A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma [PDF]
Frontiers in Endocrinology, 2023 BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC).
Enzo Lalli, Enzo Lalli, Enzo Lalli
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Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML [PDF]
Mediterranean Journal of Hematology and Infectious DiseasesBackground: Acute myeloid leukaemia(AML) is a disease of the haematopoietic stem cells. Beta-catenin, a key element of the Wnt signalling, which is particularly active in various cancers.
Buket Altinok Gunes +10 more
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β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. [PDF]
PLoS ONE, 2011 Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression.
Tobias Sinnberg +7 more
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GSK3beta is involved in JNK2-mediated beta-catenin inhibition. [PDF]
PLoS ONE, 2009 We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation.
Dong Hu +4 more
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beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. [PDF]
PLoS ONE, 2010 beta-Catenin is a multifunctional protein involved in both signalling by secreted factors of Wnt family and regulation of the cellular architecture.
Dmitri Chilov +4 more
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CK1epsilon is required for breast cancers dependent on beta-catenin activity. [PDF]
PLoS ONE, 2010 Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date.To uncover genetic dependencies in
So Young Kim +13 more
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. [PDF]
PLoS Medicine, 2007 BACKGROUND: Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair would substantially improve patient outcome.
Yan Chen +6 more
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Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. [PDF]
PLoS ONE, 2009 The Wnt/beta-catenin signaling pathway plays essential roles in cell proliferation and differentiation, and deregulated beta-catenin protein levels lead to many types of human cancers.
Geng Wu +3 more
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Beta-catenin signaling negatively regulates intermediate progenitor population numbers in the developing cortex. [PDF]
PLoS ONE, 2010 Intermediate progenitor cells constitute a second proliferative cell type in the developing mammalian cerebral cortex. Little is known about the factors that govern the production of intermediate progenitors.
Christopher A Mutch +3 more
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The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. [PDF]
PLoS ONE, 2008 We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by beta-catenin, including the stem cell marker keratin 15, contain vitamin D response elements (VDREs) and several are induced ...
Héctor G Pálmer +4 more
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