Results 101 to 110 of about 132,663 (305)

Benzodiazepines [PDF]

open access: yesJournal of Pain and Symptom Management, 2014
Paul, Howard   +4 more
openaire   +2 more sources

Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real‐world clinical practice

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective Patients with drug‐resistant epilepsy (DRE) typically take multiple anti‐seizure medications (ASMs) and are at risk of treatment‐related adverse events (AEs). This study assessed the impact of cenobamate monotherapy or dual therapy in patients with drug‐resistant epilepsy.
Álvaro Sánchez‐Guijo Benavente   +13 more
wiley   +1 more source

Discouraging Use of Benzodiazepines for Anxiety and Insomnia [PDF]

open access: yes, 2018
Benzodiazepines are commonly prescribed for anxiety and insomnia because patients respond quickly to them. Although they are meant to be short-term solutions, patients often use them for more than ten years.
Tsao, Jackie
core   +1 more source

Self‐limited neonatal epilepsy with 2q24.3 duplications: Case series and literature review

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective To clarify the phenotypic spectrum associated with duplications involving the 2q24.3 region, which includes a cluster of genes encoding sodium channel subunits (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A). Methods We reviewed our research database for patients with epilepsy and 2q24.3 duplication and performed thorough phenotyping.
Saba Al Rawahi, Kenneth A. Myers
wiley   +1 more source

Symptom-Triggered Alcohol Detoxification Compared to Fixed-Dose Regimen of Benzodiazepines: A Retrospective Case–Control Study

open access: yesBrain Sciences
Background: Alcohol withdrawal syndrome is a common clinical challenge that may lead to significant complications if not properly managed. Symptom-triggered therapy (STT) represents a promising alternative to fixed-dose regimens (FDRs) providing ...
Laurent Becciolini   +5 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of (4Z)-1-butyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2018
The asymmetric unit of the title compound, C16H20N2O2, consists of two independent molecules differing slightly in the conformations of the seven-membered rings and the butyl substituents, where the benzene rings are oriented at a dihedral angle of 34.56 
Karim Chkirate   +5 more
doaj   +1 more source

Patient anxiety and modern elective surgery: a literature review [PDF]

open access: yes, 2003
Medical advances have led to a considerable rise in the level of elective surgery undertaken as day-case surgery and with minimal hospital stay. However, amid such advances, preoperative psychological care has remained relatively static.
Mitchell, MJ
core   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

open access: yesEpilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin   +7 more
wiley   +1 more source

(4E)-1-Decyl-4-(2-oxopropylidene)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

open access: yesIUCrData, 2016
The title compound, C22H32N2O2, forms bilayers with the n-decyl chains in extended conformation oriented towards the interior of the bilayer structure. Weak C—H...O interactions help to stabilize the exterior surfaces.
Jihad Sebhaoui   +4 more
doaj   +1 more source

Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study [PDF]

open access: yes, 2000
Background. Hip fracture is common in the elderly. Previous studies suggest that psychiatric illness is common and predicts poor outcome, but have methodological weaknesses. Further studies are required to address this important issue. Methods.
Holmes, J., House, A.
core   +1 more source

Home - About - Disclaimer - Privacy