Results 11 to 20 of about 39,817 (237)

Recent Evolution of Susceptibility to Beta-Lactams in Neisseria meningitidis [PDF]

Antibiotics, 2023
Beta-lactams are the main antibiotics for the treatment of invasive meningococcal disease. However, reduced susceptibility to penicillin G is increasingly reported in Neisseria meningitidis and reduced susceptibility to third-generation cephalosporines ...
Ala-Eddine Deghmane, Eva Hong, Muhamed-Kheir Taha   +2 more
doaj   +2 more sources

Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review [PDF]

Frontiers in Antibiotics
Orthotopic liver transplant (OLT) represents the standard of care for managing patients affected by end-stage and life-threatening liver diseases.
Milo Gatti, Milo Gatti, Federico Pea, Federico Pea   +3 more
doaj   +2 more sources

Extended Infusion of Beta-Lactams and Glycopeptides: A New Era in Pediatric Care? A Systematic Review and Meta-Analysis [PDF]

Antibiotics
Optimizing antibiotic therapy is imperative with rising bacterial resistance and high infection mortality. Extended infusion defined as a continuous infusion (COI) or prolonged infusion (PI) of beta-lactams and glycopeptides might improve efficacy and ...
Andrea Rahel Burch, Lukas von Arx, Barbara Hasse, Vera Neumeier   +3 more
doaj   +2 more sources

Rise of the beta-lactams: a retrospective, comparative cohort of oral beta-lactam antibiotics as step-down therapy for hospitalized adults with acute pyelonephritis [PDF]

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.
Athena L.V. Hobbs, Vagish S. Hemmige, Katie L. Reel, Theresa C. Jaso, Dusten T. Rose, Katherine M. Shea   +5 more
doaj   +2 more sources

The current view on betalactam resistance in Staphylococcus aureus [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2021
The review presents the current view on the different resistance mechanisms of Staphylococcus aureus to beta-lactams, which are ones of the main antibiotics of choice for the treatment of staphylococcal infections. Currently, there are several mechanisms
Gostev V.V., Punchenko O.E., Sidorenko S.V.   +2 more
doaj   +1 more source

Hypotheses for synthesis of novel chiral beta-amino-beta-lactams through amidines

Results in Chemistry, 2021
Synthesis of new beta-lactams is an attractive field because some of these types of molecules are biologically active. The design and preparation of C4-nitrogen-substituted beta-lactams are not known.
Bimal Krishna Banik, Alberto Boretti
doaj   +1 more source

Clinical aspects of severe cutaneous adverse reactions caused by beta-lactam antibiotics: A study from the Korea SCAR registry

World Allergy Organization Journal, 2023
Background: Although beta-lactams are 1 of the major causative agents of severe cutaneous adverse reactions (SCAR), their epidemiology and clinical aspects have been poorly studied.
Min-Hye Kim, MD, PhD, Dong Yoon Kang, MD, PhD, Young-Hee Nam, MD, PhD, Da Woon Sim, MD, PhD, Sujeong Kim, MD, Jun Kyu Lee, MD, PhD, Jung-Won Park, MD, PhD, Hye-Kyung Park, MD, PhD, Jae-Woo Jung, MD, PhD, Cheol-Woo Kim, MD, PhD, Min-Suk Yang, MD, PhD, Joo-Hee Kim, MD, PhD, Young-Min Ye, MD, PhD, Young-Il Koh, MD, PhD, Hye-Ryun Kang, MD, PhD, Seoung Ju Park, Sae-Hoon Kim   +16 more
doaj   +1 more source

Beta-Lactams Dosing in Critically Ill Patients with Gram-Negative Bacterial Infections: A PK/PD Approach

Antibiotics, 2021
Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on the percentage of dosing interval that the concentration remains ...
Kelly L. Maguigan, Mohammad H. Al-Shaer, Charles A. Peloquin   +2 more
doaj   +1 more source

Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant Staphylococcus aureus

Frontiers in Molecular Biosciences, 2021
Methicillin-resistant S. aureus (MRSA) are resistant to beta-lactams, but synergistic activity between beta-lactams and glycopeptides/lipopeptides is common.
Rutan Zhang, Ismael A. Barreras Beltran, Nathaniel K. Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A. Holmes, Kelly M. Hines, Stephen J. Salipante, Libin Xu, Brian J. Werth   +9 more
doaj   +1 more source

Which Are the Best Regimens of Broad-Spectrum Beta-Lactam Antibiotics in Burn Patients? A Systematic Review of Evidence from Pharmacology Studies

Antibiotics, 2023
Background: Burn injury causes profound pathophysiological changes in the pharmacokinetic/pharmacodynamic (PK/PD) properties of antibiotics. Infections are among the principal complications after burn injuries, and broad-spectrum beta-lactams are the ...
Gianpiero Tebano, Giulia la Martire, Luigi Raumer, Monica Cricca, Davide Melandri, Federico Pea, Francesco Cristini   +6 more
doaj   +1 more source