Zur Kenntnis der Biguanide [PDF]
Journal für Praktische Chemie, 1911 n ...
Georg Cohn
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Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds. [PDF]
Pharmaceuticals (Basel)N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Zhigulin AS, Novikova AO, Barygin OI.
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Synthetic accesses to biguanide compounds [PDF]
Beilstein Journal of Organic Chemistry, 2021 Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy. This class of compounds has found broad applications such as reaction catalysts, organic strong bases, ligands for metal complexation, or versatile starting materials in organic ...
Grytsai, Oleksandr +2 more
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Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation [PDF]
Cell Reports, 2019 Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk ...
Atrih, Abdelmadjid +10 more
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Retrospective nationwide study on the trends in first‐line antidiabetic medication for patients with type?2 diabetes in Japan [PDF]
Journal of Diabetes Investigation, 2022 journal ...
Bouchi Ryotaro +8 more
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Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability [PDF]
Frontiers in Pharmacology, 2018 The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Adriana Bajetto +13 more
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway. [PDF]
Cell Rep MedThe biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients with breast cancer (BC ...
Park JH +25 more
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Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients. [PDF]
PLoS OneBackgroundWestern guidelines often recommend biguanides as the first-line treatment for diabetes. However, dipeptidyl peptidase-4 (DPP-4) inhibitors, alongside biguanides, are increasingly used as the first-line therapy for type 2 diabetes (T2DM) in ...
Nakatani E +14 more
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The uses of biguanides in diabetes mellitus [PDF]
Postgraduate Medical Journal, 1968 H. Keen, R. J. Jarrett
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Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) [PDF]
Contact Dermatitis, 2020 AbstractBackgroundPolyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad‐spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed ...
Cecilia Svedman +10 more
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