Results 11 to 20 of about 211,042 (267)

A new 'biased coin design' for the sequential allocation of two treatments [PDF]

Journal of the Royal Statistical Society Series C: Applied Statistics, 2004
SummaryEfron’s biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties of ...
Alessandro Baldi Antognini, Alessandra Giovagnoli   +1 more
exaly   +9 more sources

Determination of ED90 and ED99 of Oliceridine combined with Propofol in inhibiting responses to gastroscope insertion: a biased coin up-and-down design [PDF]

BMC Anesthesiology
Background Gastroscopy is a common medical procedure, but the insertion of the endoscope often causes significant discomfort and anxiety in patients, necessitating effective sedation strategies.
Zhiyong Tang, Guangfen Yin, Yaohan Yu, Yinghong Luo, Shuqin Tian, Qingdong Zhang, Yanwei Fang, Qinghang Xuan   +7 more
doaj   +5 more sources

The Adaptive Biased Coin Design for Sequential Experiments [PDF]

Annals of Statistics, 1978
In comparing two treatments, eligible subjects come to the experiment sequentially and must be treated at once. To reduce experimental bias and to increase the precision of inference about treatment effects, the adaptive biased coin design, which offers a compromise between perfect balance and complete randomization, is proposed and analyzed.
L J Wei
exaly   +6 more sources

Selecting a Biased-Coin Design [PDF]

Statistical Science, 2014
Biased-coin designs are used in clinical trials to allocate treatments with some randomness while maintaining approximately equal allocation. More recent rules are compared with Efron's [Biometrika 58 (1971) 403-417] biased-coin rule and extended to allow balance over covariates.
A. Atkinson
semanticscholar   +6 more sources

Determination of the MEC90 of Oxycodone for Preventing Perioperative Shivering in Pregnant Patients Undergoing Caesarean Delivery with Neuraxial Anaesthesia: A Biased-Coin up-and-Down Sequential Allocation Trial [PDF]

Drug Design, Development and Therapy
Xinlei Lu,1,* Kaiyu Chen,1,2,* Ye Xuan,1,2 Mengting Shen,1,2 Weiping Lei,1 Yaqin Huang,1 Jianliang Sun1 1Department of Anaesthesiology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, People’s ...
Lu X, Chen K, Xuan Y, Shen M, Lei W, Huang Y, Sun J   +6 more
doaj   +6 more sources

Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial [PDF]

Drug Design, Development and Therapy
Fangsheng Xu,1,* Yuanyuan Cui,2,* Zhengle Wang,1 Rongguang Liu,1 Jian Tang,1 Yuan Xu,1 Luoyun Li,3 Chunyu Li,4 Meifang Wang,1 Jianfeng Pu1 1Department of Anesthesiology, Changshu No.
Xu F, Cui Y, Wang Z, Liu R, Tang J, Xu Y, Li L, Li C, Wang M, Pu J   +9 more
doaj   +3 more sources

Multi-objective optimal designs in comparative clinical trials with covariates: The reinforced doubly adaptive biased coin design [PDF]

The Annals of Statistics, 2012
The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the treatment allocations.
BALDI ANTOGNINI, ALESSANDRO, ZAGORAIOU, MAROUSSA   +1 more
semanticscholar   +8 more sources

Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery [PDF]

Drug Design, Development and Therapy
Xiaolin Tang,1,* Yu Liang,1,* Yuting Hu,1 Peng Li,1 Jiani Wang,1 Yujue Wang,2 Min Xie1 1Department of Anaesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China ...
Tang X, Liang Y, Hu Y, Li P, Wang J, Wang Y, Xie M   +6 more
doaj   +3 more sources

Optimal Programmed Intermittent Epidural Bolus Interval for Video-Assisted Thoracic Surgery Lobectomy: A Biased-Coin Up-Down Study of Ropivacaine-Sufentanil [PDF]

Drug Design, Development and Therapy
Chengfei Feng,1,* Jijin Wen,2,* Guozhong Lai,3,* Xiaofan Lu,2 Guanli Luo,2 Yali Lu,2 Wei Li,2 Renchun Lai2 1Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University ...
Feng C, Wen J, Lai G, Lu X, Luo G, Lu Y, Li W, Lai R   +7 more
doaj   +3 more sources

Maximum effective volume of 0.25% ropivacaine for preventing hemidiaphragmatic paralysis in 90% of patients undergoing shoulder arthroscopy: a biased coin up-and-down sequential allocation trial for ultrasound-guided superior trunk block [PDF]

BMC Anesthesiology
Background Compared to interscalene block (ISB), the superior trunk block (STB) lowers the incidence of hemidiaphragmatic paralysis (HDP) without compromising analgesic efficacy, making it a valuable alternative.
Kai Wang, Hongwei Zhu, Yangyang Zhou, Shukai Gui, Yonghua Li   +4 more
doaj   +3 more sources