Results 21 to 30 of about 15,321 (234)

Caracterização microbiológica e clínica de surtos de "red leg" em Minas Gerais e avaliação do efeito bactericida in vitro do Vantocil IB® para Aeromonas hydrophila Microbiological and clinical characterization of "red leg" outbreaks in Minas Gerais, Brazil, and evaluation of in vitro bacterial effects of Vantocil IB® for Aeromonas hydrophila

Ciência Rural, 2000
Com o objetivo da caracterização da ocorrência de "red leg" em Minas Gerais, avaliaram-se rãs jovens e adultas que apresentavam úlceras nas patas e dedos, derrame hemorrágico na pele da região ventral, incoordenação motora, altas taxas de mortalidade em ...
Anna Christina de Almeida, Luiz Eduardo Ristow, Tânia de Toledo Martins Buelta   +2 more
doaj   +1 more source

Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment

Scientific Reports, 2021
To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold.
Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa   +6 more
doaj   +1 more source

Metformin use in pregnancy: promises and uncertainties [PDF]

, 2017
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core   +1 more source

Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis

Molecules, 2019
As type 2 diabetes mellitus (T2DM) predisposes patients to endothelial cell injury and dysfunction, improvement of vascular function should be an important target for therapy.
Magdalena Markowicz-Piasecka, Kristiina M. Huttunen, Adrianna Sadkowska, Joanna Sikora   +3 more
doaj   +1 more source

A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology

Pharmaceutics, 2021
Aging is considered a contributing factor to many diseases such as cardiovascular disease, Alzheimer’s disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is one of the most common sensory impairments worldwide, affecting one in
Jacqueline Chester, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian, Hani Al-Salami   +10 more
doaj   +1 more source

Metformin in the treatment of breast cancer among patients with metabolic syndrome

Опухоли женской репродуктивной системы, 2015
Breast cancer (BC) is one of the most common cancer among women worldwide. In 2005, the International Diabetes Federation (International Diabetes Federation) declared metabolic syndrome is one of the main problems of modern medicine, as it increases the ...
R. V. Lyubota
doaj   +1 more source

Mono- and Dinuclear Aluminium Complexes Derived from Biguanide and Carbothiamide Ligands

Inorganics, 2021
Dianionic N,N-chelating ligands play a crucial role in coordination chemistry, but reports on related complexes remain limited to certain types of ligands.
Maximilian Dehmel, Helmar Görls, Robert Kretschmer   +2 more
doaj   +1 more source

Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42) [PDF]

, 2017
Little is known about the relationships between patient factors and the antihyperglycemic agents that have been prescribed as initial therapy by diabetes specialists for patients with type 2 diabetes.
Fujihara Kazuya, Igarashi Risa, Kawai Koichi, Maegawa Hiroshi, Matsubayashi Yasuhiro, Matsunaga Satoshi, Shimano Hitoshi, Sone Hirohito, Tanaka Shiro, Yamada Takaho, Yamazaki Katsuya, Yokoyama Hiroki, 島野 仁   +12 more
core   +1 more source

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

Cellular Physiology and Biochemistry, 2018
Background/Aims: Biguanides are anti-hyperglycaemic agents used to treat diabetes by acting primarily on the liver, inhibiting hepatic gluconeogenesis. However, biguanides may target other key metabolic tissues to exert beneficial actions. As the “master
Mari C. Vázquez-Borrego, Antonio C. Fuentes-Fayos, Manuel D. Gahete, Justo P. Castaño, Rhonda D. Kineman, Raúl M. Luque   +5 more
doaj   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources