Results 31 to 40 of about 211,042 (267)

Application of isotonic regression in estimating EDg and its 95% confidence interval by bootstrap method for a biased coin up-and-down sequential dose-finding design

Indian Journal of Anaesthesia, 2023
Newer anaesthetic drugs introduced in practice and older drugs for novel route or indication has led to the need to determine the optimal dose. In this context, two most recent studies, for example, estimated the effective dose of opioids for epidural ...
Chitralok Hemraj, Mani Kalaivani, Harsha Binu, Rashmi Ramachandran   +3 more
doaj   +2 more sources

A Sequential Probability Ratio Test Using a Biased Coin Design

Annals of Statistics, 1985
Consider a sequential probability ratio test comparing two treatments, where each subject receives only one of the treatments. Each subject's treatment assignment is determined by the flip of a biased coin, where the bias serves to balance the number of patients assigned to each treatment.
Nancy E Heckman
exaly   +3 more sources

Age-Stratified ED95 of Remimazolam Tosilate for Moderate Sedation in Pediatric Patients: A Biased Coin Design Study

Drug Design, Development and Therapy
Bingqing Zhu,* Wenjun Meng,* Kunyun Pan,* Li Peng, Xu Chen, Sheng Wang, Chengwei Yang Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and ...
Zhu B, Meng W, Pan K, Peng L, Chen X, Wang S, Yang C   +6 more
doaj   +2 more sources

Generalized Efron's biased coin design and its theoretical properties

Journal of Applied Probability, 2016
AbstractIn clinical trials with two treatment arms, Efron's biased coin design, Efron (1971), sequentially assigns a patient to the underrepresented arm with probabilityp> ½. Under this design the proportion of patients in any arm converges to ½, and the convergence rate isn-1, as opposed ton-½under some other popular designs.
Yanqing Hu
openaire   +4 more sources

A Local Limit Theorem for a Biased Coin Design for Sequential Tests

Annals of Statistics, 1985
In a clinical comparison of responses to two treatments, patients are admitted sequentially and given one of the two treatments. The allocation is determined randomly, to decrease the possibility of personal bias in the selection of subjects for the test.
Nancy E Heckman
exaly   +3 more sources

Sequential Treatment Allocation Using Biased Coin Designs

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1984
SUMMARY Biased coin designs are used in clinical trials as a means of achieving approximate balance within a randomized design. In this paper, detailed results are obtained for a class of biased coin designs from the point of view of the degree of balance achieved, selection bias, accidental bias and inference following the randomized ...
exaly   +3 more sources

Properties of Biased Coin Designs in Sequential Clinical Trials

Annals of Statistics, 1984
Several authors have proposed and studied designs in a clinical trial experiment of testing treatments. For example \textit{B. Efron} [cf. Biometrika 58, 403-417 (1971; Zbl 0226.62086)] proposed and studied a sequential biased design for two treatments \(R=2\).
exaly   +4 more sources

Determining the optimal ropivacaine concentration for spinal anaesthesia during day surgery for anorectal procedures: a dose-finding study [PDF]

Scientific Reports
Ropivacaine is a commonly utilized local anesthetic for spinal anesthesia (SA); however, its optimal concentration for elective anorectal surgery has not been thoroughly estimated.
Lu Chen, Xujun Dong, Jianhua Chen, Jintao Shen, Jian Liu, Shaojin Bu, Rongdan Tan, Xin-sen Zou   +7 more
doaj   +2 more sources

The 90% effective dose (ED90) of esketamine for inhibiting responses to intraoperative motor stimulation during ambulatory hysteroscopy: a biased-coin up-and-down sequential allocation trial [PDF]

BMC Anesthesiology
Background Esketamine and remimazolam co-administration presents a viable opioid-free anesthetic alternative for outpatient hysteroscopy. This study was designed to ascertain the ED90 of esketamine for inhibiting intraoperative movement responses in ...
Ruiqi Zhang, Chen Wang, Lin Wang, Wenyue Kang, Zhihua Wang   +4 more
doaj   +2 more sources

Minimum Effective Volume of Liposomal Bupivacaine for Interscalene Block in Arthroscopic Rotator Cuff Repair: A Prospective, Biased-Coin Up-and-Down Dose-Finding Study. [PDF]

Drug Des Devel Ther
Background Establishing the minimum effective volume (MEV90) of liposomal bupivacaine for ultrasound‑guided interscalene brachial plexus block (ISB) is essential to optimize postoperative analgesia and minimize local anesthetic–related side effects in ...
Wang HT, Xue Q, Li HJ, Zhao YY, Tian K, Yang JJ.   +5 more
europepmc   +2 more sources