Results 171 to 180 of about 4,927,968 (256)

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

The secretory protein, CLCF1, improves cholestatic liver disease by inhibiting hepatic bile acid synthesis and promoting bile acid excretion. [PDF]

Commun Biol
Liu M, Su Y, Hu Y, Shen M, Bao S, Gong Y, Ji Y, Wang L, Zhang Y, Wang X, Yang H, Chang Y, Zhou L.   +12 more
europepmc   +1 more source

A Transient Inflammatory Response Induced by Lipopolysaccharide Infusion Lowers Markers of Endogenous Cholesterol and Bile Acid Synthesis in Healthy Normocholesterolemic Young Men. [PDF]

Biomedicines, 2023
Mashnafi S, Baumgartner S, Mensink RP, Perlee D, van Vught LA, Lütjohann D, Plat J.   +6 more
europepmc   +1 more source

The synthesis of fluorinated bile acid analogues

, 2019
Bile acids are a type of acidic steroid found in the bile of mammals and other vertebrates. They are key in the digestion of food but also play a role as signalling molecules, regulating their own synthesis and transport, as well as being involved in the
Wynn, Rachel
core  

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source

The Diagnostic Saga of a Rare Congenital Bile Acid Synthesis Disorder: A Case Report. [PDF]

Clin Med Insights Pediatr
Yazbeck N, Hanna-Wakim R, Noun D, Karam PE.   +3 more
europepmc   +1 more source

The changes of hepatic bile acid synthesis and transport and bile acids profiles in isopsoralen-induced liver injury C57BL/6J mice. [PDF]

Pharm Biol, 2022
Men WJ, Meng ZJ, Wang Q, Chen MY, Zhai YX, Shi H, Wang AH, Zhou K.   +7 more
europepmc   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Treatment of Inborn Errors by Product Replacement: The Example of Inborn Errors of Bile Acid Synthesis. [PDF]

J Inherit Metab Dis
Clayton PT, Hirachan R, Murphy E.
europepmc   +1 more source

Redundant Functions of ERK1 and ERK2 Maintain Mouse Liver Homeostasis Through Down-Regulation of Bile Acid Synthesis. [PDF]

Hepatol Commun, 2022
Cingolani F, Liu Y, Shen Y, Wen J, Farris AB, Czaja MJ.   +5 more
europepmc   +1 more source