Results 31 to 40 of about 22,636 (317)

Editorial:Metformin: Beyond Diabetes [PDF]

, 2019
International ...
Bost, Canto, El-Mir, Evans, Ferreira, Foretz, Foretz, Forslund, Hawley, Kaminski, Leung, Madiraju, Martin-Montalvo, Mohan, Neumann, Owen, Patel, Rena, Saxton, Zhou   +19 more
core   +3 more sources

Synthesis and Coordination Chemistry of 3,4-Ethylene-Bridged 1,1,2,5-Tetrasubstituted Biguanides.

Inorganic Chemistry, 2020
The synthesis of 3,4-ethylene-bridged 1,1,2,5-tetrasubstituted biguanides is reported, which are accessible by three alternative routes. Exemplary molecular structures of the ligand and an observed side product have been elucidated by X-ray diffraction ...
Maximilian Dehmel, V. Vass, Lukas Prock, H. Görls, R. Kretschmer   +4 more
semanticscholar   +1 more source

Metformin use in pregnancy: promises and uncertainties [PDF]

, 2017
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core   +1 more source

Does atorvastatin work more effectively than biguanides in reducing cardiovascular risk factors?

Journal of Pharmacy and Bioallied Sciences, 2011
Increased risk of coronary artery disease in diabetic persons is associated with increased level of lipoproteins. Usually, such risks are reverted with glycemic control by antidiabetic medicines in Type I diabetes millitus.
Afshan Siddiq, Rafeeq Alam Khan, Sadia Ghousia Baig   +2 more
doaj   +1 more source

A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology

Pharmaceutics, 2021
Aging is considered a contributing factor to many diseases such as cardiovascular disease, Alzheimer’s disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is one of the most common sensory impairments worldwide, affecting one in
Jacqueline Chester, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian, Hani Al-Salami   +10 more
doaj   +1 more source

Initial combination therapy for patients with type 2 diabetes mellitus: considerations for metformin plus linagliptin

Drugs in Context, 2013
For patients with type 2 diabetes mellitus, management of hyperglycemia is typically complex, and few patients successfully achieve and maintain recommended targets for glycated hemoglobin (HbA1c).
Jeffrey Freeman
doaj   +1 more source

Mono- and Dinuclear Aluminium Complexes Derived from Biguanide and Carbothiamide Ligands

Inorganics, 2021
Dianionic N,N-chelating ligands play a crucial role in coordination chemistry, but reports on related complexes remain limited to certain types of ligands.
Maximilian Dehmel, Helmar Görls, Robert Kretschmer   +2 more
doaj   +1 more source

Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness

JAMA psychiatry, 2019
Importance Drug repurposing is potentially cost-effective, low risk, and necessary in psychiatric drug development. The availability of large, routine data sets provides the opportunity to evaluate the potential for currently used medication to benefit ...
J. Hayes, A. Lundin, S. Wicks, G. Lewis, I. Wong, D. Osborn, C. Dalman   +6 more
semanticscholar   +1 more source

Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42) [PDF]

, 2017
Little is known about the relationships between patient factors and the antihyperglycemic agents that have been prescribed as initial therapy by diabetes specialists for patients with type 2 diabetes.
Fujihara Kazuya, Igarashi Risa, Kawai Koichi, Maegawa Hiroshi, Matsubayashi Yasuhiro, Matsunaga Satoshi, Shimano Hitoshi, Sone Hirohito, Tanaka Shiro, Yamada Takaho, Yamazaki Katsuya, Yokoyama Hiroki, 島野 仁   +12 more
core   +1 more source

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources