Results 11 to 20 of about 1,106,914 (319)
Journal of Oral and Maxillofacial Pathology, 2016 In continuation with the previous review on “β-catenin in health”, in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to
Sharada Prakash +3 more
semanticscholar +4 more sources
Beta-catenin cleavage enhances transcriptional activation [PDF]
Scientific Reports, 2018 AbstractNuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and cancer. Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat552).
Tatiana Goretsky +12 more
openalex +4 more sources
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Cell Death and Differentiation, 2022 The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang +14 more
semanticscholar +1 more source
Nuclear beta-catenin in mesenchymal tumors [PDF]
Modern Pathology, 2004 Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony Ng +8 more
openalex +3 more sources
Beta catenin mutated hepatic adenoma
, 2015 Jeremy Jones, Matt Morgan, Jeremy Jones
openalex +2 more sources
β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. [PDF]
PLoS ONE, 2011 Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression.
Tobias Sinnberg +7 more
doaj +1 more source
GSK3beta is involved in JNK2-mediated beta-catenin inhibition. [PDF]
PLoS ONE, 2009 We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation.
Dong Hu +4 more
doaj +1 more source
beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. [PDF]
PLoS ONE, 2010 beta-Catenin is a multifunctional protein involved in both signalling by secreted factors of Wnt family and regulation of the cellular architecture.
Dmitri Chilov +4 more
doaj +1 more source
CK1epsilon is required for breast cancers dependent on beta-catenin activity. [PDF]
PLoS ONE, 2010 Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date.To uncover genetic dependencies in
So Young Kim +13 more
doaj +1 more source