   +3 more sources

Extraction of benzothiazoles, benzotriazoles and benzenesulfonamides from environmental water

Validation parameters (apparent recoveries and matrix effect) to be able to determine a group of benzothiazoles, benzotriazoles and benzenesulfonamides from environmental water including river, effluent and influent sewage samples.
Marcé-Recasens, Rosa Maria, Fontanals Torroja, Núria, Moral Ruiz, Alberto, Borrull, Francesc   +3 more
core   +1 more source

Bimetallic M2B Boride Nanoparticles: A Robust and Recyclable Platform for Dehydration‐Driven Condensation of Aldehydes

ChemistryOpen, Volume 15, Issue 4, April 2026.
Metal borides (MBs) emerge as a versatile class of nanomaterials, featuring high stability and bifunctional Lewis‐acidic/basic active sites. Despite these properties, their applications in CN bond formation are less explored. Herein, we report the first systematic use of M2B‐type boride nanoparticles as efficient and magnetically recoverable catalysts
Akram Ashouri, Arezu Moradi, Behzad Nasiri, Somayeh Pourian, Hossein Zamani, Fatemeh Rezaei, Amin Karimizadeh   +6 more
wiley   +1 more source

Determination of benzothiazoles, benzotriazoles and benzenesulfonamides in fish

Validation parameters that include instrumental validation (linear range and determination coefficient) and method validation (apparent recoveries and method of quantification and detection) for the determination of benzothiazoles, benzotriazoles and ...
Borrull, Francesc, Pocurull, Eva
core   +1 more source

Interaction of β and γ aminoacid substituted benzenesulfonamides with human carbonic anhydrases.

, 2022
Carbonic anhydrases (CAs; EC 4.2.1.1) are zinc metalloenzymes, of which 12 catalytically active isoforms are found in humans. Abnormal expression of some CAs is related to various disorders such as different types of cancer, glaucoma, obesity, epilepsy ...
Šimkūnas, Tomas,
core  

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
4-(3-(4-Substituted-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamides (9–16) were successfully synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, and HRMS spectra.
Halise Inci Gul, Ebru Mete, Parham Taslimi, Ilhami Gulcin, Claudiu T. Supuran   +4 more
doaj   +1 more source

Novel Application of UHPLC–MS, HRMS, and 2D‐NMR for Structural Elucidation of Eletriptan Hydrobromide and Its Novel Degradation Products

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT A stability‐indicating UHPLC–MS method was developed to investigate the stress degradation behavior of eletriptan hydrobromide under ICH‐recommended acidic, alkaline, neutral, oxidative, thermal, and photolytic conditions. Significant degradation was observed only under acidic and oxidative stress.
Dastagiri Reddy Bhuma, Venkata Kanaka Srivani Maddala, Suresh Salakolasu, Naresh Kumar Katari   +3 more
wiley   +1 more source