Results 51 to 60 of about 123,980 (206)

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Molecules, 2014
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing ...
Marcus Baumann, Ian R. Baxendale, Christian H. Hornung, Steven V. Ley, Maria Victoria Rojo, Kimberley A. Roper   +5 more
doaj   +1 more source

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Frontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Ulrich Frischknecht, Derik Hermann, Derik Hermann, Falk Kiefer, Gabriele Ende, Markus Sack   +8 more
doaj   +1 more source

The effect of lemborexant on insomnia in patients with psychiatric disorders: Detailed evaluation using the Athens Insomnia Scale

PCN Reports
Aim Chronic insomnia disorder is common and associated with reduced quality of life. Benzodiazepine hypnotics are commonly prescribed for insomnia, but have potential side effects such as concentration impairment, somnolence, and dependence. Lemborexant (
Tomonori Murayama, Yuji Ito, Kenji Narita, Tetsuro Ishida, Shiro Hinotsu, Masahiko Fujita   +5 more
doaj   +1 more source

Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia

Frontiers in Psychiatry, 2020
ObjectivesChronic use of benzodiazepines and zolpidem (BDZ/Z-drugs) leads to dependency, cognitive impairment, and falls. Although controlled-release melatonin (Melatonin CR) may be an alternative, a switch in clinical settings has proven difficult.
Ji Hyun An, Mi Jin Park, Maurizio Fava, David Mischoulon, Hyewon Kim, Jihoon Jang, Jin Pyo Hong, Jun Sang Park, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon   +11 more
doaj   +1 more source

Five traits of personality in benzodiazepine-dependent patients with bipolar disorder

European Psychiatry, 2021
Introduction Benzodiazepines (BZD) are frequently prescribed to patients with bipolar disorder. The use of this medication can become problematic in some cases or even lead to dependence mainly in patients with personality disorders.
N. Charfi, M. Ben Abdallah, S. Omri, R. Feki, N. Smaoui, L. Zouari, J. Ben Thabet, M. Maalej Bouali, M. Maalej   +8 more
doaj   +1 more source

Benzodiazepine maintenance for alcohol dependence: A case series

Journal of Family Medicine and Primary Care, 2017
Alcohol addiction is a chronic relapsing syndrome. Benzodiazepines remain as the mainstay for detoxification, taking care of the acute withdrawal syndrome. There is fear of dependence and abuse of benzodiazepines on prolonged use.
Shivanand Kattimani, Balaji Bharadwaj, Anand Babu Arun   +2 more
doaj   +1 more source

Preliminary Investigation of Pharmacist-Delivered, Direct-to-Provider Interventions to Reduce Co-Prescribing of Opioids and Benzodiazepines among a Medicare Population

Pharmacy, 2020
Co-prescribing of opioids and benzodiazepines can lead to overdoses and mortality. This retrospective study analyzed prescription claims data collected in 2016.
Jennifer M. Bingham, Ann M. Taylor, Kevin P. Boesen, David R. Axon   +3 more
doaj   +1 more source

Fully Automated Synthesis of Novel TSPO PET Imaging Ligand [¹⁸F]Fluoroethyltemazepam

Molecules, 2021
Introduction: Benzodiazepines, including temazepam are described as TSPO antagonists. In fact, TSPO was initially described as a peripheral benzodiazepine receptor (PBR) with a secondary binding site for diazepam.
Dario Fiorenza, Emanuele Nicolai, Carlo Cavaliere, Ferdinando Fiorino, Giovanna Esposito, Marco Salvatore   +5 more
doaj   +1 more source

Designer Benzodiazepines: A Review of Toxicology and Public Health Risks

Pharmaceuticals, 2021
The rising use of designer benzodiazepines (DBZD) is a cat-and-mouse game between organized crime and law enforcement. Non-prohibited benzodiazepines are introduced onto the global drug market and scheduled as rapidly as possible by international ...
Pietro Brunetti, Raffaele Giorgetti, Adriano Tagliabracci, Marilyn A. Huestis, Francesco Paolo Busardò   +4 more
doaj   +1 more source

Benzodiazepine use and risk of Alzheimer’s disease: case-control study

British medical journal, 2014
Objectives To investigate the relation between the risk of Alzheimer’s disease and exposure to benzodiazepines started at least five years before, considering both the dose-response relation and prodromes (anxiety, depression, insomnia) possibly linked ...
Sophie Billioti de Gage, Y. Moride, T. Ducruet, T. Kurth, H. Verdoux, M. Tournier, A. Pariente, B. Bégaud   +7 more
semanticscholar   +1 more source