Results 51 to 60 of about 22,636 (317)
Journal of Conservative Dentistry, 2020 Background: Substantivity is one of the desirable characteristics of root canal irrigants. Among conventional endodontic irrigants, only chlorhexidine (CHX) is known to exert significant substantivity on root canal dentin.
Rita Chandki, V. Nikhil, S. Kalyan
semanticscholar +1 more source
The role of pharmacogenetics in the treatment of diabetes mellitus [PDF]
Journal of Medical Biochemistry, 2014 Diabetes mellitus is a heterogeneous group of disorders in which particular disease phenotypes can be characterized by a specific etiology and/or pathogenesis of the disease, but in many cases its classification is greatly impeded due to significant ...
Topić Elizabeta
doaj
Ciência Rural, 2000 Com o objetivo da caracterização da ocorrência de "red leg" em Minas Gerais, avaliaram-se rãs jovens e adultas que apresentavam úlceras nas patas e dedos, derrame hemorrágico na pele da região ventral, incoordenação motora, altas taxas de mortalidade em ...
Anna Christina de Almeida +2 more
doaj +1 more source
Biguanide iridium(III) complexes with potent antimicrobial activity [PDF]
, 2018 We have synthesized novel organoiridium(III) antimicrobial complexes containing a chelated biguanide, including the antidiabetic drug metformin. These 16- and 18-electron complexes were characterized by NMR, ESI-MS, elemental analysis, and X-ray ...
Chen, Feng +8 more
core +2 more sources
Molecules, 2019 As type 2 diabetes mellitus (T2DM) predisposes patients to endothelial cell injury and dysfunction, improvement of vascular function should be an important target for therapy.
Magdalena Markowicz-Piasecka +3 more
doaj +1 more source
Metformin in the treatment of breast cancer among patients with metabolic syndrome
Опухоли женской репродуктивной системы, 2015 Breast cancer (BC) is one of the most common cancer among women worldwide. In 2005, the International Diabetes Federation (International Diabetes Federation) declared metabolic syndrome is one of the main problems of modern medicine, as it increases the ...
R. V. Lyubota
doaj +1 more source
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin [PDF]
, 2018 Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue ...
Bush, Lauren N. +9 more
core +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Biguanides are anti-hyperglycaemic agents used to treat diabetes by acting primarily on the liver, inhibiting hepatic gluconeogenesis. However, biguanides may target other key metabolic tissues to exert beneficial actions. As the “master
Mari C. Vázquez-Borrego +5 more
doaj +1 more source
The risk of transmission of a viral haemorrhagic fever infection in a United Kingdom laboratory [PDF]
, 2017 No abstract ...
Shorten, Robert J., Wilson-Davies, Eleri
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Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status [PDF]
, 2014 Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4).
Baltazar, Fátima +5 more
core +2 more sources