Results 41 to 50 of about 123,980 (206)

Benzodiazepine Use Disorder Observed and Diagnosed in a Tertiary Care Pediatric Specialty Clinic: A Descriptive Retrospective Chart Review

BJPsych Open
Aims Objectives: In youth and young adults, it is common to encounter non-medical use of benzodiazepines, defined as use without a prescription or use for reasons other than that for which the medication is intended.
Alex Smithers, Laura Miller, Melanie MacInnis, Selene Etches   +3 more
doaj   +1 more source

Benzodiazepine usage and patient preference for alternative therapies: A descriptive study

Health Science Reports, 2019
Background and aims The prevalence of chronic benzodiazepine use in primary care settings remains high despite clear evidence of adverse health outcomes resulting from long‐term use and the availability of effective alternative behavioural therapies ...
Fatema‐Tun‐Naher Sake, Keith Wong, Delwyn J. Bartlett, Bandana Saini   +3 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of (4Z)-1-butyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2018
The asymmetric unit of the title compound, C16H20N2O2, consists of two independent molecules differing slightly in the conformations of the seven-membered rings and the butyl substituents, where the benzene rings are oriented at a dihedral angle of 34.56 
Karim Chkirate, Nada Kheira Sebbar, Tuncer Hökelek, Damodaran Krishnan, Joel T. Mague, El Mokhtar Essassi   +5 more
doaj   +1 more source

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA_A Receptors

Brain Sciences, 2020
Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian, Yan-Qing Cao, Yu-Lei Li, Gang Yu, Rui-Bin Su   +4 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 3,4-dihydro-2-(2,4-dioxo-6-methylpyran-3-ylidene)-4-(4-pyridin-4-yl)-1,5-benzodiazepine

Acta Crystallographica Section E: Crystallographic Communications, 2019
The title compound, C20H17N3O3 [systematic name: 2-(6-methyl-2,4-dioxopyran-3-ylidene)-4-(pyridin-4-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine], is built up from a benzodiazepine ring system linked to pyridyl and pendant dihydropyran rings, where the ...
Lhoussaine El Ghayati, Youssef Ramli, Tuncer Hökelek, Mohamed Labd Taha, Joel T. Mague, El Mokhtar Essassi   +5 more
doaj   +1 more source

Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Case Reports in Nephrology and Dialysis, 2022
Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient.
Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar   +4 more
doaj   +1 more source

Benzodiazepine use, misuse, and abuse: A review

Mental Health Clinician, 2016
Benzodiazepine (BZD) abuse has reached epidemic levels and results in poor outcomes, particularly when combined with concomitant central nervous system depressants. BZDs are abused most commonly in combination with opioids and alcohol.
Allison Schmitz
semanticscholar   +1 more source

Zolpidem Profoundly Augments Spared Tonic GABAAR Signaling in Dentate Granule Cells Ipsilateral to Controlled Cortical Impact Brain Injury in Mice

Frontiers in Systems Neuroscience, 2022
Type A GABA receptors (GABAARs) are pentameric combinations of protein subunits that give rise to tonic (ITonicGABA) and phasic (i.e., synaptic; ISynapticGABA) forms of inhibitory GABAAR signaling in the central nervous system.
Jeffery A. Boychuk, Jeffery A. Boychuk, Corwin R. Butler, Corwin R. Butler, Katalin Cs. Smith, Katalin Cs. Smith, Miklos B. Halmos, Bret N. Smith, Bret N. Smith, Bret N. Smith, Bret N. Smith   +10 more
doaj   +1 more source

Assessing the clinical utility of the severity dependence scale for benzodiazepine use disorder

South African Journal of Psychiatry, 2021
Background: Benzodiazepines are often used as a part of mental health pharmacological management; however, often when prescribed for extended periods, they increase the risk of benzodiazepine use disorder (BUD).
Karishma Lowton, Gaveeta Chiba
doaj   +1 more source

Simultaneous Antidepressant and Benzodiazepine New Use and Subsequent Long-term Benzodiazepine Use in Adults With Depression, United States, 2001-2014

JAMA psychiatry, 2017
Importance Benzodiazepines have been prescribed for short periods to patients with depression who are beginning antidepressant therapy to improve depressive symptoms more quickly, mitigate concomitant anxiety, and improve antidepressant treatment ...
G. Bushnell, T. Stürmer, B. Gaynes, V. Pate, Matthew Miller   +4 more
semanticscholar   +1 more source