Natural Alkaloids as Antimicrobial Agents: Mechanisms, Potentials and Challenges. [PDF]
MoleculesAntimicrobial resistance (AMR) poses a significant global health threat, with multidrug-resistant pathogens undermining the effectiveness of conventional antibiotics. Natural alkaloids, a diverse group of nitrogen-containing compounds mainly derived from
Zhang XZ +6 more
europepmc +2 more sources
Natural Product Communications, 2023 Introduction Berberis vulgaris extract is a well-known herbal remedy for treating numerous conditions including coronavirus disease 2019 (COVID-19). The HAB4a method of preparing the extract is a common method used in clinical practice and a further aim ...
Samantha Gildenhuys +4 more
doaj +1 more source
Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus
Frontiers in Aging Neuroscience, 2023 There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM), and the link between the two is often referred to as type 3 diabetes mellitus (T3DM).
Juan Huang +6 more
doaj +1 more source
Berberine and Palmatine Distribution Across Plant Organs in <i>Berberis darwinii</i>: Basis for Selecting Superior-Producing Accessions. [PDF]
MoleculesBerberis darwinii, known for its bioactive alkaloids like berberine and palmatine, has gained attention for its medicinal properties. However, comprehensive studies on the specific bioactive molecules of Michay are lacking, as previous research has ...
Chacón-Fuentes M +4 more
europepmc +2 more sources
Berberine, an Epiphany Against Cancer
Molecules, 2014 Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism.
Luis Miguel Guamán Ortiz +3 more
doaj +1 more source
Molecules, 2020 Due to certain differences in terms of molecular structure, isoquinoline alkaloids from Chelidonium majus engage in various biological activities.
Sylwia Zielińska +7 more
doaj +1 more source
BMC Pharmacology and Toxicology, 2022 Background Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20–42 days).
Yan-Yu Zhang +3 more
doaj +1 more source
Screening of isoquinoline alkaloids for potent lipid metabolism modulation with Caenorhabditis elegans. [PDF]
, 2013 Metabolic syndrome and related disorders are increasingly prevalent in contemporary society, and thus pose the need for potent agents to control lipid accumulation in the body.
Chow, Yit-Lai, Sato, Fumihiko
core +1 more source
S-adenosyl-l-methionine: (S) -7,8,13, 14-tetrahydroberberine--n-methyltransferase, a branch point enzyme in the biosynthesis of benzophenanthridine and protopine alkaloids. [PDF]
, 1986 The enzyme which transfers the CH3-group of S-adenosylmethionine to the nitrogen atom of (S)-tetrahydroberberine and (S)-stylopine is found to occur in a number of plant cell cultures originating from species containing alkaloids; it is located at an ...
Amann +8 more
core +1 more source
Polymorphic Nucleic Acid Binding of Bioactive Isoquinoline Alkaloids and Their Role in Cancer
Journal of Nucleic Acids, 2010 Bioactive alkaloids occupy an important position in applied chemistry and play an indispensable role in medicinal chemistry. Amongst them, isoquinoline alkaloids like berberine, palmatine and coralyne of protoberberine group, sanguinarine of the ...
Motilal Maiti, Gopinatha Suresh Kumar
doaj +1 more source