Results 81 to 90 of about 156,110 (291)

Comparisons Between Successful Versus Unsuccessful Switches From Benzodiazepines or Zolpidem (Z-Drug) to Controlled-Release Melatonin in Patients With Major Depressive Disorder and Insomnia

Frontiers in Psychiatry, 2020
ObjectivesChronic use of benzodiazepines and zolpidem (BDZ/Z-drugs) leads to dependency, cognitive impairment, and falls. Although controlled-release melatonin (Melatonin CR) may be an alternative, a switch in clinical settings has proven difficult.
Ji Hyun An, Mi Jin Park, Maurizio Fava, David Mischoulon, Hyewon Kim, Jihoon Jang, Jin Pyo Hong, Jun Sang Park, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon, Hong Jin Jeon   +11 more
doaj   +1 more source

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Addressing the Issue of Chronic, Inappropriate Benzodiazepine Use: How Can Pharmacists Play a Role?

Pharmacy, 2013
Prescribing guidelines do not recommend the long-term use of benzodiazepines since their effectiveness with chronic use is out-weighed by risks including dependence, memory and cognitive impairment, hip fractures and traffic accidents.
Helen C. Gallagher
doaj   +1 more source

Patient anxiety and modern elective surgery: a literature review [PDF]

, 2003
Medical advances have led to a considerable rise in the level of elective surgery undertaken as day-case surgery and with minimal hospital stay. However, amid such advances, preoperative psychological care has remained relatively static.
Mitchell, MJ
core   +1 more source

The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Polypharmacy is increasingly recognized as a relevant issue in diabetes care, but its prevalence and clinical relevance in individuals with type 1 diabetes remain underexplored. This study aimed to determine the prevalence of polypharmacy and to identify associated clinical and psychological factors. Participants were recruited from a tertiary diabetes
Namam Ali, Stephan van Erp, Cornelis Kramers, Cornelis J. Tack, Bastiaan E. de Galan   +4 more
wiley   +1 more source

Former heroin-dependent alcohol use disorder patients. prevalence, addiction history and clinical features [PDF]

, 2015
Aims: To examine the prevalence of former heroin dependence (FHA) in Alcohol Use Disorder (AUD) patients; to compare the clinical characteristics of FHA-AUD patients versus AUD patients without any past use of heroin at alcohol treatment entry; to ...
Ceccanti, Mauro, Maremmani, Angelo Giovanni Icro, Maremmani, Icro, Pacini, Matteo   +3 more
core   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, EarlyView.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Benzodiazepine agonist treatment for patients with benzodiazepine dependence undergoing opioid agonist treatment: a study protocol for the randomized controlled trial BMX-BAR

Trials
Background There is a lack of knowledge on effective treatment methods for comorbid benzodiazepine dependence in populations undergoing opioid agonist treatment (OAT).
Fatemeh Chalabianloo, Lars Thore Fadnes, Jörg Assmus, Jon Mordal, Kristin K. Solli, Kjetil S. Dale, Christina D. Andersen, Silvia Zavenova, Beathe H. Rønning, Andreas W. Blomkvist, Martin Ryssdal, Wasifa S. J. Butt, Anne Marciuch, Anne G. Ørmen, Christian Ohldieck, Else-Marie Løberg, Kjell Arne Johansson, for the BMX-BAR and NORCATS study group   +17 more
doaj   +1 more source

Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB‐5′Br‐PINACA, in Seized Herbal Materials

Drug Testing and Analysis, EarlyView.
MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi, Lucas André Zeoly, Rafael Lanaro, Ingrid Simões Oliveira, Mariana Cepollaro Diana, Mauricio Yonamine, Jose Luiz Costa   +6 more
wiley   +1 more source