Results 51 to 60 of about 6,067 (184)

Berberine suppresses migration of MCF-7 breast cancer cells through down-regulation of chemokine receptors [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis ...
Naghmeh Ahmadiankia, Hamid Kalalian Moghaddam, Mohammad Amir Mishan, Ahmad Reza Bahrami, Hojjat Naderi-Meshkin, Hamid Reza Bidkhori, Maryam Moghaddam, Seyed Jamal Aldin Mirfeyzi   +7 more
doaj  

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

Biodegradable Sodium Alginate Films Incorporated With Jateorhiza palmata (Lam.) Miers Extract for Active Food Packaging

Packaging Technology and Science, Volume 39, Issue 4, Page 367-382, April 2026.
Development of biodegradable sodium alginate films incorporated with J. palmata root extracts showing enhanced antioxidant and functional properties for active food packaging applications. ABSTRACT Biodegradable packaging helps reduce environmental impact by decomposing naturally and preventing plastic accumulation in ecosystems.
Carlos Augusto Badillo Almeira, Suiane Savazzi, Raul Remor Dalsasso, Alcilene Rodrigues Monteiro, Alessandro de Oliveira Rios   +4 more
wiley   +1 more source

Aggregation of DNA Enhanced by the Protoberberine Alkaloids, Coralyne and Berberine.

Chemical and Pharmaceutical Bulletin, 1994
The aggregation of DNA caused by coralyne was studied by spectroscopic, viscosity and electric birefringence measurements. Aggregation was markedly enhanced over a narrow range of coralyne to DNA phosphate ratio and then followed by precipitation.
Z, Taira, M, Matsumoto, S, Ishida, T, Ichikawa, Y, Sakiya   +4 more
openaire   +3 more sources

Auxin‐Induced Nicotine Inhibition Is Mediated by NaARF5 Through the Suppression of NaERF1‐Like Expression and Interaction With NaERF1‐Like in Nicotiana attenuata

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2642-2656, April 2026.
ABSTRACT Nicotine is the most abundant alkaloid produced by Nicotiana species against insect herbivores. Although it has been known for decades that auxin can strongly inhibit nicotine biosynthesis, the underlying mechanisms have remained unclear.
Miyun Yang, Ahui Tong, Lei Wang, Jinsong Wu   +3 more
wiley   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Inhibition of In-vitro Lymphocyte Transformation by the Isoquinoline Alkaloid Berberine

Journal of Pharmacy and Pharmacology, 1995
Abstract Berberine is an isoquinoline alkaloid with multiple pharmacological actions, including an anti-inflammatory activity. The effects of berberine on in-vitro cellular proliferation of human peripheral lymphocytes stimulated with phytohaemagglutinin, concanavalin A and pokeweed mitogen were studied.
K, Ckless, J L, Schlottfeldt, M, Pasqual, P, Moyna, J A, Henriques, M, Wajner   +5 more
openaire   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High‐Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry

Biomedical Chromatography, Volume 40, Issue 3, March 2026.
ABSTRACT Veratrum L. species have been used in traditional medicine for centuries due to their bioactive properties, yet they also contain toxic steroid alkaloids that pose potential health risks when present in herbal preparations. Reliable analytical approaches are therefore essential to ensure product safety, protect consumer health and assess ...
Julia Siegle, Jörg Pietsch
wiley   +1 more source

Argemone ochroleuca: (PAPAVERACEAE), ALKALOID POTENTIAL SOURCE FOR AGRICULTURAL AND MEDICINAL USES

Tropical and Subtropical Agroecosystems, 2020
Background. The genus Argemone contains 24 species, A. ochorleuca is present in national territory and is used in agriculture and traditional medical treatments for various conditions. Results. A.
Jesús Hernández-Ruiz, Julio Bernal, Jorge Eric Ruiz-Nieto, Jaquelina Gonzales-Castañeda, Ana Isabel Mireles-Arriaga   +4 more
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