Determination of the 90% Effective Dose of Remimazolam Continuous Infusion for Preventing Emergence Delirium in Pediatric Patients Undergoing Adenoidectomy or Adenotonsillectomy with Sevoflurane: A Biased Coin Up-and-Down Sequential Trial Design. [PDF]
Drug Des Devel TherBackground Emergence delirium (ED) is a common postoperative complication during the recovery period in pediatric anesthesia. Continuous intravenous infusion of remimazolam can effectively prevent the occurrence of ED.
Yang ZS, Li D, Jiang Y, Xiao F, Yan HY.
europepmc +2 more sources
The 90% effective dose of spinal ropivacaine for external cephalic version: A sequential dose-finding study [PDF]
Journal of International Medical ResearchObjective Although spinal anesthesia can improve the success of external cephalic version, the optimal analgesic dose of ropivacaine remains undefined, and higher doses may increase potential risks. This study aimed to determine the 90% effective dose of
Qiao Shi +4 more
doaj +2 more sources
Indian Journal of AnaesthesiaBackground and Aims: The femoral nerve (FN) is commonly blocked using ropivacaine to provide postoperative analgesia after knee surgery. However, the minimal required concentration has not yet been defined.
Ahmed M. Taha +5 more
doaj +2 more sources
The EC90 of remifentanil for blunting cardiovascular responses to head fixation for neurosurgery under total intravenous anesthesia with propofol and remifentanil based on bispectral index monitoring: estimation with the biased coin up-and-down sequential method [PDF]
BMC Anesthesiology, 2017 Background Head fixation can induce hemodynamic instability. Remifentanil is commonly used with propofol for total intravenous anesthesia (TIVA) during neurosurgery.
Jung-Man Lee +4 more
doaj +3 more sources
Correction: ED90 of intravenous remimazolam for alleviating preoperative anxiety in children: a prospective dose-finding study [PDF]
Frontiers in MedicineXu-ming Zhu +5 more
doaj +2 more sources
Frontiers in Pharmacology, 2023 Background and Purpose: The prevalence of elderly patients prompts anesthesiologists to determine the optimal dose of medication due to the altered pharmacokinetics and pharmacodynamics of this population.
Liangchao Qu +7 more
doaj +1 more source
ED95 of remimazolam in nasal administration for attenuating preoperative anxiety in children
Frontiers in Medicine, 2023 BackgroundPreoperative anxiety often prevails in children at higher levels than adults, which is a common impediment for surgeons and anesthesiologists. It is of great necessity to explore an appropriate medication to improve this situation. Remimazolam,
Xiang Long +6 more
doaj +1 more source
Randomizing a clinical trial in neuro-degenerative disease
Contemporary Clinical Trials Communications, 2023 The paper studies randomization rules for a sequential two-treatment, two-site clinical trial in Parkinson’s disease. An important feature is that we have values of responses and five potential prognostic factors from a sample of 144 patients similar to ...
Anthony C. Atkinson +3 more
doaj +1 more source
Covariate-Adaptive Biased Coin Randomization for Master Protocols with Multiple Interventions and Biomarker-Stratified Allocation [PDF]
, 2023 In a multi-arm trial with predefined subgroups for each intervention to target, it is often desirable to enrich assignment to an intervention by enrolling more biomarker-positive participants to the intervention.
Ivanova, Anastasia +2 more
core +2 more sources
PLoS ONE, 2021 BackgroundCaudal epidural block (CEB) provides reliable anesthesia for adults undergoing anorectal surgery. Despite the widely utilization, the minimum effective concentration for 90% patients (MEC90) of ropivacaine for CEB remains unknown.ObjectiveTo ...
Xuehan Li +6 more
doaj +1 more source