Results 41 to 50 of about 214,407 (289)

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study

British medical journal, 2015
Objective To study the association between benzodiazepine prescribing patterns including dose, type, and dosing schedule and the risk of death from drug overdose among US veterans receiving opioid analgesics. Design Case-cohort study.
Tae Woo Park, R. Saitz, D. Ganoczy, M. Ilgen, A. Bohnert   +4 more
semanticscholar   +1 more source

The Prevalence of Benzodiazepine Usage Among Cardiovascular Patients [PDF]

مجله علوم پزشکی صدرا
Introduction: Both benzodiazepines and cardiovascular disease independently increase dementia risk, while anxiety and other psychiatric disorders may exacerbate cardiovascular diseases.
Vahid Mohammadkarimi, Pariya Kouhi, Noushafarin Baziar, Javad Kojuri, Nazanin Hosseini, Reza Golchin Vafa, Mohammad Montaseri, Ebrahim Moghimi Sarani   +7 more
doaj   +1 more source

Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Case Reports in Nephrology and Dialysis, 2022
Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient.
Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar   +4 more
doaj   +1 more source

Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. [PDF]

, 2017
ObjectiveTo evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).MethodsRats were treated with BRV (10 mg/kg) 10 min after ...
Alldredge, Biton, Brophy, Chen, Coeytaux, DeLorenzo, FDA, Gezalian, Gillard, Glauser, Griffin, Klein, Klein, Klein, Klitgaard, Klitgaard, Matagne, Matagne, Mazarati, Mazarati, Mazarati, Naylor, Nicolas, Reagan-Shaw, Ryvlin, Sanchez, Silbergleit, Stockis, Suchomelova, Treiman, Trinka, Wasterlain, Wood   +32 more
core   +1 more source

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

British medical journal, 2016
Objective To determine whether higher cumulative use of benzodiazepines is associated with a higher risk of dementia or more rapid cognitive decline. Design Prospective population based cohort.
S. Gray, S. Dublin, Onchee Yu, Rod L. Walker, Melissa L. Anderson, R. Hubbard, P. Crane, E. Larson   +7 more
semanticscholar   +1 more source

‘We need more support and doctors that understand the process of tapering …’: A content analysis of free‐text responses to a questionnaire on discontinuing long‐term benzodiazepine receptor agonist use

Health Expectations
Background Many individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented ...
Tom Lynch, Cristín Ryan, Christy Huff, D. E. Foster, Cathal Cadogan   +4 more
doaj   +1 more source

Influence of SSRI and SNRI co-prescription on benzodiazepine prescription trajectories

Drug and Alcohol Dependence Reports
Purpose: This study examined whether co-prescription of selective serotonin reuptake inhibitors (SSRIs) or serotonin or norepinephrine reuptake inhibitors (SNRI)s with benzodiazepines is associated with differences in benzodiazepine prescriptions both ...
Kerry L. Kinney, Eliseu da Cruz Moreira-Junior, Laís F. Berro, Matthew C. Morris, James K. Rowlett   +4 more
doaj   +1 more source

Predicting benzodiazepine prescriptions: A proof-of-concept machine learning approach

Frontiers in Psychiatry, 2023
IntroductionBenzodiazepines are the most commonly prescribed psychotropic medications, but they may place users at risk of serious adverse effects. Developing a method to predict benzodiazepine prescriptions could assist in prevention efforts.MethodsThe ...
Kerry L. Kinney, Kerry L. Kinney, Yufeng Zheng, Yufeng Zheng, Matthew C. Morris, Matthew C. Morris, Julie A. Schumacher, Julie A. Schumacher, Saurabh B. Bhardwaj, Saurabh B. Bhardwaj, James K. Rowlett, James K. Rowlett   +11 more
doaj   +1 more source

Reducing Benzodiazepine Use for the Treatment of Insomnia and Supporting Nonpharmacological Therapies [PDF]

, 2019
Most medical organizations recommend against the use of benzodiazepine use for the treatment of insomnia, especially in the elderly. However, the percentage of the adult population on benzos increase with age: 7.5% in adults ages 51-64; 9% in adults over
Pyon, UnChan
core   +1 more source