The uses of biguanides in diabetes mellitus [PDF]
Postgraduate Medical Journal, 1968 H. Keen, R. J. Jarrett
openalex +4 more sources
Journal of Clinical Endocrinology and Metabolism, 2020 CONTEXT Prostate cancer (PCa) is one of the leading causes of cancer-related death among male population worldwide. Unfortunately, current medical treatments fail to prevent PCa progression in a high percentage of cases; therefore, new therapeutic tools ...
J. Jiménez-Vacas +12 more
semanticscholar +1 more source
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]
, 2013 Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C +8 more
core +6 more sources
As biguanidas na terapêutica da diabetes.
Acta Médica Portuguesa, 1989 Biguanides are useful drugs in diabetes but their indications are very precise. The danger of lactic acidosis can be avoided with the use of metformin, the less toxic of biguanides, and strict respect for contraindications.
A M Saraiva
doaj +1 more source
Inhaled biguanides and mTOR inhibition for influenza and coronavirus (Review)
World Academy of Sciences Journal, 2020 The mammalian target of rapamycin (mTOR) signaling pathway senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis.
S. Lehrer
semanticscholar +1 more source
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]
, 2017 Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P +6 more
core +1 more source
Pharmacogenetics of Anti-Diabetes Drugs
Pharmaceuticals, 2010 A variety of treatment modalities exist for individuals with type 2 diabetes mellitus (T2D). In addition to dietary and physical activity interventions, T2D is also treated pharmacologically with nine major classes of approved drugs.
Johanna K. DiStefano +1 more
doaj +1 more source
The welfare impact of parallel imports: A structural approach applied to the German market for oral anti-diabetics [PDF]
, 2014 We investigate the welfare impact of parallel imports using a large panel data set containing monthly information on sales, ex-factory prices, and further product characteristics for all 700 anti-diabetic drugs sold in Germany between 2004 and 2010.
Duso, Tomaso +2 more
core +5 more sources
The effect of concomitant DPPIVi use on glycaemic control and hypoglycaemia with insulin glargine 300 U/mL (Gla-300) versus insulin glargine 100 U/mL (Gla-100) in people with type 2 diabetes: A patient-level meta-analysis of EDITION 2 and 3 [PDF]
, 2018 Aims To evaluate the effect of concomitant dipeptidyl peptidase IV inhibitor (DPPIVi) use on efficacy and safety of insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100) in people with type 2 diabetes on oral antihyperglycaemic drugs ...
Brito-Sanfiel, Miguel +7 more
core +4 more sources
Frontiers in Pharmacology, 2018 The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others.
Hector E. Sanchez-Ibarra +11 more
doaj +1 more source