Results 1 to 10 of about 214,407 (289)

GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

Frontiers in Psychiatry, 2023
Benzodiazepines have been in use for over half a century. While they remain highly prescribed, their unfavorable side-effect profile and abuse liability motivated a search for alternatives.
Elif Engin, Elif Engin
doaj   +2 more sources

Benzodiazepine use in physicians: retrospective 5-year nationwide study in Taiwan [PDF]

BJPsych Open
Background Benzodiazepine use among physicians is an important public health issue related to physicians’ well-being and patient safety. Aims This study aimed to evaluate the patterns and correlates of benzodiazepine use in physicians by comparing ...
Wan-Ju Cheng, Yin-Chieh Chuang, Hsuan-Ching Wang, Hei-Tung Yip, Cheng-Li Lin, Cynthia Wei-Sheng Lee   +5 more
doaj   +2 more sources

Benzodiazepines Misuse [PDF]

Indian Journal of Psychological Medicine, 2011
Viroj Wiwanitkit
openalex   +5 more sources

Long-term consequences of benzodiazepine-induced neurological dysfunction: A survey.

PLoS ONE, 2023
BackgroundAcute benzodiazepine withdrawal has been described, but literature regarding the benzodiazepine-induced neurological injury that may result in enduring symptoms and life consequences is scant.ObjectiveWe conducted an internet survey of current ...
Alexis D Ritvo, D E Foster, Christy Huff, A J Reid Finlayson, Bernard Silvernail, Peter R Martin   +5 more
doaj   +3 more sources

Supporting safe and gradual reduction of long‐term benzodiazepine receptor agonist use: Development of the SAFEGUARDING‐BZRAs toolkit using a codesign approach

Health Expectations, 2022
Introduction Long‐term benzodiazepine receptor agonist (BZRA) use persists in healthcare settings worldwide and poses risks of patient harm. Objective This study aimed to develop an intervention to support discontinuation of long‐term BZRA use among ...
Tom Lynch, Cristín Ryan, Colin Bradley, D. Foster, Christy Huff, Sharon Hutchinson, Nicole Lamberson, Lily Lynch, Cathal Cadogan   +8 more
doaj   +1 more source

Exploring trends in benzodiazepine-positive fatal drug overdoses in Tennessee, 2019–2021

Annals of Medicine, 2023
Background Benzodiazepine-positive overdoses increased between 2019 and 2021 in Tennessee. We sought to determine the changes in the number and characteristics of prescription and illicit benzodiazepine-positive fatal drug overdoses during this period ...
Jenna Moses, Jessica Korona-Bailey, Sutapa Mukhopadhyay   +2 more
doaj   +1 more source

A review on the chemistry and pharmacological properties of benzodiazepine motifs in drug design

Arab Journal of Basic and Applied Sciences, 2022
Benzodiazepines are an important class of heterocyclic compounds in organic chemistry. They are known for their diverse physicochemical and biological properties.
Olayinka O. Tolu-Bolaji, Samuel O. Sojinu, Adebola P. Okedere, Olayinka O. Ajani   +3 more
doaj   +1 more source

Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life [PDF]

, 2003
Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years.
Collins, R., Curran, H.V., Fletcher, S., Iliffe, S., Kee, S.C.Y., Woods, B.   +5 more
core   +1 more source

Epidemiologic assessment of benzodiazepine exposure among suicide deaths in Colorado, 2015–2017

BMC Public Health, 2020
Background Suicide rates have been climbing in the U.S., particularly in Rocky Mountain states such as Colorado. Benzodiazepines have been linked with suicidal ideation, but there have been few population level assessments of this link.
Tista Ghosh, Kirk Bol, Maria Butler, Barbara Gabella, Andrea Kingcade, Gabriel Kaplan, Lindsey Myers   +6 more
doaj   +1 more source

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
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