Results 51 to 60 of about 98,405 (294)

Cannabidiol Lacks Direct Effect on Cortical Excitability: A Randomized, Double Blind, Placebo Controlled, 3‐Way Crossover Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is approved as an adjunctive treatment of seizures associated with Dravet syndrome, Lennox–Gastaut Syndrome, and tuberous sclerosis. Its therapeutic and adverse effects are thought to arise, at least partly, from a pharmacokinetic interaction with clobazam, another anti‐seizure medication (ASM).
Andriy A. Gorbenko, Catherine M.K.E. de Cuba, Annika A. de Goede, Titiaan E. Post, Roman Bohoslavsky, Pamela K. Strugala, Jules A.A.C. Heuberger, Geert Jan Groeneveld   +7 more
wiley   +1 more source

Addressing the Issue of Chronic, Inappropriate Benzodiazepine Use: How Can Pharmacists Play a Role?

Pharmacy, 2013
Prescribing guidelines do not recommend the long-term use of benzodiazepines since their effectiveness with chronic use is out-weighed by risks including dependence, memory and cognitive impairment, hip fractures and traffic accidents.
Helen C. Gallagher
doaj   +1 more source

Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia

Frontiers in Psychiatry, 2020
ObjectivesChronic use of benzodiazepines and zolpidem (BDZ/Z-drugs) leads to dependency, cognitive impairment, and falls. Although controlled-release melatonin (Melatonin CR) may be an alternative, a switch in clinical settings has proven difficult.
Ji Hyun An, Mi Jin Park, Maurizio Fava, David Mischoulon, Hyewon Kim, Jihoon Jang, Jin Pyo Hong, Jun Sang Park, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon   +11 more
doaj   +1 more source

Pharmacomicrobiomics

Clinical Pharmacology &Therapeutics, EarlyView.
Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich, Naama Geva‐Zatorsky, Rachel Herren, Libusha Kelly, Ziv Cohen, Haiying Zhou, Yi‐Ching Chen, Khalid Shah, Talin A. Robinson‐Catala, Grecia Frisby, Jason H. Karnes, Lisl Shoda   +11 more
wiley   +1 more source

Post‐Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne

Drug Testing and Analysis, EarlyView.
In early 2025, five death cases in Finland tested positive for fluetonitazepyne and one for isotonitazepyne in urine drug screening. A peak corresponding to O‐dealkylated fluetonitazepyne, the 4‐OH‐nitazepyne metabolite, was present in all fluetonitazepyne‐positive urine samples and was later used in the identification of isotonitazepynein one fatal ...
Pirkko Kriikku, Anna Pelander, Antti Jylhä, Ilkka Ojanperä   +3 more
wiley   +1 more source

Parenting Stress in Adolescent Anorexia Nervosa: Differential Stress in Mothers and Fathers During Inpatient Treatment

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder that impacts both the adolescents themselves and their parents. Parenting stress is associated with impaired mental health of parents and poorer treatment outcomes for their children.
V. Stonawski, J. Kutzner, S. Büscher, A. Hoyer, O. Kratz, S. Horndasch   +5 more
wiley   +1 more source

Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus

Epileptic Disorders, EarlyView.
Abstract This case study reports the first documented use of stereoelectroencephalography (SEEG)‐guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33‐year‐old woman with drug‐resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone.
Odile Feys, Julia Makhalova, Thomas Manners, José‐David Herrera‐García, Romain Carron, Fabrice Bartolomei   +5 more
wiley   +1 more source

Unmet needs of women with epilepsy living in rural low‐ and middle‐income countries: The experience of the Bolivian Chaco

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 70 million people worldwide, with 80% living in low‐ and middle‐income countries (LMICs), where many people with epilepsy (PWE) go undiagnosed or untreated. Over the last few decades, many efforts have been made worldwide to reduce the treatment gap (TG) in LMICs.
Alessandra Nicoletti, Gianluca Latino, Calogero Edoardo Cicero, Anna Barbiero, Chiara Aguzzoli, Bianca Ribelli, Valentina Petrini, Maria Micieli, Sandra Padilla, Estela Vilte, Francesco Cosmi, Elizabeth Blanca Crespo Gomez, Alessandro Bartoloni, Loretta Giuliano   +13 more
wiley   +1 more source

Benzodiazepine abuse among the elderly

Journal of Geriatric Mental Health, 2016
Benzodiazepines belong to the hypnotic-sedative class of drugs which have anxiolytic, sedative, and hypnotic properties. These drugs have been in clinical use for at least half a century.
Shalini Singh, Siddharth Sarkar
doaj   +1 more source

Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future

Epilepsia Open, EarlyView.
Abstract Electroencephalography (EEG) has evolved into an indispensable tool in pediatric epilepsy, fundamentally transforming the diagnosis, classification, and management of this condition. This review chronicles the historical journey of EEG from its groundbreaking inception to its current pivotal role in delineating distinct pediatric epilepsy ...
Hiroki Nariai
wiley   +1 more source