Results 31 to 40 of about 1,553 (193)

Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines [PDF]

, 2014
The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing ...
Antonow, Broggini, Christopher Chambers, Faisal Jamshaid, Karl Hemming, Mitra, Patel, Paul O'Gorman, Rahman, Thurston   +9 more
core   +2 more sources

A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation [PDF]

, 2004
This paper describes the use of multivariate statistical procedure PCA as a tool to explore the inhibitory activity of classes of NNRTIs against HIV-1 viruses (wild type and more frequent mutants, Y181C, V106A, K103N, L100I) and against RT enzyme.
Arranz, Bacheler, Balzarini, Buckheit, Campiani, Carbo, Clercq, Clercq, Corbett, Hajos, Huberty, Manly, Petropoulos, Silvestri, Tramontano, Xu, Zembower   +16 more
core   +1 more source

APPLICATION OF THE MACHINE AND DEEP LEARNING METHODS FOR THE CLASSIFICATION OF CANNABINOID- AND CATHINONE-DERIVED COMPOUNDS [PDF]

, 2020
Objective: New psychoactive substances (NPS) have been rapidly developed to avoid legal entanglement. In 2013–2018, the number of cathinonederivedcompounds increased from 30 to 89.
ARYATI, WIDYA DWI, SUSANTO, GERRY MAY, WINARKO, MUHAMMAD SIDDIQ, YANUAR, ARRY   +3 more
core   +3 more sources

Thiazide‐Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone

The Journal of Clinical Hypertension, Volume 27, Issue 5, May 2025.
ABSTRACT Hyponatremia is a crucial complication of therapy with thiazide diuretics. This study compares the epidemiological and biochemical profiles and hospital course of patients using hydrochlorothiazide (HCTZ), indapamide (INDA), and chlorthalidone (CTD) admitted with thiazide‐associated hyponatremia (TAH).
Josef Klhůfek, Martin Vodička, Petr Ponížil, Ilja Ryšavý, Petr Fojtík, Vladimír Kojecký, Tomáš Šálek   +6 more
wiley   +1 more source

Managing Hypoglycaemia in Patients With Insulinoma—A Tertiary Centre Experience and Review of the Literature

Clinical Endocrinology, Volume 102, Issue 3, Page 344-354, March 2025.
ABSTRACT The management of hypoglycaemia is pivotal in the care of patients with insulinoma. Blood glucose monitoring and regulation needs careful attention pre‐ and peri‐operatively for patients undergoing surgical resection and as part of the long‐term management for patients with inoperable or metastatic disease.
Sophie Howarth, Tak‐Wai Ho, James Wimbury, Ruth Casey   +3 more
wiley   +1 more source

Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative

British Journal of Pharmacology, Volume 176, Issue 20, Page 3924-3938, October 2019., 2019
Background and Purpose The TRPC1, TRPC4, and TRPC5 proteins form homotetrameric or heterotetrameric, calcium‐permeable cation channels that are involved in various disease states. Recent research has yielded specific and potent xanthine‐based TRPC1/4/5 inhibitors.
Aisling Minard, Claudia C. Bauer, Eulashini Chuntharpursat‐Bon, Isabelle B. Pickles, David J. Wright, Melanie J. Ludlow, Matthew P. Burnham, Stuart L. Warriner, David J. Beech, Katsuhiko Muraki, Robin S. Bon   +10 more
wiley   +1 more source

Development and Validation of RP‐HPLC Method for the Determination of Hydrochlorothiazide in Bulk Drug and Pharmaceutical Dosage Form

Chromatography Research International, Volume 2016, Issue 1, 2016., 2016
An HPLC‐PDA method was developed and validated for the determination of hydrochlorothiazide in bulk and pharmaceutical formulation. The method was optimized selecting chromatographic conditions of 50 : 50 acetonitrile : water, Inertsil® column (ODS‐3 250 mm × 4.6 mm 5 μm), 20 μL injection volume, flow rate of 1 mL/min at ambient temperature (30°C), and
Nidhal S. Mohammed, Ahmed J. Mohammed, Susana Casal   +2 more
wiley   +1 more source

Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis

Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.
Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley   +1 more source

2-[7-Chloro-1,1-dioxo-2-(2,4,5-trifluoro­benz­yl)-3,4-dihydro-2H-1,2,4-benzothia­diazin-4-yl]acetic acid [PDF]

, 2012
In the mol­ecule of the title compound, C16H12ClF3N2O4S, the thia­diazine ring adopts a half-chair conformation. The dihedral angle between the benzene ring of the benzothia­diazine ring system and trifluoro­phenyl group is 15.02 (7)°.
Braghiroli, Buckheit, Changjin Zhu, Chen, Francotte, Longman, Phillips, Pirotte, Sheldrick, Yamada, Yanchun Yang, Yuhua Guo   +11 more
core   +3 more sources

Effects of thiazides and new findings on kidney stones and dysglycemic side effects

Acta Physiologica, Volume 240, Issue 7, July 2024.
Abstract Thiazide and thiazide‐like diuretics (thiazides) belong to the most frequently prescribed drugs worldwide. By virtue of their natriuretic and vasodilating properties, thiazides effectively lower blood pressure and prevent adverse cardiovascular outcomes.
Matteo Bargagli, Manuel A. Anderegg, Daniel G. Fuster   +2 more
wiley   +1 more source