Results 161 to 170 of about 40,476 (314)
Cyclodextrin‐Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery
Small, EarlyView.Host–guest interactions between cyclodextrin (CD) and compatible guest molecules enable the formation of diverse architectures, such as multiblock and linear–star copolymers as well as advanced systems like redox‐responsive nanoparticles. This structural versatility facilitates precise system design, conferring multifunctionality for controlled drug ...
Wilson Wee Mia Soh, Jun Li
wiley +1 more source
2D Materials: From Design and Synthesis to Applications in Electrical and Electrochemical Biosensors
Small, EarlyView.Various types of 2D materials, encompassing all potential candidates to date, are examined alongside their synthetic methods and functionalization strategies for bioreceptor immobilization. This review highlights approaches for designing and scaling up these materials to enable cost‐effective electrical and electrochemical biosensing applications ...
Masud +3 more
wiley +1 more source
Synthesis of S-(4-Aryl-4H-1,2,4-Triazol-3yl) 2-Mercaptomethyl Benzimidazoles [PDF]
, 1977 K. F. MODI +4 more
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Aging Cell, EarlyView.Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun +13 more
wiley +1 more source
Structure‐based discovery of thiamine uptake inhibitors
British Journal of Pharmacology, EarlyView.Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel +2 more
wiley +1 more source
Conformation of nucleosides: circular dichroism study on the syn-anti conformational equilibrium of 2-substituted benzimidazole nucleosides. [PDF]
, 1979 Daniel W. Miles +3 more
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Trends in novel opioid use and detections in exposures and police drug seizures in New South Wales
Drug and Alcohol Review, EarlyView.Abstract Introduction Novel opioids, including non‐medical and non‐opium‐based opioids such as fentanyl analogues and nitazenes, pose a significant risk of harm due to their high potency. There is little published data on novel opioid detections and harms in Australia, yet they are implicated in multiple deaths.
Janette L. Smith +7 more
wiley +1 more source