Results 1 to 10 of about 1,440 (106)

Comparison of the Effective Dose 90 (ED90) and Clinical Outcomes of Fentanyl Versus Esketamine for Analgesia in Hysteroscopy: A Two-Part, Randomized, Double-Blind Trial [PDF]

Drug Design, Development and Therapy
Jun Du, Chan Li, Mei Huang, Xiarong Qin Department of Anesthesiology, Zhejiang Hospital, Hangzhou, Zhejiang, 310030, People’s Republic of ChinaCorrespondence: Xiarong Qin, Department of Anesthesiology, Zhejiang Hospital, Hangzhou, Zhejiang, 310030 ...
Jun Du
exaly   +4 more sources

ED90 of Remimazolam for Moderate Sedation in Children Undergoing Neurosurgery. [PDF]

Drug Design, Development and Therapy
Fei-Yu Tao,1,* Yan-Jie Yang,2,* Lu-Chao Gao,2,* Yu Li,3 Yi-Wei Li,4 Dong-Liang Mu,1 Xin-Lin Hou,5 Dong-Xin Wang1 1Department of Anesthesiology, Peking University First Hospital, Beijing, People’s Republic of China; 2Department of ...
Dong-Xin Wang
exaly   +4 more sources

Determination of ED90 and ED99 of Oliceridine combined with Propofol in inhibiting responses to gastroscope insertion: a biased coin up-and-down design [PDF]

BMC Anesthesiology
Background Gastroscopy is a common medical procedure, but the insertion of the endoscope often causes significant discomfort and anxiety in patients, necessitating effective sedation strategies.
Zhiyong Tang, Guangfen Yin, Yaohan Yu, Yinghong Luo, Shuqin Tian, Qingdong Zhang, Yanwei Fang, Qinghang Xuan   +7 more
exaly   +3 more sources

Determination of the 90% effective dose of propofol combined with oliceridine or fentanyl for inhibiting the insertion response in upper gastrointestinal endoscopy: a dose-finding trial [PDF]

Frontiers in Medicine
BackgroundPropofol combined with opioids is commonly used for procedural sedation, enhancing patient tolerance and reducing the incidence of adverse events. This study aimed to determine the 90% effective dose (ED90) of propofol combined with fentanyl or
Fangsheng Xu, Yuanyuan Cui, Ye Huang, Jian Tang, Yuan Xu, Mingcong Wang, Mengqi Liu, Kehui Qu, Jianfeng Pu, Meifang Wang, Qian Wang   +10 more
doaj   +2 more sources

Experimental Evolution of Reduced Susceptibility to Artemether-Lumefantrine in <i>Plasmodium berghei</i> Following Serial Drug Pressure. [PDF]

J Parasitol Res
Malaria remains a major global health problem, with uneven progress and the greatest disease burden clustered in sub‐Saharan Africa. Antimalarial drug resistance continues to undermine malaria control efforts, with widespread resistance reported in Plasmodium falciparum, including reduced susceptibility to artemisinin‐based combination therapies (ACTs).
Njoroge SM, Kimani SK, Ngonjo TW, Olunga MS, Seng Ete Wambua J, Waithera MW, Wawa HY, Ng Ang A Waweru J.   +7 more
europepmc   +2 more sources

ED90 of intravenous remimazolam for alleviating preoperative anxiety in children: a prospective dose-finding study [PDF]

Frontiers in Medicine
BackgroundChildren’s minds are immature, making them more susceptible to severe anxiety when separated from their parents before surgery. Alleviating preoperative anxiety in children is essential for providing comfort-oriented healthcare.
Xu-ming Zhu, Xiao-yong Wei, Qian-yu Guo, Pei-pei Hao, Le-ting Ji, Chang-sheng Li   +5 more
doaj   +2 more sources

The 90% effective dose of remimazolam in combination with sufentanil for sedation in patients undergoing gastroscopy [PDF]

Frontiers in Medicine
ObjectiveTo determine the 90% effective dose (ED90) of remimazolam in combination with sufentanil for sedation in patients undergoing gastroscopy.MethodsFifty-six patients aged 18–65 years with ASA physical status I–II and a BMI of 18–30 kg/m2 who were ...
Yan Chen, Fan Jin, Wenjie Wang, Hongwei Wang   +3 more
doaj   +2 more sources

Effective Dose 90 of Programmed Intermittent Epidural Bolus Volume at Three Ropivacaine Concentrations with Dural Puncture Epidural for Labor Analgesia: A Randomized Sequential Allocation Study [PDF]

Drug Design, Development and Therapy
Linsen Sun, Xiaojuan Ding, Peng Zhai, Yan Jiang, Meijuan Sun, Xiangsheng XiongDepartment of Anesthesiology, Huai’an Hospital Affiliated to Yangzhou University (The Fifth People’s Hospital of Huai’an), Huaian, People’s Republic of China&ast;These ...
Sun L, Ding X, Zhai P, Jiang Y, Sun M, Xiong X   +5 more
doaj   +2 more sources

Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery [PDF]

Drug Design, Development and Therapy
Xiaolin Tang,1,&ast; Yu Liang,1,&ast; Yuting Hu,1 Peng Li,1 Jiani Wang,1 Yujue Wang,2 Min Xie1 1Department of Anaesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China ...
Tang X, Liang Y, Hu Y, Li P, Wang J, Wang Y, Xie M   +6 more
doaj   +2 more sources

ED90 of epidural esketamine with 0.075% ropivacaine for labor analgesia in nulliparous parturients: a prospective, randomized and dose-finding study

Frontiers in Pharmacology, 2023
Background: Because it has been reported that racemic ketamine had a local anesthetic-sparing effect when used for epidural analgesia this would suggest the likelihood of a potential advantage (less pruritus) over opioid drugs.
Zhong Mei
exaly   +3 more sources