P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts [PDF]
Cancer Cell International, 2005 Background This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation.
Kolman Kevin +4 more
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β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. [PDF]
PLoS ONE, 2011 Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression.
Tobias Sinnberg +7 more
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A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma [PDF]
Frontiers in Endocrinology, 2023 BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC).
Enzo Lalli, Enzo Lalli, Enzo Lalli
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NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. [PDF]
PLoS ONE, 2009 The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin.
Ali M Riazi +7 more
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GSK3beta is involved in JNK2-mediated beta-catenin inhibition. [PDF]
PLoS ONE, 2009 We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation.
Dong Hu +4 more
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CK1epsilon is required for breast cancers dependent on beta-catenin activity. [PDF]
PLoS ONE, 2010 Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date.To uncover genetic dependencies in
So Young Kim +13 more
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In melanoma, beta-catenin is a suppressor of invasion [PDF]
Oncogene, 2011 Cell-type-specific signalling determines cell fate under physiological conditions, but it is increasingly apparent that also in cancer development the impact of any given oncogenic pathway on the individual cancer pathology is dependent on cell-lineage-specific molecular traits.
Arozarena, I +5 more
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Nuclear beta-catenin in mesenchymal tumors [PDF]
Modern Pathology, 2004 Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony Ng +8 more
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Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML [PDF]
Mediterranean Journal of Hematology and Infectious DiseasesBackground: Acute myeloid leukaemia(AML) is a disease of the haematopoietic stem cells. Beta-catenin, a key element of the Wnt signalling, which is particularly active in various cancers.
Buket Altinok Gunes +10 more
doaj +2 more sources
Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex [PDF]
The EMBO Journal, 2001 The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats. We have determined the crystal structure of a 15 amino acid beta-catenin binding repeat from APC bound to the ...
K.E. Spink
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