Results 21 to 30 of about 9,554,500 (221)

A doubly adaptive biased coin design.

, 1991
A doubly adaptive biased coin design is formulated for the allocation of patients to treatments A and B in a clinical trial. The design is doubly adaptive in the sense that it takes account of the proportion of patients assigned to each treatment and the
Eisele, Jeffrey Robert
core   +7 more sources

Optimal Programmed Intermittent Epidural Bolus Interval for Video-Assisted Thoracic Surgery Lobectomy: A Biased-Coin Up-Down Study of Ropivacaine-Sufentanil [PDF]

Drug Design, Development and Therapy
Chengfei Feng,1,* Jijin Wen,2,* Guozhong Lai,3,* Xiaofan Lu,2 Guanli Luo,2 Yali Lu,2 Wei Li,2 Renchun Lai2 1Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University ...
Feng C, Wen J, Lai G, Lu X, Luo G, Lu Y, Li W, Lai R   +7 more
doaj   +2 more sources

Determination of the 95% effective dose of remimazolam tosylate in anesthesia induction inhibits endotracheal intubation response in senile patients

Frontiers in Pharmacology, 2023
Background and Purpose: The prevalence of elderly patients prompts anesthesiologists to determine the optimal dose of medication due to the altered pharmacokinetics and pharmacodynamics of this population.
Liangchao Qu, Mei Liu, Ru Ouyang, Tianyuan Li, Dingde Long, Yao Jiang, Chengyu Wang, Liqin Cheng   +7 more
doaj   +1 more source

ED95 of remimazolam in nasal administration for attenuating preoperative anxiety in children

Frontiers in Medicine, 2023
BackgroundPreoperative anxiety often prevails in children at higher levels than adults, which is a common impediment for surgeons and anesthesiologists. It is of great necessity to explore an appropriate medication to improve this situation. Remimazolam,
Xiang Long, Li-xia Wen, Hu Yang, Guo-hong Zhu, Qing-yun Zhang, Jing-jing Jiang, Yuan Gong   +6 more
doaj   +1 more source

Randomizing a clinical trial in neuro-degenerative disease

Contemporary Clinical Trials Communications, 2023
The paper studies randomization rules for a sequential two-treatment, two-site clinical trial in Parkinson’s disease. An important feature is that we have values of responses and five potential prognostic factors from a sample of 144 patients similar to ...
Anthony C. Atkinson, Belmiro P.M. Duarte, David J. Pedrosa, Marlena van Munster   +3 more
doaj   +1 more source

Bayesian and other biased-coin designs for sequential clinical trials

, 1999
A relationship is established between the Bayesian biased-coin design suggested by Ball et al. (1993) [F. G. Ball, A. F. M. Smith, I. Verdinelli: Biased coin designs with a Bayesian bias, J. Statist. Plann.
Atkinson, Anthony
core   +6 more sources

Nuovi indicatori di sbilanciamento e prevedibilità nei disegni sequenziali randomizzati: confronti fra 'biased coin designs' diversi

Statistica, 2007
Efron's (1971) Biased Coin Design is a well-known randomization technique of sequential clinical trials for comparing two treatments in the absence of prognostic factors that helps neutralize selection bias while keeping the experiment fairly balanced ...
Alessandro Baldi Antognini, Antonella Bodini, Alessandra Giovagnoli   +2 more
doaj   +1 more source

The estimation of minimum effective volume of 0.5% ropivacaine in ultrasound-guided interscalene brachial plexus nerve block: A clinical trial

Journal of Anaesthesiology Clinical Pharmacology, 2019
Background and Aims: Interscalene brachial plexus block (ISB) is the most commonly used mode of anesthesia for upper limb surgeries. Higher volume of local anesthetic used in ISB is associated with increased incidence of side effects, particularly ...
Kailash Mittal, Sarita Janweja, Prateek, Pushpender Sangwan, Deepa Agarwal, Himani Tak   +5 more
doaj   +1 more source

Robust quantum state engineering through coherent localization in biased-coin quantum walks

EPJ Quantum Technology, 2018
We address the performance of a coin-biased quantum walk as a generator for non-classical position states of the walker. We exploit a phenomenon of coherent localization in the position space - resulting from the choice of small values of the coin ...
Helena Majury, Joelle Boutari, Elizabeth O’Sullivan, Alessandro Ferraro, Mauro Paternostro   +4 more
doaj   +1 more source

The minimum effective concentration (MEC90) of ropivacaine for ultrasound-guided caudal block in anorectal surgery. A dose finding study.

PLoS ONE, 2021
BackgroundCaudal epidural block (CEB) provides reliable anesthesia for adults undergoing anorectal surgery. Despite the widely utilization, the minimum effective concentration for 90% patients (MEC90) of ropivacaine for CEB remains unknown.ObjectiveTo ...
Xuehan Li, Jun Li, Pei Zhang, Huifei Deng, Mingan Yang, Hongbo He, Rurong Wang   +6 more
doaj   +1 more source