Brain Beta-Catenin Signalling During Stress and Depression
Neurosignals, 2018 Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway.
Chuin Hau Teo +2 more
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Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer. [PDF]
Cell Death Differ, 2022 The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Wang Y +14 more
europepmc +2 more sources
The axis-inducing activity, stability and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3 [PDF]
Genes & Development, 1996 The serine/threonine kinase Xgsk-3 and the intracellular protein beta-catenin are necessary for the establishment of the dorsal-ventral axis in Xenopus.
C. Yost +5 more
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Journal of Oral and Maxillofacial Pathology, 2016 In continuation with the previous review on “β-catenin in health”, in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to
Sharada Prakash +3 more
semanticscholar +5 more sources
A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma [PDF]
Frontiers in Endocrinology, 2023 BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC).
Enzo Lalli, Enzo Lalli, Enzo Lalli
doaj +2 more sources
Beta-catenin expression in psoriasis
Indian Dermatology Online Journal, 2015 Background: Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion.
Mohamed Abd El-wahed Gaber +3 more
semanticscholar +5 more sources
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. [PDF]
PLoS ONE, 2009 The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin.
Ali M Riazi +7 more
doaj +6 more sources
Nuclear beta-catenin in mesenchymal tumors [PDF]
Modern Pathology, 2004 Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony Ng +8 more
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Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML [PDF]
Mediterranean Journal of Hematology and Infectious DiseasesBackground: Acute myeloid leukaemia(AML) is a disease of the haematopoietic stem cells. Beta-catenin, a key element of the Wnt signalling, which is particularly active in various cancers.
Buket Altinok Gunes +10 more
doaj +2 more sources
Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex [PDF]
The EMBO Journal, 2001 The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats. We have determined the crystal structure of a 15 amino acid beta-catenin binding repeat from APC bound to the ...
K.E. Spink
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