Results 11 to 20 of about 6,067 (184)

Molecular Docking and Dynamics of SARS-CoV-2 Programmed Ribosomal Frameshifting RNA and Ligands for RNA-Targeting Alkaloids Prospecting

open access: yesHayati Journal of Biosciences, 2023
RNA-ligand docking is a part of computational biology, which is currently lowly recognized compared to the protein-ligand docking procedure commonly applied for drug discovery.
Adhityo Wicaksono   +1 more
doaj   +1 more source

Alkaloid Biosynthesis in the Early Stages of the Germination of Argemone mexicana L. (Papaveraceae)

open access: yesPlants, 2021
The synthesis of the benzylisoquinoline alkaloids, sanguinarine and berberine, was monitored in Argemone mexicana L. (Papaveracea) throughout the early stages of its hypocotyl and seedling development.
Jorge Xool-Tamayo   +4 more
doaj   +1 more source

Toxicological Effects of Berberine and Sanguinarine

open access: yesFrontiers in Molecular Biosciences, 2018
Berberine and Sanguinarine alkaloids belong to a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral or weakly acidic properties. Alkaloids are produced by
Nitika Singh, Bechan Sharma
doaj   +1 more source

Biological Activity of Berberine—A Summary Update

open access: yesToxins, 2020
Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical ...
Anna Och   +2 more
doaj   +1 more source

Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

open access: yesFrontiers in Aging Neuroscience, 2023
There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the link between the two is often referred to as type 3 diabetes mellitus (T3DM).
Juan Huang   +6 more
doaj   +1 more source

Anticancer Potential of Natural Isoquinoline Alkaloid Berberine

open access: yesJournal of Exploratory Research in Pharmacology, 2021
Despite the availability of several therapeutic strategies and many drugs, the ability to cure most cancers remains a challenge. Natural products have been used for the treatment of numerous diseases, including cancer. The present review delineates various preclinical studies performed in vitro and in vivo that explore the anticancer potential of ...
openaire   +1 more source

Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

open access: yesBMC Pharmacology and Toxicology, 2022
Background Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20–42 days).
Yan-Yu Zhang   +3 more
doaj   +1 more source

Berberine, an Epiphany Against Cancer

open access: yesMolecules, 2014
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism.
Luis Miguel Guamán Ortiz   +3 more
doaj   +1 more source

Modulatory Effect of Chelidonium majus Extract and Its Alkaloids on LPS-Stimulated Cytokine Secretion in Human Neutrophils

open access: yesMolecules, 2020
Due to certain differences in terms of molecular structure, isoquinoline alkaloids from Chelidonium majus engage in various biological activities.
Sylwia Zielińska   +7 more
doaj   +1 more source

Influence of Postharvest Drying Temperatures on Alkaloid Levels in Goldenseal (Hydrastis canadensis L.)

open access: yesHortScience, 2021
Goldenseal (Hydrastis canadensis L.) is a medicinal forest herb native to Appalachia. Its roots and rhizomes are used as an antimicrobial and for the treatment of intestinal ailments.
Grady H. Zuiderveen   +2 more
doaj   +1 more source

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