Results 31 to 40 of about 15,321 (234)
Frontiers in Pharmacology, 2018 The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others.
Hector E. Sanchez-Ibarra +11 more
doaj +1 more source
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]
, 2013 Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C +8 more
core +2 more sources
Does atorvastatin work more effectively than biguanides in reducing cardiovascular risk factors?
Journal of Pharmacy and Bioallied Sciences, 2011 Increased risk of coronary artery disease in diabetic persons is associated with increased level of lipoproteins. Usually, such risks are reverted with glycemic control by antidiabetic medicines in Type I diabetes millitus.
Afshan Siddiq +2 more
doaj +1 more source
Drugs in Context, 2013 For patients with type 2 diabetes mellitus, management of hyperglycemia is typically complex, and few patients successfully achieve and maintain recommended targets for glycated hemoglobin (HbA1c).
Jeffrey Freeman
doaj +1 more source
eLife, 2023 Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models.
Lucydalila Cedillo +18 more
doaj +1 more source
Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production [PDF]
, 2017 Metformin is widely prescribed as a first-choice antihyperglycemic drug for treatment of type 2 diabetes mellitus, and recent epidemiological studies showed its utility also in cancer therapy.
Alena Pecinova +8 more
core +2 more sources
Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders
Molecules, 2016 Natural products have always been exploited to promote health and served as a valuable source for the discovery of new drugs. In this review, the great potential of natural compounds and medicinal plants for the treatment or prevention of cardiovascular ...
Birgit Waltenberger +4 more
doaj +1 more source
Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides
SynOpen, 2021 This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi +3 more
doaj +1 more source
Risk of cardiovascular events from current, recent, and cumulative exposure to abacavir among persons living with HIV who were receiving antiretroviral therapy in the United States: a cohort study. [PDF]
, 2017 BackgroundThere is ongoing controversy regarding abacavir use in the treatment of HIV infection and the risk of subsequent development of cardiovascular disease.
Baxi, Sanjiv M +3 more
core +3 more sources