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Sequential analysis of Durham and Flournoy's biased coin design for phase I clinical trials
2023In a phase I clinical trial, we are interested in finding a dose mu that will produce toxicity at an acceptable probability level Gamma in the target population. We investigate various estimators of the target dose mu to be used with the up-and-down Biased Coin Design (BCD) introduced by Durham and Flournoy (1994).
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Doubly adaptive biased coin design to improve Bayesian clinical trials with time‐to‐event endpoints
Statistics in MedicineClinical trialists often face the challenge of balancing scientific questions with other design features, such as improving efficiency, minimizing exposure to inferior treatments, and simultaneously comparing multiple treatments. While Bayesian response adaptive randomization (RAR) is a popular and effective method for achieving these objectives, it is
Wenhao Cao +4 more
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Using the Biased Coin Design for Randomization in Health Care Research
Western Journal of Nursing Research, 1991openaire +2 more sources
Maximum Tolerated Dose Estimation Applied Biased Coin Design in a Phase I Clinical Trial
Communications for Statistical Applications and Methods, 2012Dongjae Kim
exaly
Adaptive randomization biased coin design: Experience in a cooperative group clinical trial
Controlled Clinical Trials, 1980John F. Hannigan +4 more
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