Results 111 to 120 of about 79,764 (263)

The psychoactive effects of repeated ketamine infusions and their mechanistic role in the treatment of alcohol use disorder: Secondary analysis of a randomised controlled trial

Addiction, EarlyView.
Abstract Background and aims Ketamine assisted psychotherapy is a promising new treatment for alcohol use disorder (AUD). The psychoactive effects of repeated intravenous (IV) ketamine infusions in people with AUD and their mechanistic role in treating AUD are largely unknown.
Cassie Bloy, Ananya Sarma, Bethan Marsh, Lorna Hardy, Meryem Grabski, Merve Mollaahmetoglu, Joshua Shotton, Shamhethan Bhaskaran, Anne Lingford‐Hughes, H. Val Curran, Celia Morgan, Will Lawn   +11 more
wiley   +1 more source

Healthcare utilization and mortality after overdose prevention site closure: A linked cohort analysis using segmented difference‐in‐differences time series

Addiction, EarlyView.
Abstract Background and aims Evidence regarding the impacts of supervised drug consumption services (SDC) remains mixed, and few evaluations have used individual‐level, linkable health data to examine service withdrawal. In September 2024, the Red Deer overdose prevention site (OPS) in Alberta, Canada, was scheduled for closure, with operations ceasing
Nathaniel Day, Kym Kaufmann, Daniel John Alexander Devoe, Vanja Grubac, Alessia DiMarzo, Haisa Osmanli, Vanessa Norton, Shelly Vik, Nickie Mathew, Robert Lawrence Tanguay, Anees Bahji   +10 more
wiley   +1 more source

Editorial Note: Long-term consequences of benzodiazepine-induced neurological dysfunction: A survey. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

A call for action: Closing the evidence gap in management of stimulant‐induced psychosis

Addiction, EarlyView.
Abstract Background Stimulant‐induced psychosis (StIP) is emerging as one of most pressing health challenges. Over the past two decades, stimulant‐related harms and psychiatric care demands have risen sharply. Individuals with StIP often present with severe agitation and high suicide risk, and up to half progress to chronic psychotic illness within two
Anne Bouthillier, Heidar Sharafi, Adam Bisaga, Didier Jutras‐Aswad   +3 more
wiley   +1 more source

Pharmacological principles for safe benzodiazepine and Z-drug dose reduction. [PDF]

Psychol Med
Horowitz M, Lamberson N, Brandt J, Framer A, Shapiro B, Sørensen A, Cadogan C, Ritvo A, Taylor D.   +8 more
europepmc   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Benzodiazepine receptor agonist deprescribing principles for long-term use and dependence: modified Delphi recommendations from a multi-disciplinary expert panel. [PDF]

Ther Adv Psychopharmacol
Brandt J, Lamberson N, Bressi J, Ritvo A, Curle J, Witt-Doerring J, DeWert M, Wright S, Horowitz M.   +8 more
europepmc   +1 more source

The Opioid Safety Toolkit: An interactive prescription opioid safety toolkit to increase opioid safety literacy and behaviours among people prescribed opioids for pain—a randomised controlled trial

Addiction, EarlyView.
Abstract Background and aims Prescription opioid‐related harm remains a significant public health concern. This study aimed to evaluate the efficacy of the Opioid Safety Toolkit, a co‐designed, interactive online resource, in increasing naloxone uptake and healthcare provider discussions among adults prescribed opioids for pain.
Suzanne Nielsen, Frederick Fox, Tina Lam, Alex Waddell, Monica Jung, Bosco Rowland, Jessica Watterson, Dhruv Basur, Chris Prawira, Joshua Paolo Seguin, Patrick Olivier, Jarrod McMaugh, Paul Dietze, Louisa Picco   +13 more
wiley   +1 more source

Benzodiazepine exposure during early pregnancy and risk of miscarriage: dose-response, half-life classification, and individual agents. [PDF]

Arch Womens Ment Health
Ishikawa T, Sakai T, Iwama N, Obara R, Morishita K, Adomi M, Kunitoki T, Noda A, Ishikuro M, Kikuchi S, Kobayashi N, Tomita H, Saito M, Nishigori H, Kuriyama S, Mano N, Obara T.   +16 more
europepmc   +1 more source

Drug sellers' use of a drug checking service amid the overdose crisis in British Columbia, Canada

Addiction, EarlyView.
Abstract Aims This study examined the use of a drug checking service by drug sellers in British Columbia, Canada, to assess motivations for service use and substances intended for distribution, focusing on risks associated with an unstable illicit drug market.
Pablo Gonzalez‐Nieto, Bruce Wallace, Collin Kielty, Irene Shkolnikov, Ava Margolese, Jaime Arredondo Sanchez Lira, Chris Gill, Dennis Hore   +7 more
wiley   +1 more source