Results 1 to 10 of about 22,636 (317)
Frontiers in Medicine, 2022 ObjectiveDiabetes mellitus (DM) is associated with immune dysregulation, while sulfonylureas or biguanides have been linked to anti-inflammatory mechanisms.
Yu-Jih Su +7 more
doaj +2 more sources
Scientific Reports, 2021 To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold.
Takayuki Sakai +6 more
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Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase [PDF]
BMC Biology, 2016 BackgroundThe biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I.
H. R. Bridges +3 more
semanticscholar +3 more sources
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides [PDF]
Nature, 2014 As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues, cancer cells must adapt their metabolism to the tumour microenvironment.
Kıvanç Birsoy +9 more
semanticscholar +5 more sources
Cancer Medicine, 2020 Ovarian cancer is the most lethal gynecological malignancy. Currently, new chemotherapeutic strategies are required to improve patient outcome and survival.
Qiong Wang +8 more
doaj +2 more sources
Disorder of Glucose Metabolism and Therapy: Implications on the Natural History of Advanced Chronic Liver Disease [PDF]
GE: Portuguese Journal of GastroenterologyIntroduction: Hepatogenous diabetes (HD) is a disorder of glucose metabolism (DGM) that develops as a complication of advanced chronic liver disease (ACLD) with an estimated prevalence of 20–70%.
Sofia Garcês Soares +11 more
doaj +2 more sources
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation [PDF]
Cell Reports, 2019 Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk ...
Diana Vara-Ciruelos +9 more
doaj +5 more sources
Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds [PDF]
PharmaceuticalsN-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin +2 more
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Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
Cell Reports, 2019 Summary: Metabolic flexibility allows cells to adapt to various environments and limits the efficacy of metabolic drugs. Therapeutic targeting of cancer metabolism relies on defining limiting requirements and vulnerabilities in the highly dynamic ...
Hamidullah Khan +7 more
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Biguanides enhance antifungal activity against Candida glabrata
Virulence, 2018 Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge.
Shuying Xu +13 more
doaj +2 more sources