Results 11 to 20 of about 1,125,892 (364)

Beta-catenin in disease

Journal of Oral and Maxillofacial Pathology, 2016
In continuation with the previous review on “β-catenin in health”, in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to
Sharada Prakash, U. Swaminathan, B. Nagamalini, A. Krishnamurthy   +3 more
semanticscholar   +5 more sources

Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors

BMC Research Notes, 2014
BackgroundSmall membrane-permeable molecules are now widely used during maintenance and differentiation of embryonic stem cells of different species.
Ortwin Naujok
exaly   +2 more sources

miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase

Neuro-Oncology, 2013
BACKGROUND Nemo-like kinase (NLK) is an evolutionarily conserved protein kinase involved in Wnt/beta-catenin signaling, which has been reported to be associated with gliomagenesis.
Kun Wang
exaly   +2 more sources

Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway

Oncogenesis, 2014
Salmonella infections can become chronic and increase the risk of cancer. The mechanisms by which specific Salmonella organisms contribute to cancer, however, are still unknown.
R. Lu, Shaoping Wu, Y. G. Zhang, Yinglin Xia, Xingyin Liu, Y. Zheng, H. Chen, K. Schaefer, Z. Zhou, M. Bissonnette, L. Li, Jun Sun   +11 more
exaly   +2 more sources

Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells

Cell Communication and Signaling, 2018
Background The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances its nuclear translocation.
Yuanyuan Tang, Joshua Berlind
exaly   +3 more sources

Nuclear beta-catenin in mesenchymal tumors [PDF]

Modern Pathology, 2004
Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony Ng, Allen M. Gown, Todd Barry, Maggie C.U. Cheang, Andy Chan, Dmitry Turbin, Forrest D. Hsu, Robert B. West, Torsten O. Nielsen   +8 more
openalex   +3 more sources

Beta-Catenin in Pseudoexfoliation Syndrome [PDF]

Applied Sciences, 2020
To find whether it is possible that beta-catenin, associated with the development of serious systemic diseases, as well as the neoplastic process, plays a role in the development of pseudoexfoliation syndrome (PEX). If so, identifying PEX, an age-related, vision-threatening disorder of elastic fibers, which is manifested in eyes by the accumulation of ...
Joanna Stafiej, Marta Hałas-Wiśniewska, Magdalena Izdebska, Maciej Gagat, Alina Grzanka, Grażyna Malukiewicz   +5 more
openaire   +3 more sources

β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. [PDF]

PLoS ONE, 2011
Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression.
Tobias Sinnberg, Moritz Menzel, Daniel Ewerth, Birgit Sauer, Michael Schwarz, Martin Schaller, Claus Garbe, Birgit Schittek   +7 more
doaj   +1 more source

GSK3beta is involved in JNK2-mediated beta-catenin inhibition. [PDF]

PLoS ONE, 2009
We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation.
Dong Hu, Xiuli Bi, Wenfeng Fang, Anjia Han, Wancai Yang   +4 more
doaj   +1 more source

CK1epsilon is required for breast cancers dependent on beta-catenin activity. [PDF]

PLoS ONE, 2010
Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date.To uncover genetic dependencies in
So Young Kim, Ian F Dunn, Ron Firestein, Piyush Gupta, Leslie Wardwell, Kara Repich, Anna C Schinzel, Ben Wittner, Serena J Silver, David E Root, Jesse S Boehm, Sridhar Ramaswamy, Eric S Lander, William C Hahn   +13 more
doaj   +1 more source