Results 141 to 150 of about 59,630 (258)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Cholesterol-Lowering Mechanism of Lactobacillus Bile Salt Hydrolase Through Regulation of Bifidobacterium pseudolongum in the Gut Microbiota. [PDF]

Nutrients
Liu Y, Kuang W, Li M, Wang Z, Liu Y, Zhao M, Huan H, Yang Y.   +7 more
europepmc   +1 more source

Taxonomic identification of bile salt hydrolase-encoding lactobacilli: Modulation of the enterohepatic bile acid profile. [PDF]

Imeta, 2023
Song Z, Feng S, Zhou X, Song Z, Li J, Li P.   +5 more
europepmc   +1 more source

A novel bile salt hydrolase-producing <i>Ligilactobacillus salivarius</i> prevents diet-induced obesity via regulation of bile acid metabolism and glucagon-like peptide 1 restoration. [PDF]

Gut Microbes
Lv J, Zhou L, Dai X, Landberg R, Meng H, Tian H, Zhang S, Liu T, Yin X, Zhang J, Song X, Bonny C, Blum S, Cao Y, Guo J, Peng W, Tan Y, Shi L.   +17 more
europepmc   +1 more source

Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Tirzepatide and SGLT2 inhibitors act through distinct but complementary mechanisms in obesity‐related HFpEF: tirzepatide targets adiposity, inflammation, and insulin resistance, while SGLT2 inhibitors improve decongestion, myocardial energetics, and cardiac remodeling.
Zakariye Isak Mohamed, Abdinasir Adam Shidane, Abdullahi Mohamud Abdiasis, Mohamed Hassan Hussein, Ayaanle Osman Ibrahim, Anas Ali Abdi, Kowthar Ismail Hashi, Mohamed Abdullahi Mohamud, Ali Jimale Mohamed   +8 more
wiley   +1 more source

Blautia coccoides Alleviates Acute Pancreatitis via Bile Salt Hydrolase-mediated Deoxycholic Acid Production and Farnesoid X Receptor Signaling. [PDF]

Cell Mol Gastroenterol Hepatol
Fu Y, Xu B, Qin W, Xiao W, Huang H, Hu J, Cui M, Mei Q, Fan J, Huang C, Zeng Y.   +10 more
europepmc   +1 more source

Self-Association of the Anion of 7-Oxodeoxycholic Acid (Bile Salt): How Secondary Micelles Are Formed. [PDF]

Int J Mol Sci, 2023
Poša M.
europepmc   +1 more source

Conjugated Linoleic Acid‐Enriched Fermented Dairy Modulates Microbiota and Metabolites to Alleviate MASLD: Insights From Multi‐Omics and Causal Mediation Analysis

Food Frontiers, Volume 7, Issue 5, September 2026.
In a 120‐day randomized trial, CLA‐enriched fermented dairy remodeled the gut microbiota and rewired host metabolic pathways in patients with MASLD. These changes were accompanied by reductions in ALT, total cholesterol, creatinine, and hs‐CRP, supporting a microbiota‐mediated dietary strategy for metabolic and liver health.
Fei Mi, Yanjiao Wang, Jia Xiong, Yiyuan Ma, Hongmei Pan, Jianzhong Yin, Yunmei Chai, Yao Wang, Xin Xu, Ai Zhang, Qingwen Ma, Hui Wang, Dongbai Liu, Shaoxiong Wu   +13 more
wiley   +1 more source

Bacteria enable tolerance to bile salt exposure in an immune-competent human intestinal model. [PDF]

Gut Microbes
Li Y, Wang CM, Zhao P, Fernez MT, Carrier RL.   +4 more
europepmc   +1 more source

Campylobacter jejuni benefits from the bile salt deoxycholate under low-oxygen condition in a PldA dependent manner. [PDF]

Gut Microbes, 2023
Cao X, van Putten JPM, Wösten MMSM.
europepmc   +1 more source