Results 31 to 40 of about 39,817 (237)
Frontiers in Cellular and Infection Microbiology, 2023 The lack of effective therapeutics against emerging multi-drug resistant strains of Mycobacterium tuberculosis (Mtb) prompts the identification of novel anti-tuberculosis targets.
Cátia Silveiro +10 more
doaj +1 more source
β-Lactam Allergy and Cross-Reactivity: A Clinician’s Guide to Selecting an Alternative Antibiotic
Journal of Asthma and Allergy, 2021 Cristiano Caruso,1 Rocco Luigi Valluzzi,2 Stefania Colantuono,1 Francesco Gaeta,1 Antonino Romano3,4 1Allergy Unit, Columbus Hospital, Fondazione Policlinico A.
Caruso C +4 more
doaj
Antibiotics, 2021 Selective pressure of beta-lactams is thought to be responsible for mutation selection in methicillin-susceptible Staphylococcus aureus (MSSA). We used next-generation sequencing to compare the genomes of beta-lactamase-positive (SA0707) and -negative ...
Vladimir Gostev +6 more
doaj +1 more source
Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors
Frontiers in Microbiology, 2022 Beta-lactams have been excluded from tuberculosis therapy due to the intrinsic resistance of Mycobacterium tuberculosis (Mtb) to this antibiotic class, usually attributed to a potent beta-lactamase, BlaC, and to an unusually complex cell wall.
Francisco Olivença +8 more
doaj +1 more source
Zagazig Journal of Pharmaceutical Sciences, 2016 This study aimed for the molecular detection of TEM and SHV genes in Extended-Spectrum beta-lactamases (ESBLs) clinical isolates of Enterobacteriace (Eshericichia coli, Klebsiella pneumoniae and Proteus spp.).
Ashraf Kadry +2 more
doaj +1 more source
Beta‐lactam versus beta‐ lactam/macrolide therapy in pediatric outpatient pneumonia [PDF]
Pediatric Pulmonology, 2015 SummaryObjectiveThe objective was to evaluate the comparative effectiveness of beta‐lactam monotherapy and beta‐ lactam/macrolide combination therapy in the outpatient management of children with community‐acquired pneumonia (CAP).MethodsThis retrospective cohort study included children, ages 1–18 years, with CAP diagnosed between January 1, 2008 and ...
Lilliam, Ambroggio +6 more
openaire +2 more sources
Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
Southern Clinics of Istanbul Eurasia, 2020 INTRODUCTION[|]In recent years, carbapenem-resistant Klebsiella pneumoniae infections have become an important health problem in our country and all over the world.
Pınar Kıran +2 more
doaj +1 more source
Profile of Enterobacteria Resistant to Beta-Lactams
Antibiotics, 2020 A serious emerging problem worldwide is increased antimicrobial resistance. Acquisition of coding genes for evasion methods of antimicrobial drug mechanisms characterizes acquired resistance. This phenomenon has been observed in Enterobacteriaceae family.
Andressa Liberal Santos +14 more
doaj +1 more source
Angewandte Chemie, EarlyView.Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang +6 more
wiley +2 more sources
Photochemical Cyclization of Tertiary Buta‐2,3‐dienamides to β‐Lactams Upon Triplet Energy Transfer
Angewandte Chemie, EarlyView.Energy transfer is the key to the successful photocyclization of the title compounds to 3,4‐disubstituted 2‐azetidinones. If the substituent at the nitrogen atom is primary (R2 = H), trans products are formed exclusively. The triplet state of xanthen‐9‐one (XT) was found to be quenched by an allene amide (R, R2 = H, R1 = Bn, and R3 = Ph) with a ...
Johannes Hofer +3 more
wiley +2 more sources