Results 11 to 20 of about 81,348 (224)

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Nature Communications
Protoberberine alkaloids and benzophenanthridine alkaloids (BZDAs) are subgroups of benzylisoquinoline alkaloids (BIAs), which represent a diverse class of plant-specialized natural metabolites with many pharmacological properties. Microbial biosynthesis
Xiang Jiao, Xiaozhi Fu, Qishuang Li, Junling Bu, Xiuyu Liu, Otto Savolainen, Luqi Huang, Juan Guo, Jens Nielsen, Yun Chen   +9 more
doaj   +2 more sources

Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid [PDF]

, 2013
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were ...
Shah, Syed Qaisar, Gray, Alexander, Clements, Carol, Igoli, John, Ali, Saqib, Almazeb, Muhammad, Khan, M Rafiullah, Ferro, Valerie, Rashid, Mamoon-Ur, Semaan, Dima   +9 more
core   +4 more sources

Radical Approaches to Alangium and Mitragyna Alkaloids [PDF]

, 2010
The work presented in this thesis has focused on the development of novel and concise syntheses of Alangium and Mitragyna alkaloids, and especial approaches towards (±)-protoemetinol (a), which is a key precursor of a range of Alangium alkaloids such as ...
Palframan, M J
core   +7 more sources

In Vitro Analyses of the Multifocal Effects of Natural Alkaloids Berberine, Matrine, and Tabersonine against the O’nyong-nyong Arthritogenic Alphavirus Infection and Inflammation

Pharmaceuticals, 2023
O’nyong-nyong virus (ONNV) is a member of the reemerging arthritogenic alphaviruses that cause chronic debilitating polyarthralgia and/or polyarthritis via their tropism for the musculoskeletal system.
Anne-Laure Sandenon Seteyen, Pascale Guiraud, Philippe Gasque, Emmanuelle Girard-Valenciennes, Jimmy Sélambarom   +4 more
doaj   +1 more source

Unified Synthesis of Polycyclic Alkaloids via Complementary Carbonyl Activation [PDF]

, 2021
A complementary dual carbonyl activation strategy for thesynthesis of polycyclic alkaloids has been developed. Successful applications include the synthesis of tetracyclic alkaloids harmalanine, harmalacinine, pentacyclic indoloquinolizidine alkaloid ...
Guoli, He, Benjamin, List, Mathias, Christmann   +2 more
core   +1 more source

Molecular Docking and Dynamics of SARS-CoV-2 Programmed Ribosomal Frameshifting RNA and Ligands for RNA-Targeting Alkaloids Prospecting

Hayati Journal of Biosciences, 2023
RNA-ligand docking is a part of computational biology, which is currently lowly recognized compared to the protein-ligand docking procedure commonly applied for drug discovery.
Adhityo Wicaksono, Arli Aditya Parikesit   +1 more
doaj   +1 more source

Alkaloid Biosynthesis in the Early Stages of the Germination of Argemone mexicana L. (Papaveraceae)

Plants, 2021
The synthesis of the benzylisoquinoline alkaloids, sanguinarine and berberine, was monitored in Argemone mexicana L. (Papaveracea) throughout the early stages of its hypocotyl and seedling development.
Jorge Xool-Tamayo, Yahaira Tamayo-Ordoñez, Miriam Monforte-González, José Armando Muñoz-Sánchez, Felipe Vázquez-Flota   +4 more
doaj   +1 more source

Biological Activity of Berberine—A Summary Update

Toxins, 2020
Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical ...
Anna Och, Rafał Podgórski, Renata Nowak   +2 more
doaj   +1 more source

Structure-activity relationships of synthetic analogs of jasmonic acid and coronatine on induction of benzo[c]phenanthridine alkaloid accumulation in Eschscholzia californica cell cultures [PDF]

, 2000
A facile test system based on the accumulation of benzo[c]phenanthridine alkaloids in Eschscholzia californica cell suspension culture (an indicator of defense gene activation) has been used to analyze a series of synthetic compounds for elicitor-like ...
Blechert, S., Kutchan, T. M., Schrader, T. von, Haider, G., Füßlein, M.   +4 more
core   +1 more source

An Analysis in Identifying the Mechanism of Action of the Alkaloids Found in on the Treatment and Prevention of SARS-CoV-2

Natural Product Communications, 2023
Introduction Berberis vulgaris extract is a well-known herbal remedy for treating numerous conditions including coronavirus disease 2019 (COVID-19). The HAB4a method of preparing the extract is a common method used in clinical practice and a further aim ...
Samantha Gildenhuys, Paul Anton Steenkamp, Lucas Sekele, Salerwe Mosebi, Chad Clifton James   +4 more
doaj   +1 more source