Viral Hijacking of BET Proteins [PDF]
Viruses, 2022 Proteins of the bromodomain and exterminal domain (BET) family mediate critical host functions such as cell proliferation, transcriptional regulation, and the innate immune response, which makes them preferred targets for viruses.
Irene P. Chen, Melanie Ott
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Role of BET Proteins in Inflammation and CNS Diseases [PDF]
Frontiers in Molecular Biosciences, 2021 Bromodomain and extra-terminal domain (BET) proteins consist of four mammalian members (BRD2, BRD3, BRD4, and BRDT), which play a pivotal role in the transcriptional regulation of the inflammatory response. Dysregulated inflammation is a key pathological
Lei Liu +2 more
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Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer [PDF]
Cells, 2023 Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of dense stroma that is enriched in hyaluronan (HA), with increased HA levels associated with more aggressive disease.
Krishan Kumar +6 more
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Dysregulation of BET proteins in levodopa-induced dyskinesia [PDF]
Neurobiology of Disease, 2017 Levodopa (L-DOPA) remains the most effective pharmacological treatment for Parkinson Disease (PD) but its use is limited by the development of debilitating drug-related side effects, particularly L-DOPA induced dyskinesia (LID).
David A. Figge, David G. Standaert
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Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy [PDF]
Signal Transduction and Targeted Therapy, 2023 BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment.
Zhi-Qiang Wang +7 more
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The Functions of BET Proteins in Gene Transcription of Biology and Diseases [PDF]
Frontiers in Molecular Biosciences, 2021 The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology.
Ka Lung Cheung +2 more
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A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-driven MB.
Matthew J. Kling +9 more
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BET Proteins Regulate Expression of Osr1 in Early Kidney Development [PDF]
Biomedicines, 2021 In utero renal development is subject to maternal metabolic and environmental influences affecting long-term renal function and the risk of developing chronic kidney failure and cardiovascular disease.
Janina Schreiber +6 more
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Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation [PDF]
Epigenetics & Chromatin, 2020 Background Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer.
Archit Trivedi +9 more
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The Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins Protects Against Microglia-Mediated Neuronal Loss In Vitro [PDF]
BiomoleculesNeuroinflammation is a key feature of all neurodegenerative disorders, including Alzheimer’s disease, and is tightly regulated by epigenetic mechanisms.
Marta Matuszewska +4 more
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