Results 91 to 100 of about 4,927,968 (256)

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

Journal of Lipid Research, 2004
Bile acid synthesis from cholesterol is tightly regulated via a feedback mechanism mediated by the farnesoid X receptor (FXR), a nuclear receptor activated by bile acids.
Tomoko Nishimaki-Mogami, Mizuho Une, Tomofumi Fujino, Yoji Sato, Norimasa Tamehiro, Yosuke Kawahara, Koichi Shudo, Kazuhide Inoue   +7 more
doaj   +1 more source

Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice [PDF]

, 2019
International audienceIt is well established that, besides facilitating lipid absorption, bile acids act as signaling molecules that modulate glucose and lipid metabolism.
Verkade, Henkjan J, Justina C. Wolters, Hoogerland, Joanne A., Haeusler, Rebecca A, Wolters, Justina C, Boer, Jan Freark, Gilles Mithieux, Niels L. Mulder, Henkjan J. Verkade, Wolters, Justina, Maaike H. Oosterveer, Fabienne Rajas, van Dijk, Theo H, Mulder, Niels L., Wolters, Justina C; id_orcid, Joanne A. Hoogerland, Theo H. van Dijk, Lei, Yu, Oosterveer, Maaike H, Bleeker, Aycha, Hoogerland, Joanne A, Kuipers, Folkert; id_orcid, Trijnie Bos, Verkade, Henkjan J., de Boer, Jan Freark, van Dijk, Theo H., Oosterveer, Maaike H., Haeusler, Rebecca, Mulder, Niels, Bloks, Vincent W, Kuivenhoven, Jan A, Aycha Bleeker, Dijk, Theo, Yu Lei, Verkade, Henkjan, Haeusler, Rebecca A., Jan A. Kuivenhoven, Kuivenhoven, Jan A., Bloks, Vincent, Rebecca A. Haeusler, Vincent W. Bloks, Mithieux, Gilles, Kuivenhoven, Jan, Mulder, Niels L, Folkert Kuipers, Wolters, Justina C., Hoogerland, Joanne, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike, Verkade, Henkjan J; id_orcid, Bos, Trijnie, Jan Freark de Boer, Bloks, Vincent W.   +53 more
core   +2 more sources

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Recent advances in understanding bile acid homeostasis [version 1; referees: 2 approved]

F1000Research, 2017
Bile acids are derived from cholesterol to facilitate intestinal nutrient absorption and biliary secretion of cholesterol. Recent studies have identified bile acids as signaling molecules that activate nuclear farnesoid X receptor (FXR) and membrane G ...
John YL Chiang
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Serum concentration of 7 alpha-hydroxycholesterol as an indicator of bile acid synthesis in humans.

Journal of Lipid Research, 1995
The serum concentration of 7 alpha-hydroxycholesterol as an indicator of total bile acid synthesis was investigated under different experimental conditions in humans. 7 alpha-Hydroxycholesterol was measured by gas-liquid chromatography-mass spectrometry,
C Hahn, C Reichel, K von Bergmann
doaj   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr −/− mice versus hamsters[S]

Journal of Lipid Research, 2013
Modulating bile acid synthesis has long been considered a good strategy by which to improve cholesterol homeostasis in humans. The farnesoid X receptor (FXR), the key regulator of bile acid synthesis, was, therefore, identified as an interesting target ...
Christophe Gardès, Evelyne Chaput, Andreas Staempfli, Denise Blum, Hans Richter, G. Martin Benson   +5 more
doaj   +1 more source

The effect of liver warm ischaemia reperfusion injury and modulation on bile composition evaluated by magnetic resonance spectroscopy [PDF]

, 2015
Orthotopic liver transplantation has become the preferred treatment for a variety of end-stage liver disease. As competency and survival rates increase, so does increasing demand, which puts greater strain on a static donor pool.
Hafez, T
core  

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source