Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer [PDF]
Cell Death and Differentiation, 2022 The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang, Jiping Zeng, Lixin Zheng
exaly +3 more sources
Brain Beta-Catenin Signalling During Stress and Depression
Neurosignals, 2018 Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway.
Chuin Hau Teo +2 more
doaj +2 more sources
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. [PDF]
Genes & Development, 1996 The serine/threonine kinase Xgsk-3 and the intracellular protein beta-catenin are necessary for the establishment of the dorsal-ventral axis in Xenopus.
C. Yost +5 more
semanticscholar +2 more sources
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. [PDF]
PLoS ONE, 2009 The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin.
Ali M Riazi +7 more
doaj +10 more sources
A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma [PDF]
Frontiers in Endocrinology, 2023 BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC).
Enzo Lalli, Enzo Lalli, Enzo Lalli
doaj +2 more sources
Frontiers in Neuroscience, 2016 The molecular mechanisms underlying the pathophysiology of Alzheimer's disease (AD) are still not fully understood. In AD, Wnt/beta-catenin signaling has been shown to be downregulated while the peroxisome proliferator-activated receptor (PPAR) gamma ...
Alexandre Vallée, Yves Lecarpentier
exaly +2 more sources
Frontiers in Neurology, 2016 The opposite interplay between peroxisome proliferator-activated receptor gamma (PPAR gamma) and Wnt/beta-catenin signaling has led to the categorization of neurodegenerative diseases (NDs) as either NDs in which PPAR gamma is downregulated while the ...
Yves Lecarpentier, Alexandre Vallée
exaly +2 more sources
Frontiers in Physiology, 2014 Circadian clock mechanisms are far-from-equilibrium dissipative structures. Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta, and gamma) play a key role in metabolic regulatory processes, particularly in heart muscle.
Yves Lecarpentier, Jean-louis Hébert
exaly +2 more sources
Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML [PDF]
Mediterranean Journal of Hematology and Infectious DiseasesBackground: Acute myeloid leukaemia(AML) is a disease of the haematopoietic stem cells. Beta-catenin, a key element of the Wnt signalling, which is particularly active in various cancers.
Buket Altinok Gunes +10 more
doaj +2 more sources
Brain Metastases from Lung Cancer Show Increased Expression of DVL1, DVL3 and Beta-Catenin and Down-Regulation of E-Cadherin [PDF]
International Journal of Molecular Sciences, 2014 The susceptibility of brain to secondary formation from lung cancer primaries is a well-known phenomenon. In contrast, the molecular basis for invasion and metastasis to the brain is largely unknown.
Nives Pećina-Šlaus +2 more
exaly +4 more sources