Results 51 to 60 of about 138,894 (338)

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

British medical journal, 2016
Objective To determine whether higher cumulative use of benzodiazepines is associated with a higher risk of dementia or more rapid cognitive decline. Design Prospective population based cohort.
S. Gray, S. Dublin, Onchee Yu, Rod L. Walker, Melissa L. Anderson, R. Hubbard, P. Crane, E. Larson   +7 more
semanticscholar   +1 more source

‘We need more support and doctors that understand the process of tapering …’: A content analysis of free‐text responses to a questionnaire on discontinuing long‐term benzodiazepine receptor agonist use

Health Expectations
Background Many individuals worldwide continue to take benzodiazepine receptor agonists (BZRAs) long term (≥3 months). The aim of this study was to conduct a content analysis of the views and experiences of discontinuing long‐term BZRA use as documented ...
Tom Lynch, Cristín Ryan, Christy Huff, D. E. Foster, Cathal Cadogan   +4 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of (4Z)-1-butyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2018
The asymmetric unit of the title compound, C16H20N2O2, consists of two independent molecules differing slightly in the conformations of the seven-membered rings and the butyl substituents, where the benzene rings are oriented at a dihedral angle of 34.56 
Karim Chkirate, Nada Kheira Sebbar, Tuncer Hökelek, Damodaran Krishnan, Joel T. Mague, El Mokhtar Essassi   +5 more
doaj   +1 more source

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA_A Receptors

Brain Sciences, 2020
Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner, possibly ...
Jing-Jing Lian, Yan-Qing Cao, Yu-Lei Li, Gang Yu, Rui-Bin Su   +4 more
doaj   +1 more source

Use of the R-group descriptor for alignment-free QSAR [PDF]

, 2005
An R-group descriptor characterises the distribution of some atom-based property, such as elemental type or partial atomic charge, at increasing numbers of bonds distant from the point of substitution on a parent ring system. Application of Partial Least
Gedeck, P., Hirons, L., Holliday, J.D., Jelfs, S.P., Willett, P.   +4 more
core   +1 more source

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources

Prevalence and Correlates of Benzodiazepine Use, Misuse, and Use Disorders Among Adults in the United States.

Journal of Clinical Psychiatry, 2018
OBJECTIVE Although benzodiazepine misuse and use disorders are associated with adverse health effects, it is unknown what proportion of benzodiazepine users misuse them or meet criteria for benzodiazepine use disorders.
C. Blanco, B. Han, Christopher M. Jones, Kimberly A Johnson, W. Compton   +4 more
semanticscholar   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

Benzodiazepine Use Disorder Observed and Diagnosed in a Tertiary Care Pediatric Specialty Clinic: A Descriptive Retrospective Chart Review

BJPsych Open
Aims Objectives: In youth and young adults, it is common to encounter non-medical use of benzodiazepines, defined as use without a prescription or use for reasons other than that for which the medication is intended.
Alex Smithers, Laura Miller, Melanie MacInnis, Selene Etches   +3 more
doaj   +1 more source

Benzodiazepine usage and patient preference for alternative therapies: A descriptive study

Health Science Reports, 2019
Background and aims The prevalence of chronic benzodiazepine use in primary care settings remains high despite clear evidence of adverse health outcomes resulting from long‐term use and the availability of effective alternative behavioural therapies ...
Fatema‐Tun‐Naher Sake, Keith Wong, Delwyn J. Bartlett, Bandana Saini   +3 more
doaj   +1 more source