Beta-Catenin in Pseudoexfoliation Syndrome [PDF]
Applied Sciences, 2020 To find whether it is possible that beta-catenin, associated with the development of serious systemic diseases, as well as the neoplastic process, plays a role in the development of pseudoexfoliation syndrome (PEX). If so, identifying PEX, an age-related, vision-threatening disorder of elastic fibers, which is manifested in eyes by the accumulation of ...
Joanna Stafiej +5 more
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β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. [PDF]
PLoS ONE, 2011 Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression.
Tobias Sinnberg +7 more
doaj +1 more source
GSK3beta is involved in JNK2-mediated beta-catenin inhibition. [PDF]
PLoS ONE, 2009 We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation.
Dong Hu +4 more
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CK1epsilon is required for breast cancers dependent on beta-catenin activity. [PDF]
PLoS ONE, 2010 Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date.To uncover genetic dependencies in
So Young Kim +13 more
doaj +1 more source
beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. [PDF]
PLoS ONE, 2010 beta-Catenin is a multifunctional protein involved in both signalling by secreted factors of Wnt family and regulation of the cellular architecture.
Dmitri Chilov +4 more
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β-catenin takes a HIT [PDF]
Cell Cycle, 2008 Histidine triad (HIT) proteins represent a small family of nucleotide-binding and -hydrolyzing proteins, which attracted the attention of cancer biologists because their expression is lost in multiple human malignancies. To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned.
Jörg Weiske, Otmar Huber
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MicroRNA roles in beta-catenin pathway [PDF]
Molecular Cancer, 2010 Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Tao Jiang +11 more
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. [PDF]
PLoS Medicine, 2007 BACKGROUND: Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair would substantially improve patient outcome.
Yan Chen +6 more
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In melanoma, beta-catenin is a suppressor of invasion [PDF]
Oncogene, 2011 Cell-type-specific signalling determines cell fate under physiological conditions, but it is increasingly apparent that also in cancer development the impact of any given oncogenic pathway on the individual cancer pathology is dependent on cell-lineage-specific molecular traits.
Arozarena, I +5 more
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Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. [PDF]
PLoS ONE, 2009 The Wnt/beta-catenin signaling pathway plays essential roles in cell proliferation and differentiation, and deregulated beta-catenin protein levels lead to many types of human cancers.
Geng Wu +3 more
doaj +1 more source