Results 51 to 60 of about 15,321 (234)
Zur Kenntniss des Biguanids [PDF]
Berichte der deutschen chemischen Gesellschaft, 1892 n ...
Bamberger, E.-U.-G., Dieckmann, W.
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Frontiers in Endocrinology, 2018 Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabetic patients and is very well tolerated.
Emilie Jaune +3 more
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Role of Mitochondria in the Mechanism(s) of Action of Metformin
Frontiers in Endocrinology, 2019 Metformin is a drug from the biguanide family that is used for decades as the first-line therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide democratization, owing to its clinical efficacy, high safety profile and cheap cost ...
Guillaume Vial +3 more
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The thermodynamics of metabolism, cardiovascular performance and exercise, in health and diabetes: The objective of clinical markers [PDF]
, 2013 Extensive experience in UK National Health Service metabolic syndrome/type 2 diabetes clinics highlights the need for convenient clinical marker(s) which can be readily used to indicate the success or otherwise of alternative therapies.
Atherton, MA +4 more
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Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status [PDF]
, 2014 Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4).
Baltazar, Fátima +5 more
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Cancer Medicine, 2020 Ovarian cancer is the most lethal gynecological malignancy. Currently, new chemotherapeutic strategies are required to improve patient outcome and survival.
Qiong Wang +8 more
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BMC Medical Informatics and Decision Making, 2023 Background Biguanides and sulfonylurea are two classes of anti-diabetic medications that have commonly been prescribed all around the world. Diagnosis of biguanide and sulfonylurea exposures is based on history taking and physical examination; thus ...
Omid Mehrpour +6 more
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Management of type II Diabetes Mellitus [PDF]
, 2002 There is currently no cure for diabetes mellitus (DM). Irrespective of whether type I or type II diabetes is treated, the overall goals of management and therapy are targeted towards patient well being and may be summarised as follows.peer ...
Tonna, Antonella
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Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]
, 2015 Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C +7 more
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Reaction of Biguanides and Related Compounds. II. Reaction of Biguanides with Benzil
Chemical and Pharmaceutical Bulletin, 1972 Heating of 1-substituted biguanide with benzil in ethanol was found to give 2-substituted guanidilidene-5, 5-diphenylhydantoin, which was easily converted into 1, 1-diphenyl-1-substituted biguanidoacetic acid by hydrolysis with hydrochloric acid. The structureand the formation mechanism of 2-substituted guanidilidene-5, 5-diphenylhydantoin was also ...
Yoko Kojima +3 more
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