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Equine Veterinary Journal, Volume 58, Issue 3, Page 845-856, May 2026.Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn +6 more
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Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells
Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu +4 more
wiley +1 more source
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Nature, 1969
BILE salts are detergent-like molecules which occur widely in living systems. The dihydroxy and trihydroxy bile salts have an extraordinary ability to solubilize insoluble lipids such as phospholipids1–5, monoglycerides6 and long chain alkyl alcohols7.
D M, Small, W, Admirand
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BILE salts are detergent-like molecules which occur widely in living systems. The dihydroxy and trihydroxy bile salts have an extraordinary ability to solubilize insoluble lipids such as phospholipids1–5, monoglycerides6 and long chain alkyl alcohols7.
D M, Small, W, Admirand
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Bile Salt Metabolism:II. Bile Salts and Disease
Australian and New Zealand Journal of Medicine, 1977Alterations of bile salt metabolism have been shown in numerous diseases. Liver damage results in elevated serum bile salt concentrations which may be useful as a sensitive index of hepatocellular disease. Changes in the relative proportions of the individual bile salts in serum occur with cholestasis.
C B, Campbell, A E, Cowen
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Current Gastroenterology Reports, 2005
Alterations in bile acid metabolism and in the enterohepatic circulation are often associated with chronic diarrhea and should be considered when more common causes of chronic diarrhea have been excluded. Bile acid diarrhea most often occurs in disease or resection of the terminal ileum, in which there is increased exposure of the colonic mucosa to ...
Bruce W, Robb, Jeffrey B, Matthews
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Alterations in bile acid metabolism and in the enterohepatic circulation are often associated with chronic diarrhea and should be considered when more common causes of chronic diarrhea have been excluded. Bile acid diarrhea most often occurs in disease or resection of the terminal ileum, in which there is increased exposure of the colonic mucosa to ...
Bruce W, Robb, Jeffrey B, Matthews
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Annual Review of Physiology, 2002
▪ Abstract Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na+-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na+-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and ...
Meier, Peter J., Stieger, B.
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▪ Abstract Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na+-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na+-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and ...
Meier, Peter J., Stieger, B.
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Bile Salt Roles in Bile-Salt-Stimulated Lipase Activity
Journal of Pediatric Gastroenterology and Nutrition, 1986SummaryThe hydrolysis of 4‐nitrophenylacetate and phenylsalicylate, catalyzed by human milk lipase in the presence of a range of concentrations of sodium cholate, has been measured at pH 7.3 and 37.5°C, and maximum activity was observed for both substrates at 1 mmole/ dm−3 bile salt.
C J, O'Connor, P, Walde, R G, Wallace
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Bile Salt Metabolism:I. The Physiology of Bile Salts
Australian and New Zealand Journal of Medicine, 1977Bile salts are synthesized in the liver from cholesterol, conjugated with glycine or taurine and secreted in bile with cholesterol and lecithin. The molar concentrations of these three lipids determine solubility of cholesterol in bile. Within the gastrointestinal lumen bile salts play an essential role in lipid absorption and faty transport.
A E, Cowen, C B, Campbell
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2013
Bile salts play a crucial role in hepatobiliary and intestinal homeostasis and digestion. The liver synthesizes primary bile salts from cholesterol. Enzymatic modifications during their enterohepatic circulation lead to the formation of secondary and tertiary bile salts.
Maillette de Buy Wenniger, Lucas +2 more
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Bile salts play a crucial role in hepatobiliary and intestinal homeostasis and digestion. The liver synthesizes primary bile salts from cholesterol. Enzymatic modifications during their enterohepatic circulation lead to the formation of secondary and tertiary bile salts.
Maillette de Buy Wenniger, Lucas +2 more
openaire +2 more sources