Results 111 to 120 of about 5,006 (131)
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A two-dimensional biased coin design for dual-agent dose-finding trials
Clinical Trials, 2015Background: Given the limited efficacy observed with single agents, there is growing interest in Phase I clinical trial designs that allow for identification of the maximum tolerated combination of two agents.
Zhichao, Sun, Thomas M, Braun
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The adaptive accelerated biased coin design for phase I clinical trials
Journal of Applied Statistics, 2011Phase I clinical trials are designed to study several doses of the same drug in a small group of patients to determine the maximum tolerated dose (MTD), which is defined as the dose that is associated with dose-limiting toxicity (DLT) in a desired fraction Γ of patients.
Nan Jia, Thomas M. Braun
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Sequential Monitoring of Conditional Randomization Tests: Generalized Biased Coin Designs
Sequential Analysis, 2008Abstract For the generalized biased coin class of randomization procedures, Smythe (1988) proved asymptotic normality of the conditional linear rank test. Clinical trialists often undertake interim analysis to determine whether to stop the trial early for a substantial treatment effect.
Yanqiong Zhang, William F. Rosenberger
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Optimum biased coin designs for sequential clinical trials with prognostic factors
Biometrika, 1982Patients in a clinical trial arrive sequentially and are assigned to one of t treatments. This assignment should maintain a balance between the numbers receiving each treatment, yet should be sufficiently random to avoid any suspicion of conscious or unconscious cheating. To balance these requirements Efron (1971) introduced biased coin designs for the
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Statistics in Medicine, 2005
Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments.
A C, Atkinson, A, Biswas
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Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments.
A C, Atkinson, A, Biswas
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Biometrika, 2011
The present paper deals with sequential designs intended to balance the allocations of two competing treatments in the presence of prognostic factors. After giving a theoretical framework on the optimality of balanced designs that can arise when covariates are taken into account, we propose a new family of covariate-adaptive randomized designs that ...
BALDI ANTOGNINI, ALESSANDRO +1 more
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The present paper deals with sequential designs intended to balance the allocations of two competing treatments in the presence of prognostic factors. After giving a theoretical framework on the optimality of balanced designs that can arise when covariates are taken into account, we propose a new family of covariate-adaptive randomized designs that ...
BALDI ANTOGNINI, ALESSANDRO +1 more
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Optimum biased-coin designs for sequential treatment allocation with covariate information
Statistics in Medicine, 1999Randomized optimum designs of biased-coin type are compared with other strategies for the sequential allocation of two or more treatments in a clinical trial. The emphasis is on the variance of estimated treatment contrasts. This variance, which depends on the design strategy employed, may be interpreted as the number of patients on whom information is
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Which design is better? Ehrenfest urn versus biased coin
Advances in Applied Probability, 2000Two features are desired in designing a sequential clinical trial: randomness and balance. The former makes the ground for valid statistical inferences and the latter strengthens efficiency in inference procedures. Unfortunately randomness and balance can be in conflict with one another, and clinicians may be caught between the need for both of them ...
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The doubly adaptive biased coin design for sequential clinical trials
Journal of Statistical Planning and Inference, 1994zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Reparametrized Firth's Logistic Regressions for Dose‐Finding Study With the Biased‐Coin Design
Pharmaceutical StatisticsABSTRACTFinding an adequate dose of the drug by revealing the dose–response relationship is very crucial and a challenging problem in the clinical development. The main concerns in dose‐finding study are to identify a minimum effective dose (MED) in anesthesia studies and maximum tolerated dose (MTD) in oncology clinical trials.
Hyungwoo Kim +3 more
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