BET bromodomain proteins regulate enhancer function during adipogenesis [PDF]
Proceedings of the National Academy of Sciences, 2018 Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression program.
Jonathan D. Brown +13 more
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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]
, 2013 Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina +13 more
core +4 more sources
Functions of BET proteins in erythroid gene expression [PDF]
Blood, 2015 Key Points BETs promote GATA1 chromatin occupancy and subsequently activate transcription; they are generally not required for repression. BRD2 and BRD4 are essential for full GATA1 activity whereas BRD3 function overlaps with BRD2.
Aaron J, Stonestrom +10 more
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Epigenetics in Oncohematology: Brief Review
Клиническая онкогематология, 2015 Objective. To discuss historical aspects of epigenetics as an independent branch of biology, as well as to describe post-translational modifications of DNA and histones (PTMs) as epigenetic events. Methods.
Anton Dmitrievich Shirin +2 more
doaj +1 more source
Targeting BET bromodomain proteins in solid tumors
Oncotarget, 2016 There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins and cancer progression. BET inhibitors were initially shown to have efficacy in hematologic malignancies; however, a number of studies have now shown that BET inhibitors can also block progression
Sahai, Vaibhav +4 more
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Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis [PDF]
, 2016 International audienceHistone modifications are important for maintaining the transcription program. BET proteins, an important class of " histone reading proteins " , have recently been described as essential in bone biology.
Asangani +47 more
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Effect of the Strawberry Genotype, Cultivation and Processing on the Fra a 1 Allergen Content [PDF]
, 2018 Birch pollen allergic patients show cross-reactivity to vegetables and fruits, including strawberries (Fragaria × ananassa). The objective of this study was to quantify the level of the Fra a 1 protein, a Bet v 1-homologous protein in strawberry fruits
Kock, V. +4 more
core +2 more sources
Effect of bet missense mutations on bromodomain function, inhibitor binding and stability [PDF]
, 2016 Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a ...
Alessandra, Pasquo +7 more
core +2 more sources
BET‐ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors [PDF]
BioEssays, 2018 BET proteins such as Brd3 and Brd4 are chromatin‐associated factors, which control gene expression programs that promote inflammation and cancer. The Nrf2 transcription factor is a master regulator of genes that protect the organism against xenobiotic attack and oxidative stress.
Nirmalya, Chatterjee, Dirk, Bohmann
openaire +2 more sources
Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]
, 2008 Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht +6 more
core +1 more source